Artigo

Human T-cell lymphotropic virus types I and II infections in a cohort of patients with neurological disorders in Belém, Pará, Brazil

Serum- and/or- cerebrospinal fluid (CSF) samples obtained from 190 patients suffering from chronic, progressive neurological disease were screened for the presence of human T-cell lymphotropic viruses type I (HTLV-I) and type II (HTLV-II) antibodies over a six-year period (1996 to 2001) in Belém, Pa...

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Autor principal: MACÊDO, Olinda
Outros Autores: LIMA, Telma Vitorina Ribeiro, GOMES, Maria de Lourdes Contente, LINHARES, Alexandre da Costa, LINHARES, Adriana de O., MOURA, Antônio de
Grau: Artigo
Idioma: eng
Publicado em: Universidade Federal do Pará 2018
Assuntos:
HTLV-I
HTLV-II
Doença neurológica
Infecção viral
Vírus linfotrópicos
CNPQ::CIENCIAS EXATAS E DA TERRA
Acesso em linha: http://repositorio.ufpa.br/jspui/handle/2011/10268
http://dx.doi.org/10.1590/S0036-46652004000100003
id ir-2011-10268
recordtype dspace
spelling ir-2011-102682018-10-02T05:26:11Z Human T-cell lymphotropic virus types I and II infections in a cohort of patients with neurological disorders in Belém, Pará, Brazil Infecção pelos vírus linfotrópicos humanos de células T tipos I e II entre pacientes com doença neurológica em Belém, Pará, Brasil MACÊDO, Olinda LIMA, Telma Vitorina Ribeiro GOMES, Maria de Lourdes Contente LINHARES, Alexandre da Costa LINHARES, Adriana de O. MOURA, Antônio de HTLV-I HTLV-II Doença neurológica Infecção viral Vírus linfotrópicos CNPQ::CIENCIAS EXATAS E DA TERRA Serum- and/or- cerebrospinal fluid (CSF) samples obtained from 190 patients suffering from chronic, progressive neurological disease were screened for the presence of human T-cell lymphotropic viruses type I (HTLV-I) and type II (HTLV-II) antibodies over a six-year period (1996 to 2001) in Belém, Pará, Brazil. Patients were of both sexes (male subjects, 52%) with ages ranging from 2 to 79 years (mean, 35.9). Overall, 15 (7.9%) subjects - of whom 12 (80%) were female adults - reacted HTLV-I/II-seropositive when screened by enzyme-linked immunosorbent assay (ELISA). Serum samples from 14 of these patients were also analyzed using a recombinant Western blot (WB) assay that yielded HTLV-I-, HTLV-II-, and HTLV-I/II- reactivities for 10 (71.4%), 3 (21.4%) and 1 (7.2%) of them, respectively. The yearly rates of HTLV-I/II antibodies ranged from 2.6% (2001) to 21.7% (2000), with progressively increasing seropositivities from 1998 to 2000. Altogether, walking difficulty (n = 5 subjects), spasticity (n = 4) and leg weakness (n = 3) accounted for 80% of symptoms recorded among the 15 patients whose sera had antibodies to HTLV-I/II as detected by ELISA. These findings provide evidence that both HTLV-I and HTLV-II play a role in the development of chronic myelopathy in Belém, Pará, Northern Brazil. Amostras de soro e/ou líquido céfalo-raquidiano (LCR) foram obtidas de 190 pacientes com quadro de doença neurológica crônica e progressiva, com vistas à detecção de anticorpos para os vírus linfotrópicos humanos de células T dos tipos I (HTLV-I) e II (HTLV-II), durante um período de seis anos (1996 a 2001) em Belém, Pará, Brasil. O grupo compreendia ambos os sexos (homens, 52%), com idades variando de 2 a 79 anos (média, 35,9 anos). Tomando-se os resultados como um todo, 15 (7,9%) indivíduos, incluindo 12 (80%) mulheres adultas, apresentaram anticorpos para HTLV-I/II a partir da triagem pelo procedimento imunoenzimático (ELISA). Soros de 14 desses pacientes também foram testados utilizando-se procedimento de Western blot (WB), alcançando-se freqüências de anticorpos para HTLV-I, HTLV-II e dupla reação (HTLV-I e HTLV-II) em 10 (71,4%), 3 (21,4%) e 1 (7,2%) indivíduos, respectivamente. As freqüências anuais de positividade para HTLV-I/II variaram de 2,6% (2001) a 21,7% (2000), em escala crescente no período de 1998 a 2000. Em conjunto, dificuldade na deambulação (n = 5 pacientes), espasticidade (n = 4) e hipotonia crural compreenderam 80% das manifestações clínicas registradas entre os 15 pacientes cujas amostras de soro continham anticorpos para HTLV-I/II, com base em ELISA. Tais resultados oferecem indicadores quanto a uma possível associação do HTLV-I e do HTLV-II à gênese das mielopatias crônicas em Belém, norte do Brasil. LIMA, T. V. L. R. Professor substituto na Universidade Federal do Pará, período 2002 - 2004 2018-10-01T20:42:17Z 2018-10-01T20:42:17Z 2004-02 Artigo de Periódico MACEDO, Olinda et al. Human T-cell lymphotropic virus types I and II infections in a cohort of patients with neurological disorders in Belém, Pará, Brazil. Revista do Instituto de Medicina Tropical de São Paulo, São Paulo, v. 46, n. 1, p. 13-17, jan./fev. 2004. Disponível em: <http://repositorio.ufpa.br/jspui/handle/2011/10268>. Acesso em:. 