Artigo

Anti-inflammatory and analgesic activities of Hypericum brasiliense (Willd) standardized extract

The anti-inflammatory and antinociceptive activities of the standardized leaves extract (HBSE) of Hypericum brasiliense (Guttiferae) were evaluated in animal models. Male Wistar rats were treated with H. brasiliense extract (50, 250 and 500 mg/kg, p.o.) in 3% Tween 80 0.9% saline solution. The treat...

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Autor principal: PERAZZO, Fabio Ferreira
Outros Autores: LIMA, Leonardo Mandalho, PADILHA, Marina de Mesquita, ROCHA, Leandro Machado, SOUSA, Pergentino José da Cunha, CARVALHO, José Carlos Tavares
Grau: Artigo
Idioma: eng
Publicado em: 2014
Assuntos:
Plantas medicinais
Hypericum brasiliense
Analgésicos
Agentes antiinflamatórios
Farmacologia
Acesso em linha: http://repositorio.ufpa.br/jspui/handle/2011/5957
id ir-2011-5957
recordtype dspace
spelling ir-2011-59572018-01-23T15:55:57Z Anti-inflammatory and analgesic activities of Hypericum brasiliense (Willd) standardized extract Atividades anti-inflamatória e analgésica de extratos padronizados de Hypericum brasiliense (Willd) PERAZZO, Fabio Ferreira LIMA, Leonardo Mandalho PADILHA, Marina de Mesquita ROCHA, Leandro Machado SOUSA, Pergentino José da Cunha CARVALHO, José Carlos Tavares Plantas medicinais Hypericum brasiliense Analgésicos Agentes antiinflamatórios Farmacologia The anti-inflammatory and antinociceptive activities of the standardized leaves extract (HBSE) of Hypericum brasiliense (Guttiferae) were evaluated in animal models. Male Wistar rats were treated with H. brasiliense extract (50, 250 and 500 mg/kg, p.o.) in 3% Tween 80 0.9% saline solution. The treatment of the edema induced by carrageenin with HBSE (500 mg/kg) showed significant inhibition when compared to the control group. At this dose, the edema decreased by 31.25% in the third hour after treatment (edema peak), but the dose of 50 mg/kg has inhibited the edema by 53.13% (p < 0.05). At the dose of 50 mg/kg, the decrease of the edema induced by dextran was similar to that caused by cyproheptadine. The decrease of the formation of granulomatous tissue (6.6%) was comparable to the control group. The HBSE inhibited the abdominal constrictions induced by acetic acid. At a dose of 50 mg/kg, the inhibition of the abdominal constrictions (46.4%) was comparable to that produced by indomethacin (42.9%). A dose of 250 mg/kg inhibited these constrictions by 70.66% when compared to control (p < 0.001). In the hot-plate test, an increase in the latency time was observed at a 50 mg/kg dose. These data suggest that HBSE has anti-inflammatory activity on acute process, developed principally by arachdonic acid derivates and analgesic effect due to its probable involvement in the Central Nervous System. As atividades antiinflamatória e antinociceptiva do extrato padronizado de Hypericum brasiliense (HBSE) (Guttiferae) foi avaliada em modelos animais. Ratos Wistar machos foram tratados com extrato de H. brasiliense (50, 250 e 500 mg/kg, v.o.) em solução 3% Tween 80 0,9% NaCl. O tratamento com HBSE (500 mg/kg) mostrou inibição significativa sobre o edema induzido por carragenina comparado ao grupo controle. Nessa dose, o edema foi reduzido em 31,25% na terceira hora (pico do edema) após o tratamento, mas na dose de 50 mg/kg, o edema apresentou redução de 53,13% (p < 0,05). Ainda com a dose de 50 mg/kg, a diminuição do edema induzido por dextrana foi similar ao controle positivo, ciproeptadina. Houve diminuição na formação do tecido granulomatoso (6,6%) comparável ao grupo controle. O HBSE também inibiu o número de contorções abdominais em 46,4%, estatisticamente igual ao controle positivo, tratado com indometacina (42,9%). Na dose de 250 mg/kg, houve inibição do número de contorções em 70,7% quando comparado ao grupo controle (p < 0,001). No teste da placa-quente, foi verificado aumento no tempo de latência com a dose de 50 mg/kg. Os resultados demonstram que o HBSE possui atividade antiinflamatória sobre processos agudos, principalmente quando sua gênese está relacionada à síntese dos derivados do ácido araquidônico, e seu efeito analgésico provavelmente envolve ação sobre o Sistema Nervoso Central. 