Evaluation of the therapeutic response of hepatitis C in coinfected patients (HIV/HCV): a study of cases from a hospital for chronic liver diseases in the Eastern Brazilian Amazon
INTRODUCTION: The aim of this study was to evaluate the therapeutic response of hepatitis C in patients coinfected with human immunodeficiency virus (HIV-1). METHODS: A retrospective study of 20 patients coinfected with HIV-1/HCV who were treated in the outpatient liver clinic at the Sacred House of...
| Autor principal: | AMARAL, Ivanete do Socorro Abraçado |
|---|---|
| Outros Autores: | MÓIA, Lizomar de Jesus Maués Pereira, BARBOSA, Maria Silvia de Brito, DEMACHKI, Samia, ARAÚJO, Marialva Tereza Ferreira de, SOARES, Manoel do Carmo Pereira |
| Grau: | Artigo |
| Idioma: | eng |
| Publicado em: |
2014
|
| Assuntos: | |
| Acesso em linha: |
http://repositorio.ufpa.br/jspui/handle/2011/6120 |
| id |
ir-2011-6120 |
|---|---|
| recordtype |
dspace |
| spelling |
ir-2011-61202019-05-23T13:25:38Z Evaluation of the therapeutic response of hepatitis C in coinfected patients (HIV/HCV): a study of cases from a hospital for chronic liver diseases in the Eastern Brazilian Amazon AMARAL, Ivanete do Socorro Abraçado MÓIA, Lizomar de Jesus Maués Pereira BARBOSA, Maria Silvia de Brito DEMACHKI, Samia ARAÚJO, Marialva Tereza Ferreira de SOARES, Manoel do Carmo Pereira Doenças infecciosas Hepatite C Hepacivirus HIV-1 Coinfecção Tratamento Pará - Estado Amazônia brasileira INTRODUCTION: The aim of this study was to evaluate the therapeutic response of hepatitis C in patients coinfected with human immunodeficiency virus (HIV-1). METHODS: A retrospective study of 20 patients coinfected with HIV-1/HCV who were treated in the outpatient liver clinic at the Sacred House of Mercy Foundation Hospital of Pará (Fundação Santa Casa de Misericórdia do Pará - FSCMPA) from April 2004 to June 2009. Patients were treated with 180µg PEG interferon-α2a in combination with ribavirin (1,000 to 1,250mg/day) for 48 weeks. The end point was the sustained virological response (SVR) rate (HCV RNA negative 24 weeks after completing treatment). RESULTS: The mean age of the patients was 40±9.5 years, of which 89% (n=17) were male, and the HCV genotypes were genotype 1 (55%, n=11/20), genotype 2 (10%, n=2/20) and genotype 3 (35%, n=7/20). The mean CD4+ lymphocyte count was 507.8, and the liver fibrosis stages were (METAVIR) F1 (25%), F2 (55%), F3 (10%) and F4 (10%). The early virological response (EVR) was 60%, the end-of-treatment virological response (EOTVR) was 45% and the SVR was 45%. CONCLUSIONS: The median HCV viral load was high, and in 85% of cases in which highly active antiretroviral therapy (HAART) was used, none of the patients with F3-F4 fibrosis responded to treatment. Of the twenty patients treated, 45% achieved SVR and 45% achieved EOTVR. Studies that include cases from a wider region are needed to better evaluate these findings. 2014-11-27T15:30:23Z 2014-11-27T15:30:23Z 2013-02 Artigo de Periódico AMARAL, Ivanete do Socorro Abraçado et al. Evaluation of the therapeutic response of hepatitis C in coinfected patients (HIV/HCV): a study of cases from a hospital for chronic liver diseases in the Eastern Brazilian Amazon. Revista da Sociedade Brasileira de Medicina Tropical, Uberaba, v. 46, n. 1, p. 20-23, jan./fev. 2013. Disponível em: <http://www.scielo.br/pdf/rsbmt/v46n1/0037-8682-rsbmt-46-01-020.pdf>. Acesso em: 25 nov. 2014. <http://dx.doi.org/10.1590/0037-868215432013>. 0037-8682 http://repositorio.ufpa.br/jspui/handle/2011/6120 eng Acesso Aberto application/pdf |
| institution |
Repositório Institucional - Universidade Federal do Pará |
| collection |
RI-UFPA |
| language |
eng |
| topic |
