Quinine levels in patients with uncomplicated falciparum malaria in the Amazon region of Brazil
We examined the plasmatic concentrations of quinine in patients with uncomplicated falciparum malaria in an endemic area of the Amazon region in Brazil in a prospective clinical trial, in which a standard three-day course of oral quinine plus doxycycline was used. We measured the quinine in the plas...
| Autor principal: | VIEIRA, José Luiz Fernandes |
|---|---|
| Outros Autores: | BORGES, Larissa Maria Guimarães, NASCIMENTO, Margareth Tavares Silva, GOMES, Andreza de Lourdes Souza |
| Grau: | Artigo |
| Idioma: | eng |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: |
http://www.repositorio.ufpa.br:8080/jspui/handle/2011/2428 |
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ir-2011-2428 |
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dspace |
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ir-2011-24282019-05-23T13:25:56Z Quinine levels in patients with uncomplicated falciparum malaria in the Amazon region of Brazil VIEIRA, José Luiz Fernandes BORGES, Larissa Maria Guimarães NASCIMENTO, Margareth Tavares Silva GOMES, Andreza de Lourdes Souza Amazônia brasileira Tratamento Malária falciparum Quinina We examined the plasmatic concentrations of quinine in patients with uncomplicated falciparum malaria in an endemic area of the Amazon region in Brazil in a prospective clinical trial, in which a standard three-day course of oral quinine plus doxycycline was used. We measured the quinine in the plasma samples on days 0 and 3by high performance liquid chromatography. The mean concentration of quinine was 6.04 ±2.21 µg/mL in male patients and 5.98 ±1.95 µg/mL in female patients. No significant differences in quinine concentration were observed between these two groups. All samples collected before starting treatment were negative for quinine. This information could help in the development of strategies for the rational use of antimalarial drugs in Brazil. 2011-12-16T13:54:18Z 2011-12-16T13:54:18Z 2008-10 Artigo de Periódico VIEIRA, José Luiz Fernandes et al. Quinine levels in patients with uncomplicated falciparum malaria in the Amazon region of Brazil. Brazilian Journal of Infectious Diseases, Salvador, v. 12, n. 5, p. 353-354, out. 2008. Disponível em: <http://www.scielo.br/pdf/bjid/v12n5/01.pdf>. Acesso em: 16 dez. 2011. http://dx.doi.org/10.1590/S1413-86702008000500001. 1413-8670 http://www.repositorio.ufpa.br:8080/jspui/handle/2011/2428 eng Acesso Aberto application/pdf |
| institution |
Repositório Institucional - Universidade Federal do Pará |
| collection |
RI-UFPA |
| language |
eng |
| topic |
Amazônia brasileira Tratamento Malária falciparum Quinina |
| spellingShingle |
Amazônia brasileira Tratamento Malária falciparum Quinina VIEIRA, José Luiz Fernandes Quinine levels in patients with uncomplicated falciparum malaria in the Amazon region of Brazil |
| topic_facet |
Amazônia brasileira Tratamento Malária falciparum Quinina |
| description |
We examined the plasmatic concentrations of quinine in patients with uncomplicated falciparum malaria in an endemic area of the Amazon region in Brazil in a prospective clinical trial, in which a standard three-day course of oral quinine plus doxycycline was used. We measured the quinine in the plasma samples on days 0 and 3by high performance liquid chromatography. The mean concentration of quinine was 6.04 ±2.21 µg/mL in male patients and 5.98 ±1.95 µg/mL in female patients. No significant differences in quinine concentration were observed between these two groups. All samples collected before starting treatment were negative for quinine. This information could help in the development of strategies for the rational use of antimalarial drugs in Brazil. |
| format |
Artigo |
| author |
VIEIRA, José Luiz Fernandes |
| author2 |
BORGES, Larissa Maria Guimarães NASCIMENTO, Margareth Tavares Silva GOMES, Andreza de Lourdes Souza |
| author2Str |
BORGES, Larissa Maria Guimarães NASCIMENTO, Margareth Tavares Silva GOMES, Andreza de Lourdes Souza |
| title |
Quinine levels in patients with uncomplicated falciparum malaria in the Amazon region of Brazil |
| title_short |
Quinine levels in patients with uncomplicated falciparum malaria in the Amazon region of Brazil |
| title_full |
Quinine levels in patients with uncomplicated falciparum malaria in the Amazon region of Brazil |
| title_fullStr |
Quinine levels in patients with uncomplicated falciparum malaria in the Amazon region of Brazil |
| title_full_unstemmed |
Quinine levels in patients with uncomplicated falciparum malaria in the Amazon region of Brazil |
| title_sort |
quinine levels in patients with uncomplicated falciparum malaria in the amazon region of brazil |
| publishDate |
2011 |
| url |
http://www.repositorio.ufpa.br:8080/jspui/handle/2011/2428 |
| _version_ |
1832603089347018752 |
| score |
11.755432 |