A New Prenylisoflavone from the Antifungal Extract of Leaves of Vatairea guianensis Aubl.
A new compound, 5,7,3'-trihydroxy-4'-methoxy-8-prenylisoflavone, was isolated from the leaves of Vatairea guianensis Aubl. (Fabaceae), together with two known isoflavones lupiwighteone and 5,7,4'-trihydroxy-3'-methoxy-8-prenylisoflavone. All isolated compounds were characterized based on infrared (I...
| Autor principal: | SOUZA, Ronilson Freitas de |
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| Outros Autores: | SILVA, Geilson Alcantara da, ARRUDA, Alberto Cardoso, SILVA, Milton Nascimento da, SANTOS, Alberdan Silva, GRISÓLIA, Daniella Paternostro de Araújo, SILVA, Moisés Batista da, ARRUDA, Mara Silvia Pinheiro |
| Grau: | Artigo |
| Idioma: | por |
| Publicado em: |
Universidade Federal do Pará
2017
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| Assuntos: | |
| Acesso em linha: |
http://repositorio.ufpa.br/jspui/handle/2011/8875 |
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ir-2011-8875 |
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dspace |
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ir-2011-88752023-11-22T13:01:08Z A New Prenylisoflavone from the Antifungal Extract of Leaves of Vatairea guianensis Aubl. SOUZA, Ronilson Freitas de SILVA, Geilson Alcantara da ARRUDA, Alberto Cardoso SILVA, Milton Nascimento da SANTOS, Alberdan Silva GRISÓLIA, Daniella Paternostro de Araújo SILVA, Moisés Batista da ARRUDA, Mara Silvia Pinheiro Antifúngicos Vatairea guianensis Flavonóides Fabaceae Prenilisoflavona A new compound, 5,7,3'-trihydroxy-4'-methoxy-8-prenylisoflavone, was isolated from the leaves of Vatairea guianensis Aubl. (Fabaceae), together with two known isoflavones lupiwighteone and 5,7,4'-trihydroxy-3'-methoxy-8-prenylisoflavone. All isolated compounds were characterized based on infrared (IR), UV, 1H and 13C nuclear magnetic resonance (NMR), including 2D NMR analyses and high resolution mass spectrometry. The ethanolic extract from V. guianensis leaves displayed activity against Candida dubliniensis, C. albicans and C. krusei. However, the EtOAc fraction from that extract exhibited more significant activity than the ethanolic extract, showing antifungal activity for all fungi species investigated. The major compound 5,7,3'-trihydroxy-4'-methoxy-8-prenylisoflavone isolated from that EtOAc fraction was also active against C. parapsilosis and C. dubliniensis. 2017-07-18T20:08:52Z 2017-07-18T20:08:52Z 2017-06 Artigo de Periódico SOUZA, Ronilson Freitas de et al. A New Prenylisoflavone from the Antifungal Extract of Leaves of Vatairea guianensis Aubl. Journal of the Brazilian Chemical Society, São Paulo, v. 28, n. 6, p. 1132-1136, jun. 2017. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532017000601132&lng=pt&nrm=iso>. Acesso em: 18 jul. 2017. <http://dx.doi.org/10.21577/0103-5053.20160250>. 1678-4790 http://repositorio.ufpa.br/jspui/handle/2011/8875 por Journal of the Brazilian Chemical Society Acesso Aberto application/pdf Universidade Federal do Pará Brasil UFPA |
| institution |
Repositório Institucional - Universidade Federal do Pará |
| collection |
RI-UFPA |
| language |
por |
| topic |
Antifúngicos Vatairea guianensis Flavonóides Fabaceae Prenilisoflavona |
| spellingShingle |
Antifúngicos Vatairea guianensis Flavonóides Fabaceae Prenilisoflavona SOUZA, Ronilson Freitas de A New Prenylisoflavone from the Antifungal Extract of Leaves of Vatairea guianensis Aubl. |
| topic_facet |
Antifúngicos Vatairea guianensis Flavonóides Fabaceae Prenilisoflavona |
| description |
A new compound, 5,7,3'-trihydroxy-4'-methoxy-8-prenylisoflavone, was isolated from the leaves of Vatairea guianensis Aubl. (Fabaceae), together with two known isoflavones lupiwighteone and 5,7,4'-trihydroxy-3'-methoxy-8-prenylisoflavone. All isolated compounds were characterized based on infrared (IR), UV, 1H and 13C nuclear magnetic resonance (NMR), including 2D NMR analyses and high resolution mass spectrometry. The ethanolic extract from V. guianensis leaves displayed activity against Candida dubliniensis, C. albicans and C. krusei. However, the EtOAc fraction from that extract exhibited more significant activity than the ethanolic extract, showing antifungal activity for all fungi species investigated. The major compound 5,7,3'-trihydroxy-4'-methoxy-8-prenylisoflavone isolated from that EtOAc fraction was also active against C. parapsilosis and C. dubliniensis. |
| format |
Artigo |
| author |
SOUZA, Ronilson Freitas de |
| author2 |
SILVA, Geilson Alcantara da ARRUDA, Alberto Cardoso SILVA, Milton Nascimento da SANTOS, Alberdan Silva GRISÓLIA, Daniella Paternostro de Araújo SILVA, Moisés Batista da ARRUDA, Mara Silvia Pinheiro |
| author2Str |
SILVA, Geilson Alcantara da ARRUDA, Alberto Cardoso SILVA, Milton Nascimento da SANTOS, Alberdan Silva GRISÓLIA, Daniella Paternostro de Araújo SILVA, Moisés Batista da ARRUDA, Mara Silvia Pinheiro |
| title |
A New Prenylisoflavone from the Antifungal Extract of Leaves of Vatairea guianensis Aubl. |
| title_short |
A New Prenylisoflavone from the Antifungal Extract of Leaves of Vatairea guianensis Aubl. |
| title_full |
A New Prenylisoflavone from the Antifungal Extract of Leaves of Vatairea guianensis Aubl. |
| title_fullStr |
A New Prenylisoflavone from the Antifungal Extract of Leaves of Vatairea guianensis Aubl. |
| title_full_unstemmed |
A New Prenylisoflavone from the Antifungal Extract of Leaves of Vatairea guianensis Aubl. |
| title_sort |
new prenylisoflavone from the antifungal extract of leaves of vatairea guianensis aubl. |
| publisher |
Universidade Federal do Pará |
| publishDate |
2017 |
| url |
http://repositorio.ufpa.br/jspui/handle/2011/8875 |
| _version_ |
1832603844918378496 |
| score |
11.755432 |