Sepsis is an organ dysfunction caused by a dysregulated immune response to an
infection, the initial therapeutic approach to sepsis are broad spectrum antimicrobials,
which is not sufficient for control of infection, requiring association with other therapies
focused in the interruption of the inflammatory response chain, provided by the
pathogens. In this way, the Aedes Aegypti’s saliva presents immunomodulary features,
with a potential pro inflammatory cytokine inhibition, as well as the presence of nitric
oxide peptides activators. Therefore, it would be a great interest to search the saliva’s
immunomodulator effect in animal model sepses. In this regards, mices were pre
treated with Aedes aegypti saliva, and sepsis was induced by the cecal ligation and
puncture. After 12 and 24 hours, the samples were collected, and evaluated the
survival rate, bacteria level, leukocyte migration, and oxidative parameters (NO, EROs,
MDA e TEAC). The saliva improved the animal prognostic, increasing the survival rate
and weight. Furthermore, decreased the bacterial levels and increased the influx of
monocytes. The saliva, in addition, presented antioxidant effects by reducing
production of the reatives species, and increasing the antioxidant capacity, other than
decrease the lipid peroxidation. Thus, the saliva was capable to inhibit damages
caused by sepsis in animals in vivo, improving its prognostic.
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