1678-9946 http://repositorio.ufpa.br/jspui/handle/2011/10268 http://dx.doi.org/10.1590/S0036-46652004000100003 eng Revista do Instituto de Medicina Tropical de São Paulo Acesso Aberto application/pdf Universidade Federal do Pará Brasil UFPA http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652004000100003&lng=pt&nrm=iso
institution Repositório Institucional - Universidade Federal do Pará
collection RI-UFPA
language eng
topic HTLV-I
HTLV-II
Doença neurológica
Infecção viral
Vírus linfotrópicos
CNPQ::CIENCIAS EXATAS E DA TERRA
spellingShingle HTLV-I
HTLV-II
Doença neurológica
Infecção viral
Vírus linfotrópicos
CNPQ::CIENCIAS EXATAS E DA TERRA
MACÊDO, Olinda
Human T-cell lymphotropic virus types I and II infections in a cohort of patients with neurological disorders in Belém, Pará, Brazil
topic_facet HTLV-I
HTLV-II
Doença neurológica
Infecção viral
Vírus linfotrópicos
CNPQ::CIENCIAS EXATAS E DA TERRA
description Serum- and/or- cerebrospinal fluid (CSF) samples obtained from 190 patients suffering from chronic, progressive neurological disease were screened for the presence of human T-cell lymphotropic viruses type I (HTLV-I) and type II (HTLV-II) antibodies over a six-year period (1996 to 2001) in Belém, Pará, Brazil. Patients were of both sexes (male subjects, 52%) with ages ranging from 2 to 79 years (mean, 35.9). Overall, 15 (7.9%) subjects - of whom 12 (80%) were female adults - reacted HTLV-I/II-seropositive when screened by enzyme-linked immunosorbent assay (ELISA). Serum samples from 14 of these patients were also analyzed using a recombinant Western blot (WB) assay that yielded HTLV-I-, HTLV-II-, and HTLV-I/II- reactivities for 10 (71.4%), 3 (21.4%) and 1 (7.2%) of them, respectively. The yearly rates of HTLV-I/II antibodies ranged from 2.6% (2001) to 21.7% (2000), with progressively increasing seropositivities from 1998 to 2000. Altogether, walking difficulty (n = 5 subjects), spasticity (n = 4) and leg weakness (n = 3) accounted for 80% of symptoms recorded among the 15 patients whose sera had antibodies to HTLV-I/II as detected by ELISA. These findings provide evidence that both HTLV-I and HTLV-II play a role in the development of chronic myelopathy in Belém, Pará, Northern Brazil.
format Artigo
author MACÊDO, Olinda
author2 LIMA, Telma Vitorina Ribeiro
GOMES, Maria de Lourdes Contente
LINHARES, Alexandre da Costa
LINHARES, Adriana de O.
MOURA, Antônio de
author2Str LIMA, Telma Vitorina Ribeiro
GOMES, Maria de Lourdes Contente
LINHARES, Alexandre da Costa
LINHARES, Adriana de O.
MOURA, Antônio de
title Human T-cell lymphotropic virus types I and II infections in a cohort of patients with neurological disorders in Belém, Pará, Brazil
title_short Human T-cell lymphotropic virus types I and II infections in a cohort of patients with neurological disorders in Belém, Pará, Brazil
title_full Human T-cell lymphotropic virus types I and II infections in a cohort of patients with neurological disorders in Belém, Pará, Brazil
title_fullStr Human T-cell lymphotropic virus types I and II infections in a cohort of patients with neurological disorders in Belém, Pará, Brazil
title_full_unstemmed Human T-cell lymphotropic virus types I and II infections in a cohort of patients with neurological disorders in Belém, Pará, Brazil
title_sort human t-cell lymphotropic virus types i and ii infections in a cohort of patients with neurological disorders in belém, pará, brazil
publisher Universidade Federal do Pará
publishDate 2018
url http://repositorio.ufpa.br/jspui/handle/2011/10268
http://dx.doi.org/10.1590/S0036-46652004000100003
_version_ 1832602157391544320
score 11.755432

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