Detection of Helicobacter pylori in gastric cancer
Background and Objectives — Considering the high prevalence of stomach cancer in the northern region of Brazil and the recognized relationship between chronic gastric inflammation caused by Helicobacter pylori, and its carcinogenic potential, the objective we had with this study was to investigate t...
| Autor principal: | PEREIRA, Luana Paredes Leite de Barros |
|---|---|
| Outros Autores: | WAISBERG, Jaques, ANDRÉ, Eduardo Antonio, ZANOTO, Arnaldo, MENDES JÚNIOR, João Paulo, SOARES, Heloísa Prado |
| Grau: | Artigo |
| Idioma: | eng |
| Publicado em: |
2015
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| Acesso em linha: |
http://repositorio.ufpa.br/jspui/handle/2011/6551 |
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ir-2011-6551 |
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ir-2011-65512019-05-23T13:25:51Z Detection of Helicobacter pylori in gastric cancer PEREIRA, Luana Paredes Leite de Barros WAISBERG, Jaques ANDRÉ, Eduardo Antonio ZANOTO, Arnaldo MENDES JÚNIOR, João Paulo SOARES, Heloísa Prado Neoplasias Neoplasias gástricas Helicobacter pylori Gastrite atrófica Adenocarcinoma gástrico Etiologia Região Metropolitana de Belém Pará - Estado Amazônia brasileira Background and Objectives — Considering the high prevalence of stomach cancer in the northern region of Brazil and the recognized relationship between chronic gastric inflammation caused by Helicobacter pylori, and its carcinogenic potential, the objective we had with this study was to investigate the presence of the microorganism in macro and microscopic presentations of neoplasm in different regions of the stomach, and in non-malignant lesions concomitant to the adenocarcinoma in patients originating from the metropolitan area of Belém (State of Pará, Brazil). Methods - Examinations were made on 172 patients divided into two groups: group I, formed by 75 patients with gastric carcinoma, and group II, formed by 97 patients with mild enanthematic gastritis, considered control group. The diagnosis was obtained during endoscopic examination and the respective biopsy. Gastric neoplasms were classified macroscopically in accordance with Borrmann's classification, and microscopically in accordance with Laurén's classification. In group I, 54 patients were male and 21 female while in group II, 22 patients were male and 75 female. The average age in group I was 61.2 years (range 27 to 86 years), while in group II it was 37.5 years (range 16 to 69 years). Thin sections were prepared and stained using the hematoxylin-eosin method. In the Helicobacter pylori research, the modified Gram stain was utilized. Statistical analysis was done by utilizing the chi-squared (c 2) test, Mann-Whitney test (U), and Fisher's exact test. Results - The results showed the detection of Helicobacter pylori were significantly greater in patients with mild enanthematic gastritis than in patients with gastric carcinoma. The presence of Helicobacter pylori in patients with gastric carcinoma and mild enanthematic gastritis was significantly greater in the antral region than in other gastric regions. Helicobacter pylori detection in patients with gastric carcinoma did not present a significant difference in relation to the macroscopic aspect of the tumor either intestinal or diffuse histological types. Conclusions - These data suggest the presence of the bacteria is predominant in the antral region and it does not show relation with the macroscopic types or histological intestinal or diffuse types of gastric carcinoma. 2015-04-17T16:11:19Z 2015-04-17T16:11:19Z 2001-10 Artigo de Periódico PEREIRA, Luana Paredes Leite de Barros et al. Detection of Helicobacter pylori in gastric cancer. Arquivos de Gastroenterologia, São Paulo, v. 38, n. 4, p. 240-246, out. 2001. Disponível em: <http://www.scielo.br/pdf/ag/v38n4/14261.pdf>. Acesso em: 16 abr. 2015. <http://dx.doi.org/10.1590/S0004-28032001000400006>. 0004-2803 http://repositorio.ufpa.br/jspui/handle/2011/6551 eng Acesso Aberto application/pdf |
