Does plasma ANP participate in natriuresis induced by a-MSH?
-Melanocyte-stimulating hormone (-MSH; 0.6 and 3 nmol) microinjected into the anteroventral region of the third ventricle (AV3V) induced a significant increase in diuresis without modifying natriuresis or kaliuresis. Intraperitoneal (ip) injection of -MSH (3 and 9.6 nmol) induced a significant in...
| Autor principal: | DINIZ, Domingos Luiz Wanderley Picanço |
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| Outros Autores: | OLIVEIRA, Gustavo Ribeiro de, FAVARETTO, Ana Lucia Vianna, GUTKOWSKA, J., MCCANN, S.M., RODRIGUES, José Antunes |
| Grau: | Artigo |
| Idioma: | eng |
| Publicado em: |
2012
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| Acesso em linha: |
http://repositorio.ufpa.br/jspui/handle/2011/3290 |
| Resumo: |
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-Melanocyte-stimulating hormone (-MSH; 0.6 and 3 nmol) microinjected into the anteroventral region of the third ventricle (AV3V) induced a significant increase in diuresis without modifying natriuresis or kaliuresis. Intraperitoneal (ip) injection of -MSH (3 and 9.6 nmol) induced a significant increase in urinary sodium, potassium and water excretion. Intraperitoneal (3 and 4.8 nmol) or iv (3 and 9.6 nmol) administration of -MSH did not induce any significant changes in plasma atrial natriuretic peptide (ANP), suggesting that the natriuresis, kaliuresis and diuresis induced by the systemic action of -MSH can be dissociated from the increase in plasma ANP. These preliminary results suggest that -MSH may be involved in a -MSHindependent mechanism of regulation of hydromineral metabolism. |