Infecções pelos vírus das hepatites B e C e o carcinoma hepatocelular na Amazônia oriental
In order to contribute to a better understanding of the possible role of hepatits B and C in the etiopathogenis of HCC in the East Amazon, there were studied 36 patients in Belém/PA. Serological hepatitis markers were evaluated and polymerase chain reaction assays were used to detect HBV-DNA and HCV...
| Autor principal: | MIRANDA, Esther Castello Branco Mello |
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| Outros Autores: | MÓIA, Lizomar de Jesus Maués Pereira, AMARAL, Ivanete do Socorro Abraçado, BARBOSA, Maria Silvia de Brito, CONDE, Simone Regina Souza da Silva, ARAÚJO, Marialva Tereza Ferreira de, CRUZ, Ermelinda do Rosário Moutinho da, DEMACHKI, Samia, BENSABATH, Gilberta, SOARES, Manoel do Carmo Pereira |
| Grau: | Artigo |
| Idioma: | por |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: |
http://repositorio.ufpa.br/jspui/handle/2011/6114 |
| Resumo: |
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In order to contribute to a better understanding of the possible role of hepatits B and C in the etiopathogenis of HCC in the East Amazon, there were studied 36 patients in Belém/PA. Serological hepatitis markers were evaluated and polymerase chain reaction assays were used to detect HBV-DNA and HCV-RNA. Alcohol abuse was observed in 33.3% and cirrhosis in 83.3%. In 88.9% of the sample, one or more hepatitis B markers were positive. Also, 8.3% those patients had anti-HCV simultaneously positive. The HBsAg serological test was positive in 58.3%; anti-HBc in 86%; anti-HBe in 85.7%; anti-HBe in 9.5%; IgM anti-HBc in 57.1%. The HBV DNA was found in 37.7% and in 65% of the HBsAg positive. The HCV RNA was detected in 8.5% and in 100% of' the patients positive to anti-HCV. The AFP was above the normal value in 88.9% of patients, with levels up to 400ng/ml in 75% of them. In conclusion, hepatitis B virus infection seems to be important in the etiology of HCC and improving measures such immunization and screening in the risk population should be emphasyzed. |