Quadro clínico-patológico do envenenamento crotálico experimental em bubalinos comparado com o de bovinos
The objective of the study was to verify the sensibility of buffaloes to the poison of Cro- talus durissus terri icus and to study the clinical-pathological picture in buffaloes in com- parison with the one in cattle. The subcutaneous inoculation of the lio ilized poison of the s...
| Autor principal: | BARBOSA NETO, José Diomedes |
|---|---|
| Outros Autores: | SOUSA, Melina Garcia Saraiva de, TOKARNIA, Carlos Maria Antônio Hubinger, BRITO, Marilene de Farias, REIS, Alessandra dos Santos Belo, BOMJARDIM, Henrique dos Anjos, LOPES, Cinthia Távora de Albuquerque, OLIVEIRA, Carlos Magno Chaves |
| Grau: | Artigo |
| Idioma: | por |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: |
http://repositorio.ufpa.br/jspui/2011/2503 |
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ir-2011-2503 |
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ir-2011-25032019-05-23T11:31:55Z Quadro clínico-patológico do envenenamento crotálico experimental em bubalinos comparado com o de bovinos Comparison between the clinical and pathological picture in the experimental poisoning by crotalic venom BARBOSA NETO, José Diomedes SOUSA, Melina Garcia Saraiva de TOKARNIA, Carlos Maria Antônio Hubinger BRITO, Marilene de Farias REIS, Alessandra dos Santos Belo BOMJARDIM, Henrique dos Anjos LOPES, Cinthia Távora de Albuquerque OLIVEIRA, Carlos Magno Chaves Pará - Estado Amazônia brasileira Mordedura de serpente Bovino Búfalo Envenenamento Crotalus durissus terrificus Castanhal - PA The objective of the study was to verify the sensibility of buffaloes to the poison of Cro- talus durissus terri icus and to study the clinical-pathological picture in buffaloes in com- parison with the one in cattle. The subcutaneous inoculation of the lio ilized poison of the snake, diluted in 1ml of physiologic solution, was done in the area of the humerus-radio- -ulnar joint of three buffaloes at doses of 0.015, 0.03 and 0.066mg/kg, and of two cattle at doses of 0.03 and 0.066mg/kg. The buffalo that received the 0.03mg/kg dose presented severe clinical signs but recovered six days later. The bovine that received the same dose, died after a clinical course of 22h56min. The 0.066mg/kg dose caused death of the bovine as also the buffalo, with a clinical course of 4h23min and 8h12min, respectively. The bu- ffalo that received the 0.015mg/kg dose recovered, after a course of 48 hours. The buffalo that died, showed clinical signs from 3h58min on, and the buffaloes that showed symp- toms from 17h25min and 24h00min after inoculation of the venom, but recovered. In the two cattle that died (with doses of 0.03 and 0.066mg/kg), the irst clinical signs occurred 6h10min and 6h31min after the inoculation of the venom. The inoculation produced in the buffaloes and cattle nervous symptoms of laccid paralysis. The main signs observed in the buffaloes as well as the cattle, were slight volume increase at the site of inoculation, respiration dif iculties characterized by predominantly abdominal breathing, apathy, sia- lorreia, dif iculty to get up when stimulated, evolution to sternal decubitus followed by lateral decubitus with peddling movements of the legs, and decrease of the re lexes related to the cranial nerves. The buffaloes showed also augmentation of the sustentation base, dragging of the hooves of the hind legs, slow and staggering gait, dif iculty in apprehension of the food, The cattle showed additionally paralysis of the eyeballs, revealed through non- -exhibition of the sclera during head rotation in latero-caudal direction. Laboratory exams revealed in the cattle and the buffaloes leucocytosis by neutro ilia, and in the biochemis- try series, increase in the levels of alanine aminotransferase, aspartato aminotransferase, creatinaquinase and lactic dehydrogenase. There was no alteration in the urinalysis nor in the activation time of protrombine and in the time of partially activated tromboplastin. Necropsy only evidenced slight edema corresponding to the inoculation site in one bovine. Histopathological examination revealed picnosis of the