Vitamina D e nefropatia em pacientes com diabetes Mellitus tipo 1
Diabetes Mellitus type 1 (DM1) results from destruction of the pancreatic beta cells by an immunological process, which may progress to kidney complications. Both genetic and environmental factors are involved in the pathogenesis of type 1 diabetes, and vitamin D deficiency appears as a candidate am...
| Autor principal: | LUZ, Rafael Mendonça |
|---|---|
| Grau: | Dissertação |
| Idioma: | por |
| Publicado em: |
Universidade Federal do Pará
2017
|
| Assuntos: | |
| Acesso em linha: |
http://repositorio.ufpa.br/jspui/handle/2011/7254 |
| id |
ir-2011-7254 |
|---|---|
| recordtype |
dspace |
| spelling |
ir-2011-72542017-12-20T13:39:43Z Vitamina D e nefropatia em pacientes com diabetes Mellitus tipo 1 LUZ, Rafael Mendonça FELÍCIO, João Soares http://lattes.cnpq.br/8482132737976863 YAMADA, Elizabeth Sumi http://lattes.cnpq.br/7240314827308306 Diabetes Vitamina D Mellitus Nefropatia diabética Albuminúria CNPQ::CIENCIAS DA SAUDE::MEDICINA::CLINICA MEDICA Diabetes Mellitus type 1 (DM1) results from destruction of the pancreatic beta cells by an immunological process, which may progress to kidney complications. Both genetic and environmental factors are involved in the pathogenesis of type 1 diabetes, and vitamin D deficiency appears as a candidate among the risk factors for developing both diabetes and diabetic nephropathy. The objective of this study was to evaluate the existence of an association between low levels of vitamin D with the presence and degree of diabetic nephropathy in patients with type 1 diabetes. Additionally, our study aimed to establish the prevalence of vitamin D deficiency in normal individuals of our region and determine if it differs from DM1 patients. A cross-sectional study, between November 2013 and December 2014, in which levels of 25 (OH) D and albuminuria were analyzed in 37 patients with DM1, normal creatinine levels and 36 control subjects. The patients with DM1 and hypovitaminosis D had higher levels of albuminuria compared with those with normal vitamin D levels (albuminuria = log10 1.92 vs. 1.44; p <0.05). When the group of patients was separeted according to the stage of diabetic nephropathy in those with normoalbuminuria, microalbuminuria, and macroalbuminuria, we found lower levels of 25(OH)D in the latter when compared to the first two groups (26.7 ± 6.2, 24.8 and 15.9 ± 7 ± 7.6 ng / mL; p <0.05, respectively). In DM1 group, we found correlations between vitamin D levels with the levels of albuminuria and diabetic nephropathy stages (r= -0.5, p<0.01 r= -0.4; p <0.05, respectively). Additionally, the prevalence of vitamin D deficiency among control subjects was quite high (78%), and there was no difference compared to patients with DM1, whose prevalence was 73%. Patients with type 1 diabetes when compared to control group also showed no difference regarding the average levels of 25(OH)D (24.2 ± 7.4 versus 25.8 ± 11.2 ng / mL, NS). Our data suggest an association between reduced levels of vitamin D and the presence and severity of diabetic nephropathy. In addition, patients with type 1 diabetes mellitus, when compared to normal control subjects in our region did not differ in average and status of 25(OH)D levels. O Diabetes Mellitus tipo 1 (DM1) resulta da destruição das células beta pancreáticas por um processo imunológico, podendo evoluir com complicações renais. Tanto fatores genéticos como ambientais estão envolvidos na patogenia do DM1, e a deficiência de vitamina D surge como uma candidata dentre os fatores de risco para desenvolvimento tanto do diabetes, quanto da nefropatia diabética. O objetivo deste estudo foi avaliar a existência de uma associação entre níveis reduzidos de vitamina D, com a presença e o grau de nefropatia diabética em pacientes com DM1. Adicionalmente, nosso estudo visou estabelecer a prevalência de hipovitaminose D em controles da nossa região, e determinar se esta difere dos pacientes com DM1. Realizou-se um estudo transversal, entre novembro de 2013 e dezembro de 2014, no qual foram analisados os níveis de 25-hidroxivitama D ou calcidiol [25(OH)D] e albuminúria em 37 pacientes com DM1 e níveis de creatinina normais, e em 36 indivíduos controles. Os pacientes com DM1 e hipovitaminose D apresentaram níveis de albuminúria mais elevados quando comparados com aqueles com níveis normais de vitamina D (log10 albuminúria = 1,92 versus 1,44; p < 0,05). Quando separamos o grupo com DM1 de acordo com o estágio da nefropatia diabética em pacientes com normoalbuminúria, microalbuminúria e macroalbuminúria, encontramos níveis menores de 25(OH)D nos últimos, quando comparados aos dois primeiros (26,7 ± 6,2; 24,8 ± 7 e 15,9 ± 7,6 ng/mL; p < 0,05, respectivamente). Ainda no grupo com DM1, encontramos correlações entre os níveis de vitamina D com os níveis de albuminúria e com os estágios de nefropatia diabética (r = -0,5; p < 0,01 e r = -0,4; p < 0,05, respectivamente). Adicionalmente, a prevalência de hipovitaminose D entre os indivíduos controles foi bastante elevada (78%), e não houve diferença em relação aos pacientes com DM1, cuja prevalência foi de 73%. Os pacientes com DM1, quando comparados ao grupo controle, também não apresentaram diferença entre os níveis médios de 25(OH)D (24,2 ± 7,4 versus 25,8 ± 11,2 ng/mL, NS). Nossos dados sugerem uma associação entre níveis reduzidos de vitamina D e a presença e gravidade da nefropatia diabética. Adicionalmente, os pacientes com diabetes mellitus tipo 1, quando comparados aos indivíduos controles normais em nossa região, não diferiram nos níveis médios e no status dos níveis de 25(OH)D. 2017-01-10T11:53:22Z 2017-01-10T11:53:22Z 2015-10-06 Dissertação LUZ, Rafael Mendonça. Vitamina D e nefropatia em pacientes com diabetes Mellitus tipo 1. 2015. 55 f. Dissertação (Mestrado) - Universidade Federal do Pará, Núcleo de Pesquisas em Oncologia, Belém, 2015. Programa de Pós-Graduação em Oncologia e Ciências Médicas. http://repositorio.ufpa.br/jspui/handle/2011/7254 por Acesso Aberto application/pdf Universidade Federal do Pará Brasil Núcleo de Pesquisas em Oncologia UFPA Programa de Pós-Graduação em Oncologia e Ciências Médicas |
| institution |
Repositório Institucional - Universidade Federal do Pará |
| collection |
RI-UFPA |
| language |
por |
| topic |
Diabetes Vitamina D Mellitus Nefropatia diabética Albuminúria CNPQ::CIENCIAS DA SAUDE::MEDICINA::CLINICA MEDICA |
| spellingShingle |
Diabetes Vitamina D Mellitus Nefropatia diabética Albuminúria CNPQ::CIENCIAS DA SAUDE::MEDICINA::CLINICA MEDICA LUZ, Rafael Mendonça Vitamina D e nefropatia em pacientes com diabetes Mellitus tipo 1 |
| topic_facet |
Diabetes Vitamina D Mellitus Nefropatia diabética Albuminúria CNPQ::CIENCIAS DA SAUDE::MEDICINA::CLINICA MEDICA |
| description |
Diabetes Mellitus type 1 (DM1) results from destruction of the pancreatic beta cells by an immunological process, which may progress to kidney complications. Both genetic and environmental factors are involved in the pathogenesis of type 1 diabetes, and vitamin D deficiency appears as a candidate among the risk factors for developing both diabetes and diabetic nephropathy. The objective of this study was to evaluate the existence of an association between low levels of vitamin D with the presence and degree of diabetic nephropathy in patients with type 1 diabetes. Additionally, our study aimed to establish the prevalence of vitamin D deficiency in normal individuals of our region and determine if it differs from DM1 patients. A cross-sectional study, between November 2013 and December 2014, in which levels of 25 (OH) D and albuminuria were analyzed in 37 patients with DM1, normal creatinine levels and 36 control subjects. The patients with DM1 and hypovitaminosis D had higher levels of albuminuria compared with those with normal vitamin D levels (albuminuria = log10 1.92 vs. 1.44; p <0.05). When the group of patients was separeted according to the stage of diabetic nephropathy in those with normoalbuminuria, microalbuminuria, and macroalbuminuria, we found lower levels of 25(OH)D in the latter when compared to the first two groups (26.7 ± 6.2, 24.8 and 15.9 ± 7 ± 7.6 ng / mL; p <0.05, respectively). In DM1 group, we found correlations between vitamin D levels with the levels of albuminuria and diabetic nephropathy stages (r= -0.5, p<0.01 r= -0.4; p <0.05, respectively). Additionally, the prevalence of vitamin D deficiency among control subjects was quite high (78%), and there was no difference compared to patients with DM1, whose prevalence was 73%. Patients with type 1 diabetes when compared to control group also showed no difference regarding the average levels of 25(OH)D (24.2 ± 7.4 versus 25.8 ± 11.2 ng / mL, NS). Our data suggest an association between reduced levels of vitamin D and the presence and severity of diabetic nephropathy. In addition, patients with type 1 diabetes mellitus, when compared to normal control subjects in our region did not differ in average and status of 25(OH)D levels. |
| author_additional |
FELÍCIO, João Soares |
| author_additionalStr |
FELÍCIO, João Soares |
| format |
Dissertação |
| author |
LUZ, Rafael Mendonça |
| title |
Vitamina D e nefropatia em pacientes com diabetes Mellitus tipo 1 |
| title_short |
Vitamina D e nefropatia em pacientes com diabetes Mellitus tipo 1 |
| title_full |
Vitamina D e nefropatia em pacientes com diabetes Mellitus tipo 1 |
| title_fullStr |
Vitamina D e nefropatia em pacientes com diabetes Mellitus tipo 1 |
| title_full_unstemmed |
Vitamina D e nefropatia em pacientes com diabetes Mellitus tipo 1 |
| title_sort |
vitamina d e nefropatia em pacientes com diabetes mellitus tipo 1 |
| publisher |
Universidade Federal do Pará |
| publishDate |
2017 |
| url |
http://repositorio.ufpa.br/jspui/handle/2011/7254 |
| _version_ |
1787147688193556480 |
| score |
11.653393 |