Influence of late treatment on how chronic myeloid leukemia responds to imatinib
INTRODUCTION: In Brazil, patients with chronic myeloid leukemia (CML) in the chronic phase were not given first-line imatinib treatment until 2008. Therefore, there was a long period of time between diagnosis and the initiation of imatinib therapy for many patients. This study aims to compare the ma...
| Autor principal: | SCERNI, Ana Carolina Costa |
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| Outros Autores: | ALVARES, Leonardo Azevedo, BELTRÃO, Ana Cristina, BENTES, Iê Regina, AZEVEDO, Tereza Cristina, BENTES, Alessandra Quinto, LEMOS, José Alexandre Rodrigues de |
| Grau: | Artigo |
| Idioma: | eng |
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2013
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http://repositorio.ufpa.br/jspui/handle/2011/4312 |
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ir-2011-4312 |
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ir-2011-43122018-01-29T16:56:07Z Influence of late treatment on how chronic myeloid leukemia responds to imatinib SCERNI, Ana Carolina Costa ALVARES, Leonardo Azevedo BELTRÃO, Ana Cristina BENTES, Iê Regina AZEVEDO, Tereza Cristina BENTES, Alessandra Quinto LEMOS, José Alexandre Rodrigues de Leucemia mielogênica crônica BCR-ABL Tratamento tardio Imatinib Remissão molecular INTRODUCTION: In Brazil, patients with chronic myeloid leukemia (CML) in the chronic phase were not given first-line imatinib treatment until 2008. Therefore, there was a long period of time between diagnosis and the initiation of imatinib therapy for many patients. This study aims to compare the major molecular remission (MMR) rates of early versus late imatinib therapy in chronic phase CML patients. METHODS: Between May 2002 and November 2007, 44 patients with chronic phase CML were treated with second-line imatinib therapy at the Hematology Unit of the Ophir Loyola Hospital (Belém, Pará, Brazil). BCR-ABL transcript levels were measured at approximately six-month intervals using quantitative polymerase chain reaction. RESULTS: The early treatment group presented a 60% probability of achieving MMR, while the probability for those patients who received late treatment was 40%. The probability of either not achieving MMR within one year of the initiation of imatinib therapy or losing MMR was higher in patients who received late treatment (79%), compared with patients who received early treatment (21%, odds ratio=5.75, P=0.012). The probability of maintaining MMR at 30 months of treatment was 80% in the early treatment group and 44% in the late treatment group (P=0.0005). CONCLUSIONS: For CML patients in the chronic phase who were treated with second-line imatinib therapy, the probability of achieving and maintaining MMR was higher in patients who received early treatment compared with those patients for whom the time interval between diagnosis and initiation of imatinib therapy was longer than one year. 2013-09-30T16:33:31Z 2013-09-30T16:33:31Z 2009 Artigo de Periódico SCERNI, Ana Carolina Costa, et al. Influence of late treatment on how chronic myeloid leukemia responds to imatinib. Clinics, São Paulo, v. 64, n. 8, p. 731-734, 2009. Disponível em: <http://www.scielo.br/pdf/clin/v64n8/a04v64n8.pdf>. Acesso em: 30 set. 2013. <http://dx.doi.org/10.1590/S1807-59322009000800004>. 1980-5322 1807-5932 http://repositorio.ufpa.br/jspui/handle/2011/4312 eng Acesso Aberto application/pdf |
| institution |
Repositório Institucional - Universidade Federal do Pará |
| collection |
RI-UFPA |
| language |
eng |
| topic |
Leucemia mielogênica crônica BCR-ABL Tratamento tardio Imatinib Remissão molecular |
| spellingShingle |
Leucemia mielogênica crônica BCR-ABL Tratamento tardio Imatinib Remissão molecular SCERNI, Ana Carolina Costa Influence of late treatment on how chronic myeloid leukemia responds to imatinib |
| topic_facet |
Leucemia mielogênica crônica BCR-ABL Tratamento tardio Imatinib Remissão molecular |
| description |
INTRODUCTION: In Brazil, patients with chronic myeloid leukemia (CML) in the chronic phase were not given first-line imatinib treatment until 2008. Therefore, there was a long period of time between diagnosis and the initiation of imatinib therapy for many patients. This study aims to compare the major molecular remission (MMR) rates of early versus late imatinib therapy in chronic phase CML patients.
METHODS: Between May 2002 and November 2007, 44 patients with chronic phase CML were treated with second-line imatinib therapy at the Hematology Unit of the Ophir Loyola Hospital (Belém, Pará, Brazil). BCR-ABL transcript levels were measured at approximately six-month intervals using quantitative polymerase chain reaction.
RESULTS: The early treatment group presented a 60% probability of achieving MMR, while the probability for those patients who received late treatment was 40%. The probability of either not achieving MMR within one year of the initiation of imatinib therapy or losing MMR was higher in patients who received late treatment (79%), compared with patients who received early treatment (21%, odds ratio=5.75, P=0.012). The probability of maintaining MMR at 30 months of treatment was 80% in the early treatment group and 44% in the late treatment group (P=0.0005).
CONCLUSIONS: For CML patients in the chronic phase who were treated with second-line imatinib therapy, the probability of achieving and maintaining MMR was higher in patients who received early treatment compared with those patients for whom the time interval between diagnosis and initiation of imatinib therapy was longer than one year. |
| format |
Artigo |
| author |
SCERNI, Ana Carolina Costa |
| author2 |
ALVARES, Leonardo Azevedo BELTRÃO, Ana Cristina BENTES, Iê Regina AZEVEDO, Tereza Cristina BENTES, Alessandra Quinto LEMOS, José Alexandre Rodrigues de |
| author2Str |
ALVARES, Leonardo Azevedo BELTRÃO, Ana Cristina BENTES, Iê Regina AZEVEDO, Tereza Cristina BENTES, Alessandra Quinto LEMOS, José Alexandre Rodrigues de |
| title |
Influence of late treatment on how chronic myeloid leukemia responds to imatinib |
| title_short |
Influence of late treatment on how chronic myeloid leukemia responds to imatinib |
| title_full |
Influence of late treatment on how chronic myeloid leukemia responds to imatinib |
| title_fullStr |
Influence of late treatment on how chronic myeloid leukemia responds to imatinib |
| title_full_unstemmed |
Influence of late treatment on how chronic myeloid leukemia responds to imatinib |
| title_sort |
influence of late treatment on how chronic myeloid leukemia responds to imatinib |
| publishDate |
2013 |
| url |
http://repositorio.ufpa.br/jspui/handle/2011/4312 |
| _version_ |
1787147547658158080 |
| score |
11.678145 |