Analysis of imatinib adherence in chronic myeloid leukemia: a retrospective study in a referral hospital in the brazilian amazon
Background: There has been a revolution in the treatment of Chronic Myeloid Leukemia since imatinib's introduction. However, patient adherence has a great impact on the response obtained with medical treatment. This study's objective was to analyze the drug adherence and the factors that influenced...
| Autor principal: | ANDRADE, Alan Rodrigues |
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| Outros Autores: | PAZ, Igor Penha, EVANGELISTA, Talitta Ribeiro, MELLO, Vanessa Joia de, HAMOY, Moisés, LEITÃO, Daniel da Silva |
| Grau: | Artigo |
| Idioma: | eng |
| Publicado em: |
Associação Brasileira de Hematologia, Hemoterapia e Terapia Celular
2019
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| Acesso em linha: |
http://repositorio.ufpa.br/jspui/handle/2011/11396 http://dx.doi.org/10.1016/j.htct.2018.09.006 |
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ir-2011-11396 |
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ir-2011-113962019-12-17T15:36:27Z Analysis of imatinib adherence in chronic myeloid leukemia: a retrospective study in a referral hospital in the brazilian amazon Análise da adesão ao imatinibe na leucemia mielóide crônica: estudo retrospectivo em hospital de referência na amazônia brasileira ANDRADE, Alan Rodrigues PAZ, Igor Penha EVANGELISTA, Talitta Ribeiro MELLO, Vanessa Joia de HAMOY, Moisés LEITÃO, Daniel da Silva Leucemia Mielóide Crônica Adesão Imatinib Amazon Leukemia Myelogenous Chronic Adherence Background: There has been a revolution in the treatment of Chronic Myeloid Leukemia since imatinib's introduction. However, patient adherence has a great impact on the response obtained with medical treatment. This study's objective was to analyze the drug adherence and the factors that influenced it in patients with Chronic Myeloid Leukemia in a referral hospital in the Brazilian Amazon. Method: This was a retrospective study including 120 patients with Chronic Myeloid Leukemia from January 2002 to December 2014. The adherence was estimated by the Proportion of Days Covered and the persistence by Kaplan-Meier analysis. The data was analyzed in Epi Info 7® software and the relationship between the variables was analyzed by Fisher's exact test. A p-value lower than 0.05 was considered significant. Results: Twenty-seven patients (22.5%) were considered non-adherent. There has been irregular medication use and disinterest in the treatment in 20.83% (n = 25), of which 13 were considered non-adherent (p < 0.001). A total of 26.67% (n = 32) abandoned the treatment for a period. Of those, 56.25% (n = 18) were non-adherent (p < 0.001). Distance to the hospital, lack of medication and side-effects were all non-significant to low adherence. At the end of a 360-day follow-up, 44.16% (n = 53) of patients presented a break in persistence, whose average was 255 days. Conclusion: The adherence found in this study was similar to that found in others of its kind. The only factors that negatively influenced the adherence were disinterest and abandonment of treatment, which can reflect the need to individually educate Chronic Myeloid Leukemia patients. Fundo: Houve uma revolução no tratamento da Leucemia Mielóide Crônica desde a introdução do imatinibe. No entanto, a adesão do paciente tem um grande impacto na resposta obtida com o tratamento médico. O objetivo deste estudo foi analisar a adesão medicamentosa e os fatores que a influenciaram em pacientes com Leucemia Mielóide Crônica em um hospital de referência na Amazônia brasileira. Método: Este foi um estudo retrospectivo incluindo 120 pacientes com Leucemia Mielóide Crônica, de janeiro de 2002 a dezembro de 2014. A adesão foi estimada pela Proporção de Dias Cobertos e a persistência pela análise de Kaplan-Meier. Os dados foram analisados no software Epi Info 7 ® e a relação entre as variáveis foi analisada pelo teste exato de Fisher. Um valor p menor que 0,05 foi considerado significativo. Resultados: Vinte e sete pacientes (22,5%) foram considerados não aderentes. Houve uso irregular de medicamentos e desinteresse pelo tratamento em 20,83% ( n = 25), dos quais 13 foram considerados não aderentes ( p<0,001). Um total de 26,67% ( n = 32) abandonou o tratamento por um período. Destes, 56,25% ( n = 18) eram não aderentes ( p <0,001). Distância para o hospital, falta de medicação e efeitos colaterais foram todos não significativos para baixa adesão. Ao final de um seguimento de 360 dias, 44,16% ( n = 53) dos pacientes apresentaram quebra de persistência, cuja média foi de 255 dias. Conclusão: A adesão encontrada neste estudo foi semelhante à encontrada