Copaiba oil effect under different pathways in mice subjected to sepsis

BOTELHO, Nara Macedo; SILVEIRA, Edvaldo Lima; LOPES, Letícia Nobre; SANTOS, Felipe Augusto Folha; TEIXEIRA, Renan Kleber Costa; SILVA, Thaís Travassos da

Artigo

Copaiba oil effect under different pathways in mice subjected to sepsis

PURPOSE: To evaluate the effects of copaiba oil administered by different routes on survival of mices subjected to cecal ligation and puncture. METHODS: Thirty two mice were distributed into four study groups (N=8): Sham group: normal standard animals; Control group: submitted a cecal ligation and p...

ver descrição completa

Autor principal:	BOTELHO, Nara Macedo
Outros Autores:	SILVEIRA, Edvaldo Lima, LOPES, Letícia Nobre, SANTOS, Felipe Augusto Folha, TEIXEIRA, Renan Kleber Costa, SILVA, Thaís Travassos da
Grau:	Artigo
Idioma:	eng
Publicado em:	Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia 2015
Assuntos:	Plantas medicinais Óleo de copaíba Doenças peritoneais Rato como animal de laboratório Balsams Peritoneal diseases Ligation Mice
Acesso em linha:	http://repositorio.ufpa.br/jspui/handle/2011/6335 http://dx.doi.org/10.1590/S0102-86502014000800008

id	ir-2011-6335
recordtype	dspace
spelling	ir-2011-63352020-01-29T14:09:05Z Copaiba oil effect under different pathways in mice subjected to sepsis BOTELHO, Nara Macedo SILVEIRA, Edvaldo Lima LOPES, Letícia Nobre SANTOS, Felipe Augusto Folha TEIXEIRA, Renan Kleber Costa SILVA, Thaís Travassos da Plantas medicinais Óleo de copaíba Doenças peritoneais Rato como animal de laboratório Balsams Peritoneal diseases Ligation Mice PURPOSE: To evaluate the effects of copaiba oil administered by different routes on survival of mices subjected to cecal ligation and puncture. METHODS: Thirty two mice were distributed into four study groups (N=8): Sham group: normal standard animals; Control group: submitted a cecal ligation and puncture (CLP); Gavage group: submitted a CLP, and treat with copaiba oil by gavage; and Subcutaneous group: submitted a CLP, and treat with copaiba oil by subcutaneous injection. After the death of the histological analysis were performed. The Kaplan-Meier curves of surviving time were realized. RESULTS: All animals that received copaiba, regardless of the route used, survived longer when compared to the control group (p<0.0001), whereas the survival time ranged from 20 hours for the control group up to 32 hours for the animals of gavage group and 52 for subcutaneous group. The animals that received gavage copaiba lived about and about 20 hours unless the subcutaneous group (p=0.0042). There was no statistical difference when compared the intensity of inflammatory response (p>0.05). CONCLUSION: Prophylactic subcutaneous administration of copaiba in mice subjected to severe sepsis by cecal ligation and puncture, resulted in a survival time higher than non-use or use of this oil by gavage. CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico SILVEIRA, E. L. Universidade Federal do Pará 2015-02-24T15:28:27Z 2015-02-24T15:28:27Z 2014-08 Artigo de Periódico BOTELHO, Nara Macedo et al. Copaiba oil effect under different pathways in mice subjected to sepsis. Acta Cirúrgica Brasileira, São Paulo, v. 29, n. 8, p. 528-531, Aug. 2014. DOI: http://dx.doi.org/10.1590/S0102-86502014000800008. Disponível em: http://repositorio.ufpa.br/jspui/handle/2011/6335. Acesso em:. 1678-2674 http://repositorio.ufpa.br/jspui/handle/2011/6335 http://dx.doi.org/10.1590/S0102-86502014000800008 eng Acta Cirúrgica Brasileira Acesso Aberto application/pdf Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia Brasil SOBRADPEC http://ref.scielo.org/fdkky3
institution	Repositório Institucional - Universidade Federal do Pará
collection	RI-UFPA
language	eng
topic	Plantas medicinais Óleo de copaíba Doenças peritoneais Rato como animal de laboratório Balsams Peritoneal diseases Ligation Mice
spellingShingle	Plantas medicinais Óleo de copaíba Doenças peritoneais Rato como animal de laboratório Balsams Peritoneal diseases Ligation Mice BOTELHO, Nara Macedo Copaiba oil effect under different pathways in mice subjected to sepsis
topic_facet	Plantas medicinais Óleo de copaíba Doenças peritoneais Rato como animal de laboratório Balsams Peritoneal diseases Ligation Mice
description	PURPOSE: To evaluate the effects of copaiba oil administered by different routes on survival of mices subjected to cecal ligation and puncture. METHODS: Thirty two mice were distributed into four study groups (N=8): Sham group: normal standard animals; Control group: submitted a cecal ligation and puncture (CLP); Gavage group: submitted a CLP, and treat with copaiba oil by gavage; and Subcutaneous group: submitted a CLP, and treat with copaiba oil by subcutaneous injection. After the death of the histological analysis were performed. The Kaplan-Meier curves of surviving time were realized. RESULTS: All animals that received copaiba, regardless of the route used, survived longer when compared to the control group (p<0.0001), whereas the survival time ranged from 20 hours for the control group up to 32 hours for the animals of gavage group and 52 for subcutaneous group. The animals that received gavage copaiba lived about and about 20 hours unless the subcutaneous group (p=0.0042). There was no statistical difference when compared the intensity of inflammatory response (p>0.05). CONCLUSION: Prophylactic subcutaneous administration of copaiba in mice subjected to severe sepsis by cecal ligation and puncture, resulted in a survival time higher than non-use or use of this oil by gavage.
format	Artigo
author	BOTELHO, Nara Macedo
author2	SILVEIRA, Edvaldo Lima LOPES, Letícia Nobre SANTOS, Felipe Augusto Folha TEIXEIRA, Renan Kleber Costa SILVA, Thaís Travassos da
author2Str	SILVEIRA, Edvaldo Lima LOPES, Letícia Nobre SANTOS, Felipe Augusto Folha TEIXEIRA, Renan Kleber Costa SILVA, Thaís Travassos da
title	Copaiba oil effect under different pathways in mice subjected to sepsis
title_short	Copaiba oil effect under different pathways in mice subjected to sepsis
title_full	Copaiba oil effect under different pathways in mice subjected to sepsis
title_fullStr	Copaiba oil effect under different pathways in mice subjected to sepsis
title_full_unstemmed	Copaiba oil effect under different pathways in mice subjected to sepsis
title_sort	copaiba oil effect under different pathways in mice subjected to sepsis
publisher	Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
publishDate	2015
url	http://repositorio.ufpa.br/jspui/handle/2011/6335 http://dx.doi.org/10.1590/S0102-86502014000800008
_version_	1832604386512076800
score	11.755432

Copaiba oil effect under different pathways in mice subjected to sepsis

Registros relacionados