epitelial cell nuclei of some kidney tubules in the cortex (in the buffalo and in one bovine) and slight vacuolation of hepatocites (in one bovine). O estudo teve por objetivo verificar a sensibilidade dos bubalinos à peçonha de Crotalus durissus terriiicus, estudar o quadro clínico-patológico e laboratorial nessa espécie e estabelecer comparações com o verificado em bovinos. A inoculação do veneno liofilizado de Crotalus durissus terriiicus, diluído em 1ml de solução fisiológica, foi feita na região da articulação úmero-rádio-ulnar, por via subcutânea, em três bubalinos (doses de 0,015; 0,03; e 0,066mg/kg) e em dois bovinos (doses de 0,03 e 0,066mg/kg). O bubalino que recebeu a dose de 0,03mg/ kg apresentou sinais clínicos graves recuperou-se seis dias após, e o bovino que recebeu a mesma dose morreu com evolução de 22h56min. A dose de 0,066mg/kg causou a morte tanto do bovino quanto do bubalino, com evolução clínica de 4h23min e 8h12min, respectivamente. O bubalino que recebeu a dose de 0,015mg/kg, recuperou-se com evolução de 48 horas. Os sinais clínicos tiveram início dentro de 3h58min no bubalino que morreu, e nos bubalinos que adoeceram mas se recuperaram, dentro de 17h25min e 24h00min após a inoculação do veneno. Nos dois bovinos que morreram (com doses de 0,03 e 0,066mg/kg), os primeiros sinais clínicos foram observados 6h10min e 6h31min após a inoculação do veneno. A inoculação do veneno produziu nos búfalos e bovinos um quadro nervoso de paralisia flácida. Os principais sinais observados tanto nos búfalos quanto nos bovinos, foram discreto aumento de volume no local da inoculação, dificuldade respiratória caracterizada por respiração predominantemente abdominal, apatia, sialorreia, dificuldade para se levantar quando estimulados, evolução para decúbito esternal permanente, seguido de decúbito lateral e movimentos de pedalagem, e diminuição dos reflexos relacionados aos pares de nervos cranianos. Nos bubalinos adicionalmente foi observado aumento da base de sustentação, arrastar das pinças dos membros posteriores, marcha lenta e cambaleante, dificuldade na apreensão dos alimentos; nos bovinos ainda foram observados paralisia do globo ocular, revelada através da não exposição da esclera durante a rotação da cabeça na direção latero-caudal. Tanto nos bovinos quanto nos bubalinos, verificou-se no leucograma, leucocitose por neutrofilia, e na bioquímica sérica, aumento nos níveis de alanina aminotransferase, aspartato aminotransferase, creatinaquinase e dehidrogenase láctica. Não houve alterações na urinálise, nem no tempo de ativação da protrombina e nem no tempo de tromboplastina parcial ativada. À necropsia evidenciou-se apenas discreto edema correspondente ao local da inoculação em um bovino. Os achados histopatológicos observados foram picnose nos núcleos de células epiteliais de alguns túbulos uriníferos no córtex renal (em um búfalo e um bovino) e fígado com leve vacuolização de hepatócitos (em um bovino). 2012-03-02T19:06:51Z 2012-03-02T19:06:51Z 2011-11 Artigo de Periódico BARBOSA, José Diomedes et al. Quadro clínico-patológico do envenenamento crotálico experimental em bubalinos comparado com o de bovinos. Pesquisa Veterinária Brasileira, Rio de Janeiro, v. 31, n. 11, p. 967-973, nov. 2011. Disponível em: <http://www.scielo.br/pdf/pvb/v31n11/a05v31n11.pdf>. Acesso em: 02 mar. 2012. <http://dx.doi.org/10.1590/S0100-736X2011001100005>. 0100-736X http://repositorio.ufpa.br/jspui/2011/2503 por Acesso Aberto application/pdf |
| institution |
Repositório Institucional - Universidade Federal do Pará |
| collection |
RI-UFPA |
| language |
por |
| topic |
Pará - Estado Amazônia brasileira Mordedura de serpente Bovino Búfalo Envenenamento Crotalus durissus terrificus Castanhal - PA |
| spellingShingle |
Pará - Estado Amazônia brasileira Mordedura de serpente Bovino Búfalo Envenenamento Crotalus durissus terrificus Castanhal - PA BARBOSA NETO, José Diomedes Quadro clínico-patológico do envenenamento crotálico experimental em bubalinos comparado com o de bovinos |
| topic_facet |
Pará - Estado Amazônia brasileira Mordedura de serpente Bovino Búfalo Envenenamento Crotalus durissus terrificus Castanhal - PA |
