Evaluation of antinociceptive and antiinflammatory effects of Croton pullei var. glabrior Lanj. (Euphorbiaceae)
Croton pullei var. glabrior Lanj. (Euphorbiaceae) is a liana, vastly distributed in the Amazonian Forest. In the folk medicine, several plants of the Croton genus have been used with therapeutic purposes in pathologies that involve painful and inflammatory diseases which justify this work. The aim o...
| Autor principal: | ROCHA, Fabio Fagundes da |
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| Outros Autores: | NEVES, Evandro Manoel Neto, COSTA, Elson Alves, MATOS, Lécia Garcia de, MÜLLER, Adolfo Henrique, GUILHON, Giselle Maria Skelding Pinheiro, CORTES, Wellington da Silva, VANDERLINDE, Frederico Argollo |
| Grau: | Artigo |
| Idioma: | eng |
| Publicado em: |
2013
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| Acesso em linha: |
http://repositorio.ufpa.br/jspui/handle/2011/3939 |
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ir-2011-3939 |
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ir-2011-39392019-05-23T13:25:53Z Evaluation of antinociceptive and antiinflammatory effects of Croton pullei var. glabrior Lanj. (Euphorbiaceae) Avaliação dos efeitos antinociceptivo e antiinflamatório de Croton pullei var. glabrior Lanj. (Euphorbiaceae) ROCHA, Fabio Fagundes da NEVES, Evandro Manoel Neto COSTA, Elson Alves MATOS, Lécia Garcia de MÜLLER, Adolfo Henrique GUILHON, Giselle Maria Skelding Pinheiro CORTES, Wellington da Silva VANDERLINDE, Frederico Argollo Agentes antiinflamatórios Analgésicos Crotton pullei Medicina fitoterápica Peixe-boi - PA Pará - Estado Amazônia brasileira Croton pullei var. glabrior Lanj. (Euphorbiaceae) is a liana, vastly distributed in the Amazonian Forest. In the folk medicine, several plants of the Croton genus have been used with therapeutic purposes in pathologies that involve painful and inflammatory diseases which justify this work. The aim of this study was to investigate the antinociceptive and antiinflammatory activities of the C. pullei leaves methanol extract (MECP). MECP reduced in a dose-dependent manner the number of acetic acid-induced abdominal writhing (1.2%) in mice, suggesting an antinociceptive activity of the plant. On the other hand, MECP did not significantly modify the reactivity to the thermal stimulation in the hot-plate test and the reactivity to the chemical stimulation in the formalin test first phase, indicating a non-opioid mechanism. MECP reduced the formalin-induced nociception in the second phase, inhibited the croton oil-induced ear edema and reduced the leukocytes migration in the test of the carrageenan-induced peritonitis, indicating an antiinflammatory activity. Although the mechanisms that underlie these plant effects are not completely elucidated, these results appear to support the potential medicinal use of Croton pullei var. glabrior Lanj. against painful and inflammatory diseases. Croton pullei var. glabrior Lanj. (Euphorbiaceae) é uma liana, amplamente distribuída na Floresta Amazônica. Na medicina popular, diversas plantas do gênero Croton têm sido utilizadas com fins terapêuticos em patologias que envolvem dor e inflamação, o que justifica este trabalho. O objetivo deste estudo foi investigar as atividades antinociceptiva e do extrato metanólico das folhas de C. pullei (MECP). O MECP reduziu, de forma dose-dependente, o número de contorções abdominais (1,2 %) em camundongos, sugerindo uma atividade antinociceptiva da planta. Por outro lado, o MECP não alterou significativamente a reatividade ao estímulo térmico no teste da placa quente e a reatividade à estimulação química na primeira fase do teste da formalina, indicando um mecanismo não-opioidérgico. O MECP reduziu a nocicepção na segunda fase do teste da formalina, inibiu o edema de orelha induzido pelo óleo de croton e reduziu a migração leucocitária no teste da peritonite induzida por carragenina, indicando uma atividade antiinflamatória. Apesar dos mecanismos responsáveis pelos efeitos da planta ainda não estarem completamente esclarecidos, estes resultados parecem justificar o uso medicinal potencial de Croton pullei var. glabrior Lanj. em patologias que envolvam dor e inflamação. 