Anti-inflammatory and antinociceptive activities of Euterpe oleracea Mart., Arecaceae, oil

FAVACHO, Hugo Alexandre Silva; OLIVEIRA, Bianca R.; SANTOS, Kelem Costa dos; MEDEIROS, Benedito Júnior Lima de; SOUSA, Pergentino José da Cunha; PERAZZO, Fabio Ferreira; CARVALHO, José Carlos Tavares

Artigo

Anti-inflammatory and antinociceptive activities of Euterpe oleracea Mart., Arecaceae, oil

The oil of the fruits of Euterpe oleracea Mart., Arecaceae (OEO), was evaluated in models of inflammation and hyperalgesia in vivo to study its effects on these conditions. The experimental models contained the writhing test in mice, rat paw edema, granuloma test in rats, vascular permeability in ra...

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Autor principal:	FAVACHO, Hugo Alexandre Silva
Outros Autores:	OLIVEIRA, Bianca R., SANTOS, Kelem Costa dos, MEDEIROS, Benedito Júnior Lima de, SOUSA, Pergentino José da Cunha, PERAZZO, Fabio Ferreira, CARVALHO, José Carlos Tavares
Grau:	Artigo
Idioma:	eng
Publicado em:	2014
Assuntos:	Euterpe oleracea Açaí Agentes antiinflamatórios Analgésicos Óleo de palmeira Óleo de açaí
Acesso em linha:	http://repositorio.ufpa.br/jspui/handle/2011/5952

