Introduction: Entrepreneurship can provide nurses with a range of possibilities for professional insertion focused on innovation, creation of opportunities and promotion of new actions, so it is necessary that this practice is stimulated. The objective of this work is to develop a prototype of educational technology (TE) for business development of nurses. Method: This is a methodological research divided into two stages. The first stage was the construction of an Integrative Literature Review (RIL), which aimed to identify through the collection of scientific evidence the initiatives of the development of entrepreneurial education; the second methodological stage corresponds to the construction of TE. The sample consisted of nurses from different regions of Brazil identified in the macro project: “Business entrepreneur nurses in Brazil: labor market and training”. After checking the inclusion and exclusion criteria, the participants were contacted and a quantitative of 11 entrepreneurial nurses was obtained. Data collection took place with two groups of entrepreneurial nurses in October 2022 on the Google Meet platform, through Verbalization and Observation Groups, where it was carried out: reality observation; theorization and hypotheses of reality proposed by the methodology of problematization of the Arc de Maguerez. Data analysis was based on the inductive thematic analysis of Braun and Clarke. Results: The RIL is presented in the form of an article submitted in the Brazilian Journal of Medical Education. In the second methodological stage, four themes emerged: characteristics of the entrepreneur; opening of the business; contents of interest; and resources used to undertake. Based on the findings in the literature and the observation of reality, a Prototype of a New Business Program in Nursing was created: InovaEnf. The prototype was developed based on the four themes arising from the meetings, being divided into six stages: Entry and Contract; Training and Modeling; Planning; Execution; Feedback - Presentation of Solutions and Advice; Monitoring. Final considerations: Note the importance of encouraging entrepreneurship in the profession, providing the strengthening of professional autonomy and the conquest of new spaces, using innovation to generate products, services and/ or technology with the potential to promote positive changes in the context that the nurse is inserted.
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