2014-10-31T13:51:05Z 2014-10-31T13:51:05Z 2008-09 Artigo de Periódico PERAZZO, Fábio F. et al. Anti-inflammatory and analgesic activities of Hypericum brasiliense (Willd) standardized extract. Revista Brasileira de Farmacognosia, João Pessoa, v. 18, n. 3, p. 320-325, set. 2008. Disponível em: <http://www.scielo.br/pdf/rbfar/v18n3/a02v18n3.pdf>. Acesso em: 15 jul. 2014. <http://dx.doi.org/10.1590/S0102-695X2008000300002>. 0102-695X http://repositorio.ufpa.br/jspui/handle/2011/5957 eng Acesso Aberto application/pdf
institution Repositório Institucional - Universidade Federal do Pará
collection RI-UFPA
language eng
topic Plantas medicinais
Hypericum brasiliense
Analgésicos
Agentes antiinflamatórios
Farmacologia
spellingShingle Plantas medicinais
Hypericum brasiliense
Analgésicos
Agentes antiinflamatórios
Farmacologia
PERAZZO, Fabio Ferreira
Anti-inflammatory and analgesic activities of Hypericum brasiliense (Willd) standardized extract
topic_facet Plantas medicinais
Hypericum brasiliense
Analgésicos
Agentes antiinflamatórios
Farmacologia
description The anti-inflammatory and antinociceptive activities of the standardized leaves extract (HBSE) of Hypericum brasiliense (Guttiferae) were evaluated in animal models. Male Wistar rats were treated with H. brasiliense extract (50, 250 and 500 mg/kg, p.o.) in 3% Tween 80 0.9% saline solution. The treatment of the edema induced by carrageenin with HBSE (500 mg/kg) showed significant inhibition when compared to the control group. At this dose, the edema decreased by 31.25% in the third hour after treatment (edema peak), but the dose of 50 mg/kg has inhibited the edema by 53.13% (p < 0.05). At the dose of 50 mg/kg, the decrease of the edema induced by dextran was similar to that caused by cyproheptadine. The decrease of the formation of granulomatous tissue (6.6%) was comparable to the control group. The HBSE inhibited the abdominal constrictions induced by acetic acid. At a dose of 50 mg/kg, the inhibition of the abdominal constrictions (46.4%) was comparable to that produced by indomethacin (42.9%). A dose of 250 mg/kg inhibited these constrictions by 70.66% when compared to control (p < 0.001). In the hot-plate test, an increase in the latency time was observed at a 50 mg/kg dose. These data suggest that HBSE has anti-inflammatory activity on acute process, developed principally by arachdonic acid derivates and analgesic effect due to its probable involvement in the Central Nervous System.
format Artigo
author PERAZZO, Fabio Ferreira
author2 LIMA, Leonardo Mandalho
PADILHA, Marina de Mesquita
ROCHA, Leandro Machado
SOUSA, Pergentino José da Cunha
CARVALHO, José Carlos Tavares
author2Str LIMA, Leonardo Mandalho
PADILHA, Marina de Mesquita
ROCHA, Leandro Machado
SOUSA, Pergentino José da Cunha
CARVALHO, José Carlos Tavares
title Anti-inflammatory and analgesic activities of Hypericum brasiliense (Willd) standardized extract
title_short Anti-inflammatory and analgesic activities of Hypericum brasiliense (Willd) standardized extract
title_full Anti-inflammatory and analgesic activities of Hypericum brasiliense (Willd) standardized extract
title_fullStr Anti-inflammatory and analgesic activities of Hypericum brasiliense (Willd) standardized extract
title_full_unstemmed Anti-inflammatory and analgesic activities of Hypericum brasiliense (Willd) standardized extract
title_sort anti-inflammatory and analgesic activities of hypericum brasiliense (willd) standardized extract
publishDate 2014
url http://repositorio.ufpa.br/jspui/handle/2011/5957
_version_ 1787149150527160320
score 11.653393

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