Doenças infecciosas Hepatite C Hepacivirus HIV-1 Coinfecção Tratamento Pará - Estado Amazônia brasileira |
| spellingShingle |
Doenças infecciosas Hepatite C Hepacivirus HIV-1 Coinfecção Tratamento Pará - Estado Amazônia brasileira AMARAL, Ivanete do Socorro Abraçado Evaluation of the therapeutic response of hepatitis C in coinfected patients (HIV/HCV): a study of cases from a hospital for chronic liver diseases in the Eastern Brazilian Amazon |
| topic_facet |
Doenças infecciosas Hepatite C Hepacivirus HIV-1 Coinfecção Tratamento Pará - Estado Amazônia brasileira |
| description |
INTRODUCTION: The aim of this study was to evaluate the therapeutic response of hepatitis C in patients coinfected with human immunodeficiency virus (HIV-1). METHODS: A retrospective study of 20 patients coinfected with HIV-1/HCV who were treated in the outpatient liver clinic at the Sacred House of Mercy Foundation Hospital of Pará (Fundação Santa Casa de Misericórdia do Pará - FSCMPA) from April 2004 to June 2009. Patients were treated with 180µg PEG interferon-α2a in combination with ribavirin (1,000 to 1,250mg/day) for 48 weeks. The end point was the sustained virological response (SVR) rate (HCV RNA negative 24 weeks after completing treatment). RESULTS: The mean age of the patients was 40±9.5 years, of which 89% (n=17) were male, and the HCV genotypes were genotype 1 (55%, n=11/20), genotype 2 (10%, n=2/20) and genotype 3 (35%, n=7/20). The mean CD4+ lymphocyte count was 507.8, and the liver fibrosis stages were (METAVIR) F1 (25%), F2 (55%), F3 (10%) and F4 (10%). The early virological response (EVR) was 60%, the end-of-treatment virological response (EOTVR) was 45% and the SVR was 45%. CONCLUSIONS: The median HCV viral load was high, and in 85% of cases in which highly active antiretroviral therapy (HAART) was used, none of the patients with F3-F4 fibrosis responded to treatment. Of the twenty patients treated, 45% achieved SVR and 45% achieved EOTVR. Studies that include cases from a wider region are needed to better evaluate these findings. |
| format |
Artigo |
| author |
AMARAL, Ivanete do Socorro Abraçado |
| author2 |
MÓIA, Lizomar de Jesus Maués Pereira BARBOSA, Maria Silvia de Brito DEMACHKI, Samia ARAÚJO, Marialva Tereza Ferreira de SOARES, Manoel do Carmo Pereira |
| author2Str |
MÓIA, Lizomar de Jesus Maués Pereira BARBOSA, Maria Silvia de Brito DEMACHKI, Samia ARAÚJO, Marialva Tereza Ferreira de SOARES, Manoel do Carmo Pereira |
| title |
Evaluation of the therapeutic response of hepatitis C in coinfected patients (HIV/HCV): a study of cases from a hospital for chronic liver diseases in the Eastern Brazilian Amazon |
| title_short |
Evaluation of the therapeutic response of hepatitis C in coinfected patients (HIV/HCV): a study of cases from a hospital for chronic liver diseases in the Eastern Brazilian Amazon |
| title_full |
Evaluation of the therapeutic response of hepatitis C in coinfected patients (HIV/HCV): a study of cases from a hospital for chronic liver diseases in the Eastern Brazilian Amazon |
| title_fullStr |
Evaluation of the therapeutic response of hepatitis C in coinfected patients (HIV/HCV): a study of cases from a hospital for chronic liver diseases in the Eastern Brazilian Amazon |
| title_full_unstemmed |
Evaluation of the therapeutic response of hepatitis C in coinfected patients (HIV/HCV): a study of cases from a hospital for chronic liver diseases in the Eastern Brazilian Amazon |
| title_sort |
evaluation of the therapeutic response of hepatitis c in coinfected patients (hiv/hcv): a study of cases from a hospital for chronic liver diseases in the eastern brazilian amazon |
| publishDate |
2014 |
| url |
http://repositorio.ufpa.br/jspui/handle/2011/6120 |
| _version_ |
1832603436360663040 |
| score |
11.755432 |