Aspectos clínico-patológicos do envenenamento experimental por Caudisona durissa em equinos
The clinic-pathological picture and laboratory findings in horses experimentally inoculated with the venom of Caudisona durissa terrificus (Crotalus durissus terrificus, according to the former nomenclature) are described. The purpose of this study was to contribute to the understanding of this type...
| Autor principal: | LOPES, Cinthia Távora de Albuquerque |
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| Grau: | Dissertação |
| Idioma: | por |
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Universidade Federal do Pará
2017
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http://repositorio.ufpa.br/jspui/handle/2011/8416 |
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ir-2011-8416 |
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ir-2011-84162018-04-24T12:32:49Z Aspectos clínico-patológicos do envenenamento experimental por Caudisona durissa em equinos LOPES, Cinthia Távora de Albuquerque BARBOSA NETO, José Diomedes http://lattes.cnpq.br/1516707357889557 Equino Envenenamento Crotalus durissus terrificus Caudisona durissa terrificus Cobra venenosa Veneno Ofídismo CNPQ::CIENCIAS AGRARIAS::MEDICINA VETERINARIA::MEDICINA VETERINARIA PREVENTIVA::SAUDE ANIMAL (PROGRAMAS SANITARIOS) The clinic-pathological picture and laboratory findings in horses experimentally inoculated with the venom of Caudisona durissa terrificus (Crotalus durissus terrificus, according to the former nomenclature) are described. The purpose of this study was to contribute to the understanding of this type of snake accident in horses. The lyophilized venom was diluted into 1ml of a 0.9% saline solution and was inoculated subcutaneously into five horses, at the doses of 0.12mg/kg (one horse), 0.066mg/kg (two horses) and 0.03mg/kg (two horses). The venom caused death of the horse that had received 0.12mg/kg, and of one horse of the two that had received the dose of 0.066mg/kg. The clinical course varied from 27h27min to 52h29min. The second horse inoculated with 0.066mg/kg recovered within 12 days after inoculation. The dose of 0.03mg/kg had a course of 6 to 10 days but did not cause fatal envenomation. The clinical picture in the horses was characterized by swelling of the inoculation site and adjacent areas, by apathy and lowered head, locomotory alterations shown by dragging of the hoves on the ground, decubitus and difficulty to get up, reduction of auricular, palatal, upperlip and threat reflexes, and increase of heart and breathing frequency. The laboratory examination revealed leukocytosis and lymphocytosis in two horses. There was increase of the creatine-kinase (CK), lactic dehydrogenase (DHL) and ureia; reduction in the seric levels of calcium, phosphorus and magnesium. The time of activated partial tromboplastina (TTPA) increased in the horses that died. Post mortem findings were edema of the subcutaneous tissue at the inoculated shoulder, suffusions in the epicard of left and right heart ventricles, bladder replete with urine containing a white-yellowish sediment, and hemorrhagic areas in its mucosa. Histopatologic examination revealed the liver parenchyma with diffuse moderate vacuolation affecting predominantly the intermediate area of the hepatic lobe, and slight dilation of the sinusoides in some areas; in the kidney slight dilation of the uriniferous tubules mainly in the cortex. CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico Descrevem-se os quadros clínico-patológicos e laboratoriais de equinos inoculados experimentalmente com a peçonha de Caudisona durissa terrificus (Crotalus durissus terrificus na antiga nomenclatura), com a finalidade de fornecer subsídios que favoreçam a compreensão desse tipo de acidente ofídico em equinos. O veneno liofilizado foi diluído em 1ml de solução salina a 0,9% e inoculado por via subcutânea em cinco equinos, na dose de 0,12 mg/kg (um animal), 0,066 mg/kg (dois animais) e 0,03 mg/kg (dois animais). O veneno causou a morte do equino que recebeu a dose de 0,12mg/kg e de um dos dois que receberam a dose de 0,066mg/kg, com evolução de 27h27min e 52h29min, respectivamente. O segundo animal que recebeu a dose de 0,066mg/kg também adoeceu, mas recuperou-se após 12 dias da inoculação. A dose de 0,03 mg/kg determinou quadros não fatais do envenenamento, com período de evolução que variou entre 6 e 10 dias. O quadro clínico caracterizou-se por considerável aumento de volume no local de inoculação (omoplata) que se estendeu por todo o membro, apatia, cabeça baixa, alterações locomotoras evidenciadas pelo arrastar das pinças no solo, decúbito e dificuldade para levantar, redução dos reflexos auricular, palatal, do lábio superior e de ameaça, aumento das frequências cardíaca e respiratória. Os exames laboratoriais revelaram leucocitose por neutrofilia e linfocitose em apenas dois animais. Houve aumento das enzimas creatina-quinase (CK), dehidrogenase láctica (DHL) e da uréia; redução nos níveis séricos de cálcio, fósforo e magnésio. O tempo de tromboplastina parcial ativada (TTPA) aumentou nos equinos que morreram. Os achados de necropsia foram edema do tecido subcutâneo em todo o membro em que foi aplicado o veneno, sufusões no epicárdio dos ventrículos cardíacos esquerdo e direito, bexiga repleta de urina com áreas hemorrágicas em grande parte da mucosa. Ao exame observaram-se fígado com vacuolização moderada difusa, afetando mais a zona intermediária do lóbulo hepático, dilatação dos sinusóides hepáticos leve e rim com dilatação leve dos túbulos uriníferos, principalmente no córtex. 