Lack of evidence for human infection with Xenotropic murine leukemia virus-related virus in the Brazilian Amazon basin
Introduction: This study confirmed the absence of natural infection with Xenotropic murine leukemia virus-related virus (XMRV) or XMRV-related disease in human populations of the Brazilian Amazon basin. We demonstrated that 803 individuals of both sexes, who were residents of Belem in the Brazilian...
| Autor principal: | GOMES, Samara Tatielle Monteiro |
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| Outros Autores: | IMBIRIBA, Luciana, BURBANO, Rommel Mario Rodriguéz, SILVA, Artur Luiz da Costa da, FEITOSA, Rosimar Neris Martins, VALLINOTO, Izaura Maria Vieira Cayres, ISHAK, Marluísa de Oliveira Guimarães, ISHAK, Ricardo, VALLINOTO, Antonio Carlos Rosário |
| Grau: | Artigo |
| Idioma: | eng |
| Publicado em: |
2014
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| Acesso em linha: |
http://repositorio.ufpa.br/jspui/handle/2011/5955 |
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ir-2011-5955 |
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ir-2011-59552024-09-18T14:20:31Z Lack of evidence for human infection with Xenotropic murine leukemia virus-related virus in the Brazilian Amazon basin GOMES, Samara Tatielle Monteiro IMBIRIBA, Luciana BURBANO, Rommel Mario Rodriguéz SILVA, Artur Luiz da Costa da FEITOSA, Rosimar Neris Martins VALLINOTO, Izaura Maria Vieira Cayres ISHAK, Marluísa de Oliveira Guimarães ISHAK, Ricardo VALLINOTO, Antonio Carlos Rosário Vírus da leucemia murina Leucemia murina Retroviridae Infecções por retroviridae Belém - PA Pará - Estado Amazônia brasileira Vírus xenotrópico Retrovírus Introduction: This study confirmed the absence of natural infection with Xenotropic murine leukemia virus-related virus (XMRV) or XMRV-related disease in human populations of the Brazilian Amazon basin. We demonstrated that 803 individuals of both sexes, who were residents of Belem in the Brazilian State of Pará, were not infected with XMRV. Methods: Individuals were divided into 4 subgroups: healthy individuals, individuals infected with human immunodeficiency virus, type 1 (HIV-1), individuals infected with human T-lymphotrophic virus, types 1 or 2 (HTLV-1/2), and individuals with prostate cancer. XMRV infection was investigated by nested PCR to detect the viral gag gene and by quantitative PCR to detect pol. Results: There was no amplification of either gag or pol segments from XRMV in any of the samples examined. Conclusions: This study supports the conclusions of the studies that eventually led to the retraction of the original study reporting the association between XMRV and human diseases. 2014-10-31T13:45:44Z 2014-10-31T13:45:44Z 2014-06 Artigo de Periódico GOMES, Samara Tatielle Monteiro et al. Lack of evidence for human infection with Xenotropic murine leukemia virus-related virus in the Brazilian Amazon basin. Revista da Sociedade Brasileira de Medicina Tropical, Uberaba, v. 47, n. 3, p. 302-306, maio/jun. 2014. Disponível em: <http://www.scielo.br/pdf/rsbmt/v47n3/0037-8682-rsbmt-47-03-302.pdf>. Acesso em: 30 jul. 2014. <http://dx.doi.org/10.1590/0037-8682-0075-2014>. 0037-8682 http://repositorio.ufpa.br/jspui/handle/2011/5955 eng Acesso Aberto application/pdf |
| institution |
Repositório Institucional - Universidade Federal do Pará |
| collection |
RI-UFPA |
| language |
eng |
| topic |
Vírus da leucemia murina Leucemia murina Retroviridae Infecções por retroviridae Belém - PA Pará - Estado Amazônia brasileira Vírus xenotrópico Retrovírus |
| spellingShingle |
Vírus da leucemia murina Leucemia murina Retroviridae Infecções por retroviridae Belém - PA Pará - Estado Amazônia brasileira Vírus xenotrópico Retrovírus GOMES, Samara Tatielle Monteiro Lack of evidence for human infection with Xenotropic murine leukemia virus-related virus in the Brazilian Amazon basin |
| topic_facet |
Vírus da leucemia murina Leucemia murina Retroviridae Infecções por retroviridae Belém - PA Pará - Estado Amazônia brasileira Vírus xenotrópico Retrovírus |
| description |
Introduction: This study confirmed the absence of natural infection with Xenotropic murine leukemia virus-related virus (XMRV) or XMRV-related disease in human populations of the Brazilian Amazon basin. We demonstrated that 803 individuals of both sexes, who were residents of Belem in the Brazilian State of Pará, were not infected with XMRV. Methods: Individuals were divided into 4 subgroups: healthy individuals, individuals infected with human immunodeficiency virus, type 1 (HIV-1), individuals infected with human T-lymphotrophic virus, types 1 or 2 (HTLV-1/2), and individuals with prostate cancer. XMRV infection was investigated by nested PCR to detect the viral gag gene and by quantitative PCR to detect pol. Results: There was no amplification of either gag or pol segments from XRMV in any of the samples examined. Conclusions: This study supports the conclusions of the studies that eventually led to the retraction of the original study reporting the association between XMRV and human diseases. |
| format |
Artigo |
| author |
GOMES, Samara Tatielle Monteiro |
| author2 |
IMBIRIBA, Luciana BURBANO, Rommel Mario Rodriguéz SILVA, Artur Luiz da Costa da FEITOSA, Rosimar Neris Martins VALLINOTO, Izaura Maria Vieira Cayres ISHAK, Marluísa de Oliveira Guimarães ISHAK, Ricardo VALLINOTO, Antonio Carlos Rosário |
| author2Str |
IMBIRIBA, Luciana BURBANO, Rommel Mario Rodriguéz SILVA, Artur Luiz da Costa da FEITOSA, Rosimar Neris Martins VALLINOTO, Izaura Maria Vieira Cayres ISHAK, Marluísa de Oliveira Guimarães ISHAK, Ricardo VALLINOTO, Antonio Carlos Rosário |
| title |
Lack of evidence for human infection with Xenotropic murine leukemia virus-related virus in the Brazilian Amazon basin |
| title_short |
Lack of evidence for human infection with Xenotropic murine leukemia virus-related virus in the Brazilian Amazon basin |
| title_full |
Lack of evidence for human infection with Xenotropic murine leukemia virus-related virus in the Brazilian Amazon basin |
| title_fullStr |
Lack of evidence for human infection with Xenotropic murine leukemia virus-related virus in the Brazilian Amazon basin |
| title_full_unstemmed |
Lack of evidence for human infection with Xenotropic murine leukemia virus-related virus in the Brazilian Amazon basin |
| title_sort |
lack of evidence for human infection with xenotropic murine leukemia virus-related virus in the brazilian amazon basin |
| publishDate |
2014 |
| url |
http://repositorio.ufpa.br/jspui/handle/2011/5955 |
| _version_ |
1832604706055127040 |
| score |
11.755432 |