Enriched environment contributes to recovery of visual acuity and increases perineuronal nets in monocular-deprived animals
The aim of the present study was to analyze the influence of enriched environment on the distribution of perineuronal nets (PNNs) using a stereogically based unbiased protocol and visual acuity in adult Swiss albino mice that underwent monocular deprivation during the critical period of postnatal de...
| Autor principal: | TRÉVIA, Nonata |
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| Outros Autores: | ALMEIDA, Izabela Negrão Frota de, OLIVEIRA, Poliana Sampaio, WARWICK, Laura Vianna, MARQUES, Viviane, SANTOS, Denise Cristina dos, VIEGAS, Maria Luana Carvalho, DINIZ, Cristovam Wanderley Picanço, PAULO, Dario Carvalho |
| Grau: | Artigo |
| Idioma: | eng |
| Publicado em: |
2012
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| Acesso em linha: |
http://repositorio.ufpa.br/jspui/handle/2011/2605 |
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ir-2011-2605 |
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ir-2011-26052018-01-30T15:00:14Z Enriched environment contributes to recovery of visual acuity and increases perineuronal nets in monocular-deprived animals TRÉVIA, Nonata ALMEIDA, Izabela Negrão Frota de OLIVEIRA, Poliana Sampaio WARWICK, Laura Vianna MARQUES, Viviane SANTOS, Denise Cristina dos VIEGAS, Maria Luana Carvalho DINIZ, Cristovam Wanderley Picanço PAULO, Dario Carvalho Acuidade visual Córtex visual Visão monocular Período crítico (Psicologia) The aim of the present study was to analyze the influence of enriched environment on the distribution of perineuronal nets (PNNs) using a stereogically based unbiased protocol and visual acuity in adult Swiss albino mice that underwent monocular deprivation during the critical period of postnatal development. Eight female Swiss albino mice were monocular deprived were removed and cut at 70 µm thickness in a vibratome and processed for lectin histochemical staining with Wisteria floribunda agglutinin (WFA). Architectonic limits of area 17 were conspicuously defined by WFA histochemical staining, and the optical fractionator stereological method was applied to estimate the total number of PNNs in the supragranular, granular, and infragranular layers. All groups were compared using Student's t-test at a 95% confidence level. Comparative analysis of the average PNN estimations revealed that the EE group had higher PNNs in the supragranular layer (2726.33 ± 405.416, mean ± standard deviation) compared with the SE group (1543.535 ± 260.686; Student's t-test, p = .0495). No differences were found in the other layers. Visual acuity was significantly lower in the SE group (0.55 cycles/degree) than in the EE group (1.06 cycles/degree). Our results suggest that the integrity of the specialized extracellular matrix PNNs of the supragranular layer may be essential for normal visual acuity development. 2012-04-10T18:34:30Z 2012-04-10T18:34:30Z 2001-06 Artigo de Periódico TREVIA, Nonata et al. Enriched environment contributes to recovery of visual acuity and increases perineuronal nets in monocular-deprived animals. Psychology & Neuroscience, Rio de Janeiro, v. 4, n. 1, p. 49-56, jun. 2011. Disponível em: <http://www.scielo.br/pdf/pn/v4n1/06.pdf>. Acesso em: 03 abr. 2012. <http://dx.doi.org/10.3922/j.psns.2011.1.006>. 1983-3288 http://repositorio.ufpa.br/jspui/handle/2011/2605 eng Acesso Aberto application/pdf |
| institution |
Repositório Institucional - Universidade Federal do Pará |
| collection |
RI-UFPA |
| language |
eng |
| topic |
Acuidade visual Córtex visual Visão monocular Período crítico (Psicologia) |
| spellingShingle |
Acuidade visual Córtex visual Visão monocular Período crítico (Psicologia) TRÉVIA, Nonata Enriched environment contributes to recovery of visual acuity and increases perineuronal nets in monocular-deprived animals |
| topic_facet |
Acuidade visual Córtex visual Visão monocular Período crítico (Psicologia) |
| description |
The aim of the present study was to analyze the influence of enriched environment on the distribution of perineuronal nets (PNNs) using a stereogically based unbiased protocol and visual acuity in adult Swiss albino mice that underwent monocular deprivation during the critical period of postnatal development. Eight female Swiss albino mice were monocular deprived were removed and cut at 70 µm thickness in a vibratome and processed for lectin histochemical staining with Wisteria floribunda agglutinin (WFA). Architectonic limits of area 17 were conspicuously defined by WFA histochemical staining, and the optical fractionator stereological method was applied to estimate the total number of PNNs in the supragranular, granular, and infragranular layers. All groups were compared using Student's t-test at a 95% confidence level. Comparative analysis of the average PNN estimations revealed that the EE group had higher PNNs in the supragranular layer (2726.33 ± 405.416, mean ± standard deviation) compared with the SE group (1543.535 ± 260.686; Student's t-test, p = .0495). No differences were found in the other layers. Visual acuity was significantly lower in the SE group (0.55 cycles/degree) than in the EE group (1.06 cycles/degree). Our results suggest that the integrity of the specialized extracellular matrix PNNs of the supragranular layer may be essential for normal visual acuity development. |
| format |
Artigo |
| author |
TRÉVIA, Nonata |
| author2 |
ALMEIDA, Izabela Negrão Frota de OLIVEIRA, Poliana Sampaio WARWICK, Laura Vianna MARQUES, Viviane SANTOS, Denise Cristina dos VIEGAS, Maria Luana Carvalho DINIZ, Cristovam Wanderley Picanço PAULO, Dario Carvalho |
| author2Str |
ALMEIDA, Izabela Negrão Frota de OLIVEIRA, Poliana Sampaio WARWICK, Laura Vianna MARQUES, Viviane SANTOS, Denise Cristina dos VIEGAS, Maria Luana Carvalho DINIZ, Cristovam Wanderley Picanço PAULO, Dario Carvalho |
| title |
Enriched environment contributes to recovery of visual acuity and increases perineuronal nets in monocular-deprived animals |
| title_short |
Enriched environment contributes to recovery of visual acuity and increases perineuronal nets in monocular-deprived animals |
| title_full |
Enriched environment contributes to recovery of visual acuity and increases perineuronal nets in monocular-deprived animals |
| title_fullStr |
Enriched environment contributes to recovery of visual acuity and increases perineuronal nets in monocular-deprived animals |
| title_full_unstemmed |
Enriched environment contributes to recovery of visual acuity and increases perineuronal nets in monocular-deprived animals |
| title_sort |
enriched environment contributes to recovery of visual acuity and increases perineuronal nets in monocular-deprived animals |
| publishDate |
2012 |
| url |
http://repositorio.ufpa.br/jspui/handle/2011/2605 |
| _version_ |
1832603562494918656 |
| score |
11.755432 |