| institution |
Repositório Institucional - Universidade Federal do Pará |
| collection |
RI-UFPA |
| language |
eng |
| topic |
Neoplasias Neoplasias gástricas Helicobacter pylori Gastrite atrófica Adenocarcinoma gástrico Etiologia Região Metropolitana de Belém Pará - Estado Amazônia brasileira |
| spellingShingle |
Neoplasias Neoplasias gástricas Helicobacter pylori Gastrite atrófica Adenocarcinoma gástrico Etiologia Região Metropolitana de Belém Pará - Estado Amazônia brasileira PEREIRA, Luana Paredes Leite de Barros Detection of Helicobacter pylori in gastric cancer |
| topic_facet |
Neoplasias Neoplasias gástricas Helicobacter pylori Gastrite atrófica Adenocarcinoma gástrico Etiologia Região Metropolitana de Belém Pará - Estado Amazônia brasileira |
| description |
Background and Objectives — Considering the high prevalence of stomach cancer in the northern region of Brazil and the recognized relationship between chronic gastric inflammation caused by Helicobacter pylori, and its carcinogenic potential, the objective we had with this study was to investigate the presence of the microorganism in macro and microscopic presentations of neoplasm in different regions of the stomach, and in non-malignant lesions concomitant to the adenocarcinoma in patients originating from the metropolitan area of Belém (State of Pará, Brazil). Methods - Examinations were made on 172 patients divided into two groups: group I, formed by 75 patients with gastric carcinoma, and group II, formed by 97 patients with mild enanthematic gastritis, considered control group. The diagnosis was obtained during endoscopic examination and the respective biopsy. Gastric neoplasms were classified macroscopically in accordance with Borrmann's classification, and microscopically in accordance with Laurén's classification. In group I, 54 patients were male and 21 female while in group II, 22 patients were male and 75 female. The average age in group I was 61.2 years (range 27 to 86 years), while in group II it was 37.5 years (range 16 to 69 years). Thin sections were prepared and stained using the hematoxylin-eosin method. In the Helicobacter pylori research, the modified Gram stain was utilized. Statistical analysis was done by utilizing the chi-squared (c 2) test, Mann-Whitney test (U), and Fisher's exact test. Results - The results showed the detection of Helicobacter pylori were significantly greater in patients with mild enanthematic gastritis than in patients with gastric carcinoma. The presence of Helicobacter pylori in patients with gastric carcinoma and mild enanthematic gastritis was significantly greater in the antral region than in other gastric regions. Helicobacter pylori detection in patients with gastric carcinoma did not present a significant difference in relation to the macroscopic aspect of the tumor either intestinal or diffuse histological types. Conclusions - These data suggest the presence of the bacteria is predominant in the antral region and it does not show relation with the macroscopic types or histological intestinal or diffuse types of gastric carcinoma. |
| format |
Artigo |
| author |
PEREIRA, Luana Paredes Leite de Barros |
| author2 |
WAISBERG, Jaques ANDRÉ, Eduardo Antonio ZANOTO, Arnaldo MENDES JÚNIOR, João Paulo SOARES, Heloísa Prado |
| author2Str |
WAISBERG, Jaques ANDRÉ, Eduardo Antonio ZANOTO, Arnaldo MENDES JÚNIOR, João Paulo SOARES, Heloísa Prado |
| title |
Detection of Helicobacter pylori in gastric cancer |
| title_short |
Detection of Helicobacter pylori in gastric cancer |
| title_full |
Detection of Helicobacter pylori in gastric cancer |
| title_fullStr |
Detection of Helicobacter pylori in gastric cancer |
| title_full_unstemmed |
Detection of Helicobacter pylori in gastric cancer |
| title_sort |
detection of helicobacter pylori in gastric cancer |
| publishDate |
2015 |
| url |
http://repositorio.ufpa.br/jspui/handle/2011/6551 |
| _version_ |
1832603517382033408 |
| score |
11.755432 |