The Eupatorium ayapana Vent., Family Asteraceae, popularly known as
japana is used in infusions, decoctions, baths and tea, with sedative, febrifuge,
stimulant and tonic, also used to combat insomnia, headache, sore throat, diarrhea,
etc.., commonly used by the Amazonian population. This study evaluated the effect
of different doses of hydroalcoholic extract of Eupatorium ayapana Vent (EHAEA) on
the behavior of Wistar rats, aged 2 months. We used eight groups of rats (n = 7-10)
that were divided into control, standard drug action anxiolytic (diazepam), standard
drug action antidepressant (fluoxetine) and five doses of the extract (100, 200, 400,
600, 800 mg/kg) which were solubilized with 1% tween 80. The administration of the
extract was performed acutely by gavage. In oral toxicity test, it was found that the
extract is not toxic. The behavioral tests were used: the open field, the elevated plus
maze (EPM) and forced swimming. After the behavioral tests was performed to
collect blood in the retro-orbital plexus of rats to assess the levels of oxidative stress
such as Total Antioxidant Capacity, MDA and NO, and also the total antioxidant
EHAEA. The results obtained in the open field test showed anxiolytic-like activity, a
result confirmed in the LCE. In the forced swimming test, the EHAEA showed
antidepressant action of any kind. In tests of nociception, which was used mice
occurred in antinociceptive abdominal writhing test in doses of 200, 400, 600 and 800
mg/kg. In evaluating the biochemical oxidation, it was observed that there was no
oxidative damage in the treated groups EHAEA, NO levels were unchanged at doses
of 200, 400 and 600 mg total antioxidant capacity was shown to be increased. With
these results, this paper aims to contribute to future work, have seen, are few studies
in the behavioral area, in nociception and oxidative stress in this plant species, and
that further studies may enhance the use of the extract in folk medicine japana.
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