Studies on the immunology and serology of leishmaniasis - II. Cross-immunity experiments among different forms of american cutaneous leishmaniasis in monkeys (Publicado originalmente em 1966)
The Rhesus monkey (Macaca mulatta) was found to be readily infected with either L. mexicana or L. braziliensis, and cross immunity between the two parasites has been studied in these animals. Monkeys recovered from L. mexicana lesions were completely resistant to re-infection with the same paras...
| Autor principal: | Lainson, Ralph |
|---|---|
| Outros Autores: | Bray, R. S |
| Grau: | Cap?tulo de Livro |
| Idioma: | eng |
| Publicado em: |
MS/SVS/Instituto Evandro Chagas
2018
|
| Assuntos: | |
| Acesso em linha: |
http://patua.iec.gov.br//handle/iec/3478 |
| Resumo: |
|---|
|
The Rhesus monkey (Macaca mulatta) was found to be
readily infected with either L. mexicana or L. braziliensis, and cross
immunity between the two parasites has been studied in these animals.
Monkeys recovered from L. mexicana lesions were
completely resistant to re-infection with the same parasite.
Monkeys recovered from L. braziliensis infection were
immune to further infection with the same strain of parasite.
Monkeys recovered from L. mexicana infection were
completely resistant to challenge with a strain of L. braziliensis isolated
from a patient with espundia, to which they were normally susceptible.
On the other hand, monkeys immune to L. braziliensis could be infected
with L. mexicana but the resultant infection was milder and short-lived.
The question of possible immunization of forest workers
against muco-cutaneous leishmaniasis by vaccination with living
leptomonads of L. mexicana is discussed. In areas where espundia is a
common hazard it might be considered that a prior, self-limiting and
single lesion of the chiclero?s ulcer type is a preferable alternative. |