2017-05-17T11:23:05Z 2017-05-17T11:23:05Z 2012-09-28 Dissertação LOPES, Cinthia Tavora de Albuquerque. Aspectos clínico-patológicos do envenenamento experimental por Caudisona durissa em equinos. 2012. 33 f. Dissertação (Mestrado) - Universidade Federal do Pará, Núcleo de Ciências Agrárias e Desenvolvimento Rural, Empresa Brasileira de Pesquisa Agropecuária, Universidade Federal Rural da Amazônia, Belém, 2012. Programa de Pós-Graduação em Ciência Animal. http://repositorio.ufpa.br/jspui/handle/2011/8416 por Acesso Aberto application/pdf Universidade Federal do Pará Empresa Brasileira de Pesquisa Agropecuária Universidade Federal Rural da Amazônia Brasil Campus Universitário de Castanhal UFPA EMBRAPA UFRA Programa de Pós-Graduação em Ciência Animal |
| institution |
Repositório Institucional - Universidade Federal do Pará |
| collection |
RI-UFPA |
| language |
por |
| topic |
Equino Envenenamento Crotalus durissus terrificus Caudisona durissa terrificus Cobra venenosa Veneno Ofídismo CNPQ::CIENCIAS AGRARIAS::MEDICINA VETERINARIA::MEDICINA VETERINARIA PREVENTIVA::SAUDE ANIMAL (PROGRAMAS SANITARIOS) |
| spellingShingle |
Equino Envenenamento Crotalus durissus terrificus Caudisona durissa terrificus Cobra venenosa Veneno Ofídismo CNPQ::CIENCIAS AGRARIAS::MEDICINA VETERINARIA::MEDICINA VETERINARIA PREVENTIVA::SAUDE ANIMAL (PROGRAMAS SANITARIOS) LOPES, Cinthia Távora de Albuquerque Aspectos clínico-patológicos do envenenamento experimental por Caudisona durissa em equinos |
| topic_facet |
Equino Envenenamento Crotalus durissus terrificus Caudisona durissa terrificus Cobra venenosa Veneno Ofídismo CNPQ::CIENCIAS AGRARIAS::MEDICINA VETERINARIA::MEDICINA VETERINARIA PREVENTIVA::SAUDE ANIMAL (PROGRAMAS SANITARIOS) |
| description |
The clinic-pathological picture and laboratory findings in horses experimentally inoculated with the venom of Caudisona durissa terrificus (Crotalus durissus terrificus, according to the former nomenclature) are described. The purpose of this study was to contribute to the understanding of this type of snake accident in horses. The lyophilized venom was diluted into 1ml of a 0.9% saline solution and was inoculated subcutaneously into five horses, at the doses of 0.12mg/kg (one horse), 0.066mg/kg (two horses) and 0.03mg/kg (two horses). The venom caused death of the horse that had received 0.12mg/kg, and of one horse of the two that had received the dose of 0.066mg/kg. The clinical course varied from 27h27min to 52h29min. The second horse inoculated with 0.066mg/kg recovered within 12 days after inoculation. The dose of 0.03mg/kg had a course of 6 to 10 days but did not cause fatal envenomation. The clinical picture in the horses was characterized by swelling of the inoculation site and adjacent areas, by apathy and lowered head, locomotory alterations shown by dragging of the hoves on the ground, decubitus and difficulty to get up, reduction of auricular, palatal, upperlip and threat reflexes, and increase of heart and breathing frequency. The laboratory examination revealed leukocytosis and lymphocytosis in two horses. There was increase of the creatine-kinase (CK), lactic dehydrogenase (DHL) and ureia; reduction in the seric levels of calcium, phosphorus and magnesium. The time of activated partial tromboplastina (TTPA) increased in the horses that died. Post mortem findings were edema of the subcutaneous tissue at the inoculated shoulder, suffusions in the epicard of left and right heart ventricles, bladder replete with urine containing a white-yellowish sediment, and hemorrhagic areas in its mucosa. Histopatologic examination revealed the liver parenchyma with diffuse moderate vacuolation affecting predominantly the intermediate area of the hepatic lobe, and slight dilation of the sinusoides in some areas; in the kidney slight dilation of the uriniferous tubules mainly in the cortex. |
| author_additional |
BARBOSA NETO, José Diomedes |
| author_additionalStr |
BARBOSA NETO, José Diomedes |
| format |
Dissertação |
| author |
LOPES, Cinthia Távora de Albuquerque |
| title |
Aspectos clínico-patológicos do envenenamento experimental por Caudisona durissa em equinos |
| title_short |
Aspectos clínico-patológicos do envenenamento experimental por Caudisona durissa em equinos |
| title_full |
Aspectos clínico-patológicos do envenenamento experimental por Caudisona durissa em equinos |
| title_fullStr |
Aspectos clínico-patológicos do envenenamento experimental por Caudisona durissa em equinos |
| title_full_unstemmed |
Aspectos clínico-patológicos do envenenamento experimental por Caudisona durissa em equinos |
| title_sort |
aspectos clínico-patológicos do envenenamento experimental por caudisona durissa em equinos |
| publisher |
Universidade Federal do Pará |
| publishDate |
2017 |
| url |
http://repositorio.ufpa.br/jspui/handle/2011/8416 |
| _version_ |
1832602877748576256 |
| score |
11.755432 |