em outras do gênero. Os únicos fatores que influenciaram negativamente a adesão foram o desinteresse e o abandono do tratamento, o que pode refletir a necessidade de educar individualmente os pacientes com Leucemia Mielóide Crônica. UFPA - Universidade Federal do Pará 2019-08-06T12:14:25Z 2019-08-06T12:14:25Z 2019-06 Artigo de Periódico ANDRADE, Alan Rodrigues et al. Analysis of imatinib adherence in chronic myeloid leukemia: a retrospective study in a referral hospital in the brazilian amazon. Hematology, Transfusion and cell Therapy, São Paulo, v. 41, n. 2, p. 106-113, abr./jun. 2019. DOI: http://dx.doi.org/10.1016/j.htct.2018.09.006. Disponível em: http://repositorio.ufpa.br/jspui/handle/2011/11396. Acesso em:. 2531-1387 http://repositorio.ufpa.br/jspui/handle/2011/11396 http://dx.doi.org/10.1016/j.htct.2018.09.006 eng Hematology, Transfusion and Cell Therapy Acesso Aberto application/pdf Associação Brasileira de Hematologia, Hemoterapia e Terapia Celular Brasil ABHH http://ref.scielo.org/bm2j4z |
| institution |
Repositório Institucional - Universidade Federal do Pará |
| collection |
RI-UFPA |
| language |
eng |
| topic |
Leucemia Mielóide Crônica Adesão Imatinib Amazon Leukemia Myelogenous Chronic Adherence |
| spellingShingle |
Leucemia Mielóide Crônica Adesão Imatinib Amazon Leukemia Myelogenous Chronic Adherence ANDRADE, Alan Rodrigues Analysis of imatinib adherence in chronic myeloid leukemia: a retrospective study in a referral hospital in the brazilian amazon |
| topic_facet |
Leucemia Mielóide Crônica Adesão Imatinib Amazon Leukemia Myelogenous Chronic Adherence |
| description |
Background:
There has been a revolution in the treatment of Chronic Myeloid Leukemia since imatinib's introduction. However, patient adherence has a great impact on the response obtained with medical treatment. This study's objective was to analyze the drug adherence and the factors that influenced it in patients with Chronic Myeloid Leukemia in a referral hospital in the Brazilian Amazon.
Method:
This was a retrospective study including 120 patients with Chronic Myeloid Leukemia from January 2002 to December 2014. The adherence was estimated by the Proportion of Days Covered and the persistence by Kaplan-Meier analysis. The data was analyzed in Epi Info 7® software and the relationship between the variables was analyzed by Fisher's exact test. A p-value lower than 0.05 was considered significant.
Results:
Twenty-seven patients (22.5%) were considered non-adherent. There has been irregular medication use and disinterest in the treatment in 20.83% (n = 25), of which 13 were considered non-adherent (p < 0.001). A total of 26.67% (n = 32) abandoned the treatment for a period. Of those, 56.25% (n = 18) were non-adherent (p < 0.001). Distance to the hospital, lack of medication and side-effects were all non-significant to low adherence. At the end of a 360-day follow-up, 44.16% (n = 53) of patients presented a break in persistence, whose average was 255 days.
Conclusion:
The adherence found in this study was similar to that found in others of its kind. The only factors that negatively influenced the adherence were disinterest and abandonment of treatment, which can reflect the need to individually educate Chronic Myeloid Leukemia patients. |
| format |
Artigo |
| author |
ANDRADE, Alan Rodrigues |
| author2 |
PAZ, Igor Penha EVANGELISTA, Talitta Ribeiro MELLO, Vanessa Joia de HAMOY, Moisés LEITÃO, Daniel da Silva |
| author2Str |
PAZ, Igor Penha EVANGELISTA, Talitta Ribeiro MELLO, Vanessa Joia de HAMOY, Moisés LEITÃO, Daniel da Silva |
| title |
Analysis of imatinib adherence in chronic myeloid leukemia: a retrospective study in a referral hospital in the brazilian amazon |
| title_short |
Analysis of imatinib adherence in chronic myeloid leukemia: a retrospective study in a referral hospital in the brazilian amazon |
| title_full |
Analysis of imatinib adherence in chronic myeloid leukemia: a retrospective study in a referral hospital in the brazilian amazon |
| title_fullStr |
Analysis of imatinib adherence in chronic myeloid leukemia: a retrospective study in a referral hospital in the brazilian amazon |
| title_full_unstemmed |
Analysis of imatinib adherence in chronic myeloid leukemia: a retrospective study in a referral hospital in the brazilian amazon |
| title_sort |
analysis of imatinib adherence in chronic myeloid leukemia: a retrospective study in a referral hospital in the brazilian amazon |
| publisher |
Associação Brasileira de Hematologia, Hemoterapia e Terapia Celular |
| publishDate |
2019 |
| url |
http://repositorio.ufpa.br/jspui/handle/2011/11396 http://dx.doi.org/10.1016/j.htct.2018.09.006 |
| _version_ |
1787148986190135296 |
| score |
11.653393 |