Ameloblastoma and calcifying cystic odontogenic tumor (CCOT) are odontogenic
tumors with origin odontogenic epithelium, but it is not yet known stimulus or trigger
that lead to neoplastic transformation of tumors. The biological behavior of the
lesions is distinct because the ameloblastoma is more aggressive and significant rate
of tumor recurrence. CCOT is a less aggressive tumor and recurrence rarely there
and therefore was used as a control in the study. Therefore, the complete elucidation
of the mechanisms by which these odontogenic tumors show such biological
behavior remains a challenge for researchers. The ADAMTS (A Disintegrin and
Metalloproteinase with thrombospondin) are metalloendopeptidases who are
dependent on zinc in its catalytic domain. These enzymes have catalytic activity
against a broad range of substrates including proteoglycans (aggrecan, brevican and
versican), which are proteins present in the extracellular matrix (ECM). The ADAMTS
exhibit structural features that confer great potential to display multiple functions.
Exhibit crucial role in various processes such as proliferation, adhesion, invasion and
cell signaling. Changes to these enzymes are present in various tumors, suggesting
that these proteins may be involved in the carcinogenic process in different ways.
Specifically, ADAMTS-1 has been correlated with tumorigenesis of some cancers
such as in breast, lung and pancreatic cancer. Like ADAMTS, aggrecan, versican
and brevican are expressed in various tumors and altered regulation of
proteoglycans may contribute to the development of carcinogenesis. In this work
ADAMTS-1, aggrecan, brevican and versican in ameloblastoma and CCOT were
studied, 20 cases of ameloblastoma and 6 cases of TOCC, used as controls were
included. We evaluated the expression of ADAMTS-1, aggrecan, brevican and
versican by immunohistochemical study and the marking areas were measured and
analyzed. To correlation analysis between the studied proteins used the Spearman
test. All samples of ameloblastoma expressed ADAMTS-1, aggrecan, brevican and
versican. All samples TOCC also expressed the same proteins, but in significantly
less than the amount ameloblastoma. The difference in expression of ADAMTS-1
and brevican in the epithelium of ameloblastoma and of TOCC was statistically
significant (p<0.0105). As the expression of aggrecan and versican, between
ameloblastoma and TOCC, in the epithelium was also statistically significant
(p<0.0067) and (p<0.0148), respectively. There was no correlation between the
proteins studied.
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