2013-05-29T17:57:52Z 2013-05-29T17:57:52Z 2008-09 Artigo de Periódico ROCHA, Fábio F., et al. Evaluation of antinociceptive and antiinflammatory effects of Croton pullei var. glabrior Lanj. (Euphorbiaceae). Revista Brasileira de Farmacognosia, João Pessoa, v. 18, n. 3, p. 344-349, jul./set. 2008. Disponível em: <http://www.scielo.br/pdf/rbfar/v18n3/a06v18n3.pdf>. Acesso em: 29 maio 2013. <http://dx.doi.org/10.1590/S0102-695X2008000300006>. 0102-695X http://repositorio.ufpa.br/jspui/handle/2011/3939 eng Acesso Aberto application/pdf |
| institution |
Repositório Institucional - Universidade Federal do Pará |
| collection |
RI-UFPA |
| language |
eng |
| topic |
Agentes antiinflamatórios Analgésicos Crotton pullei Medicina fitoterápica Peixe-boi - PA Pará - Estado Amazônia brasileira |
| spellingShingle |
Agentes antiinflamatórios Analgésicos Crotton pullei Medicina fitoterápica Peixe-boi - PA Pará - Estado Amazônia brasileira ROCHA, Fabio Fagundes da Evaluation of antinociceptive and antiinflammatory effects of Croton pullei var. glabrior Lanj. (Euphorbiaceae) |
| topic_facet |
Agentes antiinflamatórios Analgésicos Crotton pullei Medicina fitoterápica Peixe-boi - PA Pará - Estado Amazônia brasileira |
| description |
Croton pullei var. glabrior Lanj. (Euphorbiaceae) is a liana, vastly distributed in the Amazonian Forest. In the folk medicine, several plants of the Croton genus have been used with therapeutic purposes in pathologies that involve painful and inflammatory diseases which justify this work. The aim of this study was to investigate the antinociceptive and antiinflammatory activities of the C. pullei leaves methanol extract (MECP). MECP reduced in a dose-dependent manner the number of acetic acid-induced abdominal writhing (1.2%) in mice, suggesting an antinociceptive activity of the plant. On the other hand, MECP did not significantly modify the reactivity to the thermal stimulation in the hot-plate test and the reactivity to the chemical stimulation in the formalin test first phase, indicating a non-opioid mechanism. MECP reduced the formalin-induced nociception in the second phase, inhibited the croton oil-induced ear edema and reduced the leukocytes migration in the test of the carrageenan-induced peritonitis, indicating an antiinflammatory activity. Although the mechanisms that underlie these plant effects are not completely elucidated, these results appear to support the potential medicinal use of Croton pullei var. glabrior Lanj. against painful and inflammatory diseases. |
| format |
Artigo |
| author |
ROCHA, Fabio Fagundes da |
| author2 |
NEVES, Evandro Manoel Neto COSTA, Elson Alves MATOS, Lécia Garcia de MÜLLER, Adolfo Henrique GUILHON, Giselle Maria Skelding Pinheiro CORTES, Wellington da Silva VANDERLINDE, Frederico Argollo |
| author2Str |
NEVES, Evandro Manoel Neto COSTA, Elson Alves MATOS, Lécia Garcia de MÜLLER, Adolfo Henrique GUILHON, Giselle Maria Skelding Pinheiro CORTES, Wellington da Silva VANDERLINDE, Frederico Argollo |
| title |
Evaluation of antinociceptive and antiinflammatory effects of Croton pullei var. glabrior Lanj. (Euphorbiaceae) |
| title_short |
Evaluation of antinociceptive and antiinflammatory effects of Croton pullei var. glabrior Lanj. (Euphorbiaceae) |
| title_full |
Evaluation of antinociceptive and antiinflammatory effects of Croton pullei var. glabrior Lanj. (Euphorbiaceae) |
| title_fullStr |
Evaluation of antinociceptive and antiinflammatory effects of Croton pullei var. glabrior Lanj. (Euphorbiaceae) |
| title_full_unstemmed |
Evaluation of antinociceptive and antiinflammatory effects of Croton pullei var. glabrior Lanj. (Euphorbiaceae) |
| title_sort |
evaluation of antinociceptive and antiinflammatory effects of croton pullei var. glabrior lanj. (euphorbiaceae) |
| publishDate |
2013 |
| url |
http://repositorio.ufpa.br/jspui/handle/2011/3939 |
| _version_ |
1787147951591653376 |
| score |
11.653393 |