Artigo

Severe visceral leishmaniasis in children: the relationship between cytokine patterns and clinical features

Introduction: The relationship between severe clinical manifestations of visceral leishmaniasis (VL) and immune response profi les has not yet been clarifi ed, despite numerous studies on the subject. This study aimed to investigate the relationship between cytokine profi les and the presence of imm...

ver descrição completa

Autor principal: GAMA, Mônica Elinor Alves
Outros Autores: GOMES, Claudia Maria de Castro, SILVEIRA, Fernando Tobias, AURENTI, Márcia Dalastra, GONÇALVES, Eloisa da Graça do Rosario, SILVA, Antônio Rafael da, CORBETT, Carlos Eduardo Pereira
Grau: Artigo
Idioma: por
Publicado em: Universidade Federal do Pará 2017
Assuntos:
Leishmaniose visceral
Crianças
Citocinas
Pediatria
Hospitalização infantil
Acesso em linha: http://repositorio.ufpa.br/jspui/handle/2011/7722
id ir-2011-7722
recordtype dspace
spelling ir-2011-77222017-10-16T12:27:22Z Severe visceral leishmaniasis in children: the relationship between cytokine patterns and clinical features GAMA, Mônica Elinor Alves GOMES, Claudia Maria de Castro SILVEIRA, Fernando Tobias AURENTI, Márcia Dalastra GONÇALVES, Eloisa da Graça do Rosario SILVA, Antônio Rafael da CORBETT, Carlos Eduardo Pereira Leishmaniose visceral Crianças Citocinas Pediatria Hospitalização infantil Introduction: The relationship between severe clinical manifestations of visceral leishmaniasis (VL) and immune response profi les has not yet been clarifi ed, despite numerous studies on the subject. This study aimed to investigate the relationship between cytokine profi les and the presence of immunological markers associated with clinical manifestations and, particularly, signs of severity, as defi ned in a protocol drafted by the Ministry of Health (Brazil). Methods: We conducted a prospective, descriptive study between May 2008 and December 2009. This study was based on an assessment of all pediatric patients with VL who were observed in a reference hospital in Maranhão. Results: Among 27 children, 55.5% presented with more than one sign of severity or warning sign. Patients without signs of severity or warning signs and patients with only one warning sign had the highest interferon-gamma (IFN-γ) levels, although their interleukin 10 (IL-10) levels were also elevated. In contrast, patients with the features of severe disease had the lowest IFN-γ levels. Three patients who presented with more than two signs of severe disease died; these patients had undetectable interleukin 2 (IL-2) and IFN-γ levels and low IL-10 levels, which varied between 0 and 36.8pg/mL. Conclusions: Our results showed that disease severity was associated with low IFN-γ levels and elevated IL-10 levels. However, further studies with larger samples are needed to better characterize the relationship between disease severity and cytokine levels, with the aim of identifying immunological markers of active-disease severity. 2017-02-17T14:44:51Z 2017-02-17T14:44:51Z 2013-12 Artigo de Periódico GAMA, Monica Elinor Alves et al. Severe visceral leishmaniasis in children: the relationship between cytokine patterns and clinical features. Revista da Sociedade Brasileira de Medicina Tropical, Uberaba, v. 46, n. 6, p. 741-745, dez. 2013. Disponível em: <http://www.scielo.br/pdf/rsbmt/v46n6/0037-8682-rsbmt-46-06-741.pdf>. Acesso em: 17 fev. 2017. <http://dx.doi.org/10.1590/0037-8682-0203-2013>. 0037-8682 http://repositorio.ufpa.br/jspui/handle/2011/7722 por Revista da Sociedade Brasileira de Medicina Tropical Acesso Aberto application/pdf Universidade Federal do Pará Brasil UFPA
institution Repositório Institucional - Universidade Federal do Pará
collection RI-UFPA
language por
topic Leishmaniose visceral
Crianças
Citocinas
Pediatria
Hospitalização infantil
spellingShingle Leishmaniose visceral
Crianças
Citocinas
Pediatria
Hospitalização infantil
GAMA, Mônica Elinor Alves
Severe visceral leishmaniasis in children: the relationship between cytokine patterns and clinical features
topic_facet Leishmaniose visceral
Crianças
Citocinas
Pediatria
Hospitalização infantil
description Introduction: The relationship between severe clinical manifestations of visceral leishmaniasis (VL) and immune response profi les has not yet been clarifi ed, despite numerous studies on the subject. This study aimed to investigate the relationship between cytokine profi les and the presence of immunological markers associated with clinical manifestations and, particularly, signs of severity, as defi ned in a protocol drafted by the Ministry of Health (Brazil). Methods: We conducted a prospective, descriptive study between May 2008 and December 2009. This study was based on an assessment of all pediatric patients with VL who were observed in a reference hospital in Maranhão. Results: Among 27 children, 55.5% presented with more than one sign of severity or warning sign. Patients without signs of severity or warning signs and patients with only one warning sign had the highest interferon-gamma (IFN-γ) levels, although their interleukin 10 (IL-10) levels were also elevated. In contrast, patients with the features of severe disease had the lowest IFN-γ levels. Three patients who presented with more than two signs of severe disease died; these patients had undetectable interleukin 2 (IL-2) and IFN-γ levels and low IL-10 levels, which varied between 0 and 36.8pg/mL. Conclusions: Our results showed that disease severity was associated with low IFN-γ levels and elevated IL-10 levels. However, further studies with larger samples are needed to better characterize the relationship between disease severity and cytokine levels, with the aim of identifying immunological markers of active-disease severity.
format Artigo
author GAMA, Mônica Elinor Alves
author2 GOMES, Claudia Maria de Castro
SILVEIRA, Fernando Tobias
AURENTI, Márcia Dalastra
GONÇALVES, Eloisa da Graça do Rosario
SILVA, Antônio Rafael da
CORBETT, Carlos Eduardo Pereira
author2Str GOMES, Claudia Maria de Castro
SILVEIRA, Fernando Tobias
AURENTI, Márcia Dalastra
GONÇALVES, Eloisa da Graça do Rosario
SILVA, Antônio Rafael da
CORBETT, Carlos Eduardo Pereira
title Severe visceral leishmaniasis in children: the relationship between cytokine patterns and clinical features
title_short Severe visceral leishmaniasis in children: the relationship between cytokine patterns and clinical features
title_full Severe visceral leishmaniasis in children: the relationship between cytokine patterns and clinical features
title_fullStr Severe visceral leishmaniasis in children: the relationship between cytokine patterns and clinical features
title_full_unstemmed Severe visceral leishmaniasis in children: the relationship between cytokine patterns and clinical features
title_sort severe visceral leishmaniasis in children: the relationship between cytokine patterns and clinical features
publisher Universidade Federal do Pará
publishDate 2017
url http://repositorio.ufpa.br/jspui/handle/2011/7722
_version_ 1832603676001173504
score 11.755432

Registros relacionados