Comparison between histopathologic features of leprosy in reaction lesions in HIV coinfected and non-coinfected patients

PIRES, Carla Andréa Avelar; MIRANDA, Mario Fernando Ribeiro de; BITTENCOURT, Maraya de Jesus Semblano; BRITO, Arival Cardoso de; XAVIER, Marília Brasil

Artigo

Comparison between histopathologic features of leprosy in reaction lesions in HIV coinfected and non-coinfected patients

BACKGROUND: Leprosy and HIV are diseases that have a major impact on public health in Brazil. Patients coinfected with both diseases, appear to be at higher risk to develop leprosy reactions. OBJECTIVE: The aim of this study is to describe the histopathological aspects of cutaneous lesions during re...

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Autor principal:	PIRES, Carla Andréa Avelar
Outros Autores:	MIRANDA, Mario Fernando Ribeiro de, BITTENCOURT, Maraya de Jesus Semblano, BRITO, Arival Cardoso de, XAVIER, Marília Brasil
Grau:	Artigo
Idioma:	eng
Publicado em:	2015
Assuntos:	Histologia Hanseníase HIV (Vírus) Coinfecção Brasil - País Doenças infecciosas
Acesso em linha:	http://repositorio.ufpa.br/jspui/handle/2011/6517

id	ir-2011-6517
recordtype	dspace
spelling	ir-2011-65172017-12-14T13:26:23Z Comparison between histopathologic features of leprosy in reaction lesions in HIV coinfected and non-coinfected patients PIRES, Carla Andréa Avelar MIRANDA, Mario Fernando Ribeiro de BITTENCOURT, Maraya de Jesus Semblano BRITO, Arival Cardoso de XAVIER, Marília Brasil Histologia Hanseníase HIV (Vírus) Coinfecção Brasil - País Doenças infecciosas BACKGROUND: Leprosy and HIV are diseases that have a major impact on public health in Brazil. Patients coinfected with both diseases, appear to be at higher risk to develop leprosy reactions. OBJECTIVE: The aim of this study is to describe the histopathological aspects of cutaneous lesions during reactional states in a group of patients with HIV-leprosy coinfection, compared to patients with leprosy, without coinfection. METHODS: Two groups were established: group 1 comprised of 40 patients coinfected with HIV-leprosy; group 2, comprised of 107 patients with leprosy only. Patients presenting reactional states of leprosy had their lesions biopsied and comparatively evaluated. RESULTS: Reversal reaction was the most frequent feature in both groups, with dermis edema as the most common histopathological finding. Giant cells were seen in all group 1 histopathological examinations. Dermis edema was the most common finding in patients with erythema nodosum leprosum. CONCLUSION: Few histopathological differences were found in both groups, with reversal reaction as the most significant one, although this fact should be analyzed considering the predominant BT clinical form in the coinfected group and BB form in the group without HIV. Larger prospective studies in patients with HIV-leprosy coinfection are needed to confirm and broaden these results. 2015-04-01T14:32:22Z 2015-04-01T14:32:22Z 2015-02 Artigo de Periódico PIRES, Carla Andréa Avelar et al. Comparison between histopathologic features of leprosy in reaction lesions in HIV coinfected and non-coinfected patients. Anais Brasileiros de Dermatologia, Rio de Janeiro, v. 90, n. 1, p. 27-34, jan./fev. 2015. Disponível em: <http://www.scielo.br/pdf/abd/v90n1/0365-0596-abd-90-01-0027.pdf>. Acesso em: 31 mar. 2015. <http://dx.doi.org/10.1590/abd1806-4841.20153048>. 1806-4841 http://repositorio.ufpa.br/jspui/handle/2011/6517 eng Acesso Aberto application/pdf
institution	Repositório Institucional - Universidade Federal do Pará
collection	RI-UFPA
language	eng
topic	Histologia Hanseníase HIV (Vírus) Coinfecção Brasil - País Doenças infecciosas
spellingShingle	Histologia Hanseníase HIV (Vírus) Coinfecção Brasil - País Doenças infecciosas PIRES, Carla Andréa Avelar Comparison between histopathologic features of leprosy in reaction lesions in HIV coinfected and non-coinfected patients
topic_facet	Histologia Hanseníase HIV (Vírus) Coinfecção Brasil - País Doenças infecciosas
description	BACKGROUND: Leprosy and HIV are diseases that have a major impact on public health in Brazil. Patients coinfected with both diseases, appear to be at higher risk to develop leprosy reactions. OBJECTIVE: The aim of this study is to describe the histopathological aspects of cutaneous lesions during reactional states in a group of patients with HIV-leprosy coinfection, compared to patients with leprosy, without coinfection. METHODS: Two groups were established: group 1 comprised of 40 patients coinfected with HIV-leprosy; group 2, comprised of 107 patients with leprosy only. Patients presenting reactional states of leprosy had their lesions biopsied and comparatively evaluated. RESULTS: Reversal reaction was the most frequent feature in both groups, with dermis edema as the most common histopathological finding. Giant cells were seen in all group 1 histopathological examinations. Dermis edema was the most common finding in patients with erythema nodosum leprosum. CONCLUSION: Few histopathological differences were found in both groups, with reversal reaction as the most significant one, although this fact should be analyzed considering the predominant BT clinical form in the coinfected group and BB form in the group without HIV. Larger prospective studies in patients with HIV-leprosy coinfection are needed to confirm and broaden these results.
format	Artigo
author	PIRES, Carla Andréa Avelar
author2	MIRANDA, Mario Fernando Ribeiro de BITTENCOURT, Maraya de Jesus Semblano BRITO, Arival Cardoso de XAVIER, Marília Brasil
author2Str	MIRANDA, Mario Fernando Ribeiro de BITTENCOURT, Maraya de Jesus Semblano BRITO, Arival Cardoso de XAVIER, Marília Brasil
title	Comparison between histopathologic features of leprosy in reaction lesions in HIV coinfected and non-coinfected patients
title_short	Comparison between histopathologic features of leprosy in reaction lesions in HIV coinfected and non-coinfected patients
title_full	Comparison between histopathologic features of leprosy in reaction lesions in HIV coinfected and non-coinfected patients
title_fullStr	Comparison between histopathologic features of leprosy in reaction lesions in HIV coinfected and non-coinfected patients
title_full_unstemmed	Comparison between histopathologic features of leprosy in reaction lesions in HIV coinfected and non-coinfected patients
title_sort	comparison between histopathologic features of leprosy in reaction lesions in hiv coinfected and non-coinfected patients
publishDate	2015
url	http://repositorio.ufpa.br/jspui/handle/2011/6517
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score	11.755432

Comparison between histopathologic features of leprosy in reaction lesions in HIV coinfected and non-coinfected patients

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