| description |
The objective of the study was to verify the sensibility of buffaloes to the poison of
Cro-
talus durissus terri icus
and to study the clinical-pathological picture in buffaloes in com-
parison with the one in cattle. The subcutaneous inoculation of the lio ilized poison of the
snake, diluted in 1ml of physiologic solution, was done in the area of the humerus-radio-
-ulnar joint of three buffaloes at doses of 0.015, 0.03 and 0.066mg/kg, and of two cattle at
doses of 0.03 and 0.066mg/kg. The buffalo that received the 0.03mg/kg dose presented
severe clinical signs but recovered six days later. The bovine that received the same dose,
died after a clinical course of 22h56min. The 0.066mg/kg dose caused death of the bovine
as also the buffalo, with a clinical course of 4h23min and 8h12min, respectively. The bu-
ffalo that received the 0.015mg/kg dose recovered, after a course of 48 hours. The buffalo
that died, showed clinical signs from 3h58min on, and the buffaloes that showed symp-
toms from 17h25min and 24h00min after inoculation of the venom, but recovered. In the
two cattle that died (with doses of 0.03 and 0.066mg/kg), the irst clinical signs occurred
6h10min and 6h31min after the inoculation of the venom. The inoculation produced in
the buffaloes and cattle nervous symptoms of laccid paralysis. The main signs observed
in the buffaloes as well as the cattle, were slight volume increase at the site of inoculation,
respiration dif iculties characterized by predominantly abdominal breathing, apathy, sia-
lorreia, dif iculty to get up when stimulated, evolution to sternal decubitus followed by
lateral decubitus with peddling movements of the legs, and decrease of the re lexes related
to the cranial nerves. The buffaloes showed also augmentation of the sustentation base,
dragging of the hooves of the hind legs, slow and staggering gait, dif iculty in apprehension
of the food, The cattle showed additionally paralysis of the eyeballs, revealed through non-
-exhibition of the sclera during head rotation in latero-caudal direction. Laboratory exams
revealed in the cattle and the buffaloes leucocytosis by neutro ilia, and in the biochemis-
try series, increase in the levels of alanine aminotransferase, aspartato aminotransferase,
creatinaquinase and lactic dehydrogenase. There was no alteration in the urinalysis nor in the activation time of protrombine and in the time of partially activated tromboplastin.
Necropsy only evidenced slight edema corresponding to the inoculation site in one bovine.
Histopathological examination revealed picnosis of the epitelial cell nuclei of some kidney
tubules in the cortex (in the buffalo and in one bovine) and slight vacuolation of hepatocites
(in one bovine). |
| format |
Artigo |
| author |
BARBOSA NETO, José Diomedes |
| author2 |
SOUSA, Melina Garcia Saraiva de TOKARNIA, Carlos Maria Antônio Hubinger BRITO, Marilene de Farias REIS, Alessandra dos Santos Belo BOMJARDIM, Henrique dos Anjos LOPES, Cinthia Távora de Albuquerque OLIVEIRA, Carlos Magno Chaves |
| author2Str |
SOUSA, Melina Garcia Saraiva de TOKARNIA, Carlos Maria Antônio Hubinger BRITO, Marilene de Farias REIS, Alessandra dos Santos Belo BOMJARDIM, Henrique dos Anjos LOPES, Cinthia Távora de Albuquerque OLIVEIRA, Carlos Magno Chaves |
| title |
Quadro clínico-patológico do envenenamento crotálico experimental em bubalinos comparado com o de bovinos |
| title_short |
Quadro clínico-patológico do envenenamento crotálico experimental em bubalinos comparado com o de bovinos |
| title_full |
Quadro clínico-patológico do envenenamento crotálico experimental em bubalinos comparado com o de bovinos |
| title_fullStr |
Quadro clínico-patológico do envenenamento crotálico experimental em bubalinos comparado com o de bovinos |
| title_full_unstemmed |
Quadro clínico-patológico do envenenamento crotálico experimental em bubalinos comparado com o de bovinos |
| title_sort |
quadro clínico-patológico do envenenamento crotálico experimental em bubalinos comparado com o de bovinos |
| publishDate |
2012 |
| url |
http://repositorio.ufpa.br/jspui/2011/2503 |
| _version_ |
1832602591059509248 |
| score |
11.755432 |