Introduction: sepsis is a serious public health problem, leading cause of death in Intensive Care Unit (ICU) worldwide. Objective: this
study evaluated the aggravation and mortality of sepsis patients in ICU, relating to risk factors, different etiologies and therapies.
Methodology: the study was observational descriptive, and evaluated the cases of sepsis (sepsis, severe sepsis and septic shock)
from January 2009 to December 2010. Results: of the 212 patients hospitalized in ICU, 181 presented sepsis at different severities,
whose sepsis mortality in the ICU was 63%, especially in patients with septic shock (53%), followed by severe sepsis (8.3%).
Moreover, the risk factors associated with the aggravation of sepsis were older than 65 years, longer ICU hospitalization time, high
frequency of comorbidities and the use of invasive procedures. The highest consumption of antibiotics was carbapenems, and the
main isolated multiresistant strains were MRSA, VRE, P. aeruginosa and A. baumannii resistant to carbapenems. Conclusion: this
study showed a high mortality from sepsis patients in the ICU, especially in patients with septic shock with comorbidities, who
underwent invasive procedures and longer hospitalization time.
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