Analysis of an acute Chagas disease outbreak in the Brazilian Amazon: human cases, triatomines, reservoir mammals and parasites
An outbreak of Chagas disease occurred in Mazag?o, Amap?, Brazilian Amazon in 1996. Seventeen of 26 inhabitants presented symptoms compatible with acute Chagas disease and were submitted to parasitological and serological tests. All 17 were positive in at least one parasitological test and 11 wer...
| Autor principal: | Valente, Sebasti?o Aldo da Silva |
|---|---|
| Outros Autores: | Valente, Vera da Costa, Pinto, Ana Yec? das Neves, C?sar, Maria de Jesus Barbosa, Santos, Marivaldo Pican?o dos, Miranda, Cl?vis Omar S?, Cuervo, Patricia, Fernandes, Octavio |
| Grau: | Artigo |
| Idioma: | eng |
| Publicado em: |
Oxford University Press
2019
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| Assuntos: | |
| Acesso em linha: |
http://patua.iec.gov.br//handle/iec/3553 |
| Resumo: |
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An outbreak of Chagas disease occurred in Mazag?o, Amap?, Brazilian Amazon in
1996. Seventeen of 26 inhabitants presented symptoms compatible with acute Chagas disease
and were submitted to parasitological and serological tests. All 17 were positive in at least
one parasitological test and 11 were also IgM or IgG anti-Trypanosoma cruzi positive. The nine
asymptomatic patients were negative for parasites and one was positive for IgG anti-T. cruzi.
Sixty-eight triatomines were captured (66 Rhodnius pictipes; two Panstrongylus geniculatus); 45
were infected with T. cruzi (43 R. pictipes; two P. geniculatus). Thirteen trypanosomatid strains
were isolated: eight from humans and five from R. pictipes. Four were genotyped as T. cruzi I
(two from humans; two from R. pictipes), seven as T. cruzi Z3 (six from humans; one from R. pictipes) and two as T. cruzi Z3 and T. rangeli (from R. pictipes). Treatment started for all patients
leading to a decrease in parasitaemia in 16 during the follow-up period (6 months, 1, 5 and 7
years). All were serologically negative 7 years post-treatment. There was an overlap of genotypes in the same ecotope, raising the possibility of transmission through the oral route and the
need for early therapeutic intervention for better patient management in the Brazilian Amazon. |