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Artigo
Effects of hypertonic saline solution associated to remote ischemic perconditioning in kidney ischemia/reperfusion injury in rats
To evaluate the effects of hypertonic saline solution associated to remote ischemic perconditioning in renal ischemia/reperfusion injury in rats. Methods: Twenty five male rats (Wistar) underwent right nephrectomy and were distributed into five groups: Sham group (S); Ischemia/Reperfusion group (I/R...
Autor principal: | BRITO, Marcus Vinicius Henriques |
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Outros Autores: | YASOJIMA, Edson Yuzur, PÉRCARIO, Sandro, RIBEIRO JUNIOR, Rubens Fernando Gonçalves, CAVALCANTE, Lainy Carollyne da Costa, MONTEIRO, Andrew Moraes, COUTEIRO, Rodrigo Paracampo, RODRIGUES, Ivone Aline da Silva, SANTOS, Hellen Aparecida Geyer dos |
Grau: | Artigo |
Idioma: | eng |
Publicado em: |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
2019
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Acesso em linha: |
http://repositorio.ufpa.br/jspui/handle/2011/10808 http://dx.doi.org/10.1590/s0102-865020170030000005 |
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ir-2011-108082020-01-27T17:00:23Z Effects of hypertonic saline solution associated to remote ischemic perconditioning in kidney ischemia/reperfusion injury in rats BRITO, Marcus Vinicius Henriques YASOJIMA, Edson Yuzur PÉRCARIO, Sandro RIBEIRO JUNIOR, Rubens Fernando Gonçalves CAVALCANTE, Lainy Carollyne da Costa MONTEIRO, Andrew Moraes COUTEIRO, Rodrigo Paracampo RODRIGUES, Ivone Aline da Silva SANTOS, Hellen Aparecida Geyer dos Ischemia Reperfusion Saline solution Hypertonic Kidney Rats To evaluate the effects of hypertonic saline solution associated to remote ischemic perconditioning in renal ischemia/reperfusion injury in rats. Methods: Twenty five male rats (Wistar) underwent right nephrectomy and were distributed into five groups: Sham group (S); Ischemia/Reperfusion group (I/R) with 30 minutes of renal ischemia; Remote ischemic perconditioning group (Per) with three cycles of 10 minutes of I/R performed during kidney ischemia; Hypertonic saline solution group (HSS) treated with hypertonic saline solution (4ml/kg); remote ischemic perconditioning + Hypertonic saline solution group (Per+HSS) with both treatments. After reperfusion, blood samples were collected for BUN and creatinine serum levels analyzes. TBARS were evaluated in plasma and renal tissue to assess oxidative stress. Kidney histopathological examination were performed. Results: Per+HSS group showed a lower degree of renal dysfunction in relation to I/R group, whereas the technique of remote ischemic perconditioning isolated or associated with saline solution significantly reduced oxidative stress and histological damage. Conclusion:Remote ischemic perconditioning associated or not to saline solution promoted reduction of acute renal injury induced by ischemia/reperfusion. PERCÁRIO, S. Universidade Federal do Pará 2019-03-28T22:20:53Z 2019-03-28T22:20:53Z 2017-03 Artigo de Periódico BRITO, Marcus Vinicius Henriques et al. Effects of hypertonic saline solution associated to remote ischemic perconditioning in kidney ischemia/reperfusion injury in rats. Acta Cirúrgica Brasileira, São Paulo, v. 32, n. 3, p. 211-218, Mar. 2017. DOI: http://dx.doi.org/10.1590/s0102-865020170030000005. Disponível em: http://repositorio.ufpa.br/jspui/handle/2011/10808. Acesso em:. 1678-2674 http://repositorio.ufpa.br/jspui/handle/2011/10808 http://dx.doi.org/10.1590/s0102-865020170030000005 eng Acta Cirúrgica Brasileira Acesso Aberto application/pdf Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia Brasil SOBRADPEC http://ref.scielo.org/h7w9mc |
institution |
Repositório Institucional - Universidade Federal do Pará |
collection |
RI-UFPA |
language |
eng |
topic |
Ischemia Reperfusion Saline solution Hypertonic Kidney Rats |
spellingShingle |
Ischemia Reperfusion Saline solution Hypertonic Kidney Rats BRITO, Marcus Vinicius Henriques Effects of hypertonic saline solution associated to remote ischemic perconditioning in kidney ischemia/reperfusion injury in rats |
topic_facet |
Ischemia Reperfusion Saline solution Hypertonic Kidney Rats |
description |
To evaluate the effects of hypertonic saline solution associated to remote ischemic perconditioning in renal ischemia/reperfusion injury in rats. Methods: Twenty five male rats (Wistar) underwent right nephrectomy and were distributed into five groups: Sham group (S); Ischemia/Reperfusion group (I/R) with 30 minutes of renal ischemia; Remote ischemic perconditioning group (Per) with three cycles of 10 minutes of I/R performed during kidney ischemia; Hypertonic saline solution group (HSS) treated with hypertonic saline solution (4ml/kg); remote ischemic perconditioning + Hypertonic saline solution group (Per+HSS) with both treatments. After reperfusion, blood samples were collected for BUN and creatinine serum levels analyzes. TBARS were evaluated in plasma and renal tissue to assess oxidative stress. Kidney histopathological examination were performed. Results: Per+HSS group showed a lower degree of renal dysfunction in relation to I/R group, whereas the technique of remote ischemic perconditioning isolated or associated with saline solution significantly reduced oxidative stress and histological damage. Conclusion:Remote ischemic perconditioning associated or not to saline solution promoted reduction of acute renal injury induced by ischemia/reperfusion. |
format |
Artigo |
author |
BRITO, Marcus Vinicius Henriques |
author2 |
YASOJIMA, Edson Yuzur PÉRCARIO, Sandro RIBEIRO JUNIOR, Rubens Fernando Gonçalves CAVALCANTE, Lainy Carollyne da Costa MONTEIRO, Andrew Moraes COUTEIRO, Rodrigo Paracampo RODRIGUES, Ivone Aline da Silva SANTOS, Hellen Aparecida Geyer dos |
author2Str |
YASOJIMA, Edson Yuzur PÉRCARIO, Sandro RIBEIRO JUNIOR, Rubens Fernando Gonçalves CAVALCANTE, Lainy Carollyne da Costa MONTEIRO, Andrew Moraes COUTEIRO, Rodrigo Paracampo RODRIGUES, Ivone Aline da Silva SANTOS, Hellen Aparecida Geyer dos |
title |
Effects of hypertonic saline solution associated to remote ischemic perconditioning in kidney ischemia/reperfusion injury in rats |
title_short |
Effects of hypertonic saline solution associated to remote ischemic perconditioning in kidney ischemia/reperfusion injury in rats |
title_full |
Effects of hypertonic saline solution associated to remote ischemic perconditioning in kidney ischemia/reperfusion injury in rats |
title_fullStr |
Effects of hypertonic saline solution associated to remote ischemic perconditioning in kidney ischemia/reperfusion injury in rats |
title_full_unstemmed |
Effects of hypertonic saline solution associated to remote ischemic perconditioning in kidney ischemia/reperfusion injury in rats |
title_sort |
effects of hypertonic saline solution associated to remote ischemic perconditioning in kidney ischemia/reperfusion injury in rats |
publisher |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
publishDate |
2019 |
url |
http://repositorio.ufpa.br/jspui/handle/2011/10808 http://dx.doi.org/10.1590/s0102-865020170030000005 |
_version_ |
1787147746470264832 |
score |
11.674752 |