Human Papilloma Virus (HPV) has an oncogenic potential capable of inducing the development
of cancers: anal, penile, vulvar, oropharyngeal and cervical, making it a major worldwide public
health problem. The production of the quadrivalent vaccine has been the most effective and
most cost-effective method for controlling the virus, made available by the Unified Health
System (SUS) for girls and boys. The State of Pará had one of the lowest rates of vaccination
coverage against HPV since its insertion in the vaccination calendar. Therefore, the objective
of this research was to analyze the knowledge of parents and guardians about HPV and its
vaccine, as well as to identify the factors associated with the barrier and acceptability of the
vaccine. This is a cross-sectional study, with a quantitative approach, carried out with 247
parents and guardians in peripheral areas covered by the Terra Firme Family Health Strategy in
the city of Belém - PA. The results showed that in the studied population, the age between 28
to 37 years, stable union and illiterate education, fundamental and medium, are factors
associated with low and medium knowledge about HPV and its vaccine. It is concluded that
although the degree of knowledge of parents and guardians is medium to high and that their
acceptability of the vaccine is high, this has little repercussion for a result recommended by
WHO for the vaccination coverage of children / adolescents. Therefore, it is necessary to
evaluate and select the most effective HPV promotion and prevention strategies.
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