Diabetes mellitus has been considered a 21st century epidemic and each year the number of
people with the disease increases worldwide. It is a disease caused by modifiable factors such
as hypercaloric diet, sedentary lifestyle, and non-modifiable factors such as genetic heritability.
The objective of this study was to describe the occurrence of genetic markers associated with
type 2 diabetes mellitus in the population of the city of Belém do Pará, Brazil. The specific
objectives were: to validate the association between type 2 diabetes mellitus and the genes:
KCNJ11 rs5219, TCF7L2 rs7901695, PPARγ rs1801282, ABCA1 rs9282541, FTO rs8050136
and rs9939609; and investigate the association between factors related to the development and
evolution of type 2 diabetes mellitus such as: BMI, waist circumference, systemic arterial
hypertension, sedentary lifestyle, smoking, alcoholism and metabolic syndrome. A research
form was applied and blood was collected for DNA extraction. A case-control study was
conducted with 147 individuals. The sample consisted of 54 women and 49 men, totaling 103
individuals with the disease, and the control group with 27 women and 17 men without type 2
diabetes mellitus, pre-diabetes or any other type of diabetes, totaling 44 individuals. The study
was carried out at the Belém Municipal Institute of Welfare and Care. Regarding the genes
studied, only KCNJ11 rs5219 was statistically significant in women (n = 81, p = 0.025).
Considering the factors associated with type 2 diabetes mellitus, only the metabolic syndrome
presented statistical significance in both genders (p = 0.01).
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