id	ir-2011-5952
recordtype	dspace
spelling	ir-2011-59522017-10-16T15:20:51Z Anti-inflammatory and antinociceptive activities of Euterpe oleracea Mart., Arecaceae, oil FAVACHO, Hugo Alexandre Silva OLIVEIRA, Bianca R. SANTOS, Kelem Costa dos MEDEIROS, Benedito Júnior Lima de SOUSA, Pergentino José da Cunha PERAZZO, Fabio Ferreira CARVALHO, José Carlos Tavares Euterpe oleracea Açaí Agentes antiinflamatórios Analgésicos Óleo de palmeira Óleo de açaí The oil of the fruits of Euterpe oleracea Mart., Arecaceae (OEO), was evaluated in models of inflammation and hyperalgesia in vivo to study its effects on these conditions. The experimental models contained the writhing test in mice, rat paw edema, granuloma test in rats, vascular permeability in rats, cell migration to the peritoneal cavity in rats and ear erythema induced by croton oil in mice. Doses of 500, 1000 and 1500 mg/kg of OEO were administered orally. The observed number of writhes was inhibited by 33.67, 45.88 and 55.58%, respectively. OEO produced a dose-dependent effect, with linear correlation coefficient R=0.99 (y=0.0219x+23.133), and the median effective dose found was 1226.8 mg/kg. The oral administration of 1226.8 mg/kg of OEO inhibited carrageenan-induced edema by 29.18% (p<0.05) when compared to the control group. The daily administration of OEO for six days inhibited the formation of granulomatous tissue by 36.66% (p<0.01). In ear erythema induced by croton oil, OEO presented a significant inhibition (37.9%). In the vascular permeability test, treatment with OEO decreased the response to histamine, inhibiting vascular permeability by 54.16%. In carrageenan-induced peritonitis, OEO reduced the number of neutrophils migrating compared to the control group by 80.14%. These results suggested that OEO has anti-inflammatory and antinociceptive activities, probably of peripheral origin and linked to prostaglandin biosynthesis inhibition. 2014-10-31T13:29:16Z 2014-10-31T13:29:16Z 2011-02 Artigo de Periódico FAVACHO, Hugo A. S. et al. Anti-inflammatory and antinociceptive activities of Euterpe oleracea Mart., Arecaceae, oil. Revista Brasileira de Farmacognosia, Curitiba, v. 21, n. 1, p. 105-114, fev. 2011. Disponível em: <http://www.scielo.br/pdf/rbfar/v21n1/aop0211.pdf>. Acesso em: 15 jul. 2014. <http://dx.doi.org/10.1590/S0102-695X2011005000007>. 0102-695X http://repositorio.ufpa.br/jspui/handle/2011/5952 eng Acesso Aberto application/pdf
institution	Repositório Institucional - Universidade Federal do Pará
collection	RI-UFPA
language	eng
topic	Euterpe oleracea Açaí Agentes antiinflamatórios Analgésicos Óleo de palmeira Óleo de açaí
spellingShingle	Euterpe oleracea Açaí Agentes antiinflamatórios Analgésicos Óleo de palmeira Óleo de açaí FAVACHO, Hugo Alexandre Silva Anti-inflammatory and antinociceptive activities of Euterpe oleracea Mart., Arecaceae, oil
topic_facet	Euterpe oleracea Açaí Agentes antiinflamatórios Analgésicos Óleo de palmeira Óleo de açaí
description	The oil of the fruits of Euterpe oleracea Mart., Arecaceae (OEO), was evaluated in models of inflammation and hyperalgesia in vivo to study its effects on these conditions. The experimental models contained the writhing test in mice, rat paw edema, granuloma test in rats, vascular permeability in rats, cell migration to the peritoneal cavity in rats and ear erythema induced by croton oil in mice. Doses of 500, 1000 and 1500 mg/kg of OEO were administered orally. The observed number of writhes was inhibited by 33.67, 45.88 and 55.58%, respectively. OEO produced a dose-dependent effect, with linear correlation coefficient R=0.99 (y=0.0219x+23.133), and the median effective dose found was 1226.8 mg/kg. The oral administration of 1226.8 mg/kg of OEO inhibited carrageenan-induced edema by 29.18% (p<0.05) when compared to the control group. The daily administration of OEO for six days inhibited the formation of granulomatous tissue by 36.66% (p<0.01). In ear erythema induced by croton oil, OEO presented a significant inhibition (37.9%). In the vascular permeability test, treatment with OEO decreased the response to histamine, inhibiting vascular permeability by 54.16%. In carrageenan-induced peritonitis, OEO reduced the number of neutrophils migrating compared to the control group by 80.14%. These results suggested that OEO has anti-inflammatory and antinociceptive activities, probably of peripheral origin and linked to prostaglandin biosynthesis inhibition.
format	Artigo
author	FAVACHO, Hugo Alexandre Silva
author2	OLIVEIRA, Bianca R. SANTOS, Kelem Costa dos MEDEIROS, Benedito Júnior Lima de SOUSA, Pergentino José da Cunha PERAZZO, Fabio Ferreira CARVALHO, José Carlos Tavares
author2Str	OLIVEIRA, Bianca R. SANTOS, Kelem Costa dos MEDEIROS, Benedito Júnior Lima de SOUSA, Pergentino José da Cunha PERAZZO, Fabio Ferreira CARVALHO, José Carlos Tavares
title	Anti-inflammatory and antinociceptive activities of Euterpe oleracea Mart., Arecaceae, oil
title_short	Anti-inflammatory and antinociceptive activities of Euterpe oleracea Mart., Arecaceae, oil
title_full	Anti-inflammatory and antinociceptive activities of Euterpe oleracea Mart., Arecaceae, oil
title_fullStr	Anti-inflammatory and antinociceptive activities of Euterpe oleracea Mart., Arecaceae, oil
title_full_unstemmed	Anti-inflammatory and antinociceptive activities of Euterpe oleracea Mart., Arecaceae, oil
title_sort	anti-inflammatory and antinociceptive activities of euterpe oleracea mart., arecaceae, oil
publishDate	2014
url	http://repositorio.ufpa.br/jspui/handle/2011/5952
_version_	1787149032376762368
score	11.653393

Anti-inflammatory and antinociceptive activities of Euterpe oleracea Mart., Arecaceae, oil

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