Yellow fever virus modulates cytokine mRNA expression and induces activation of caspase 3/7 in the human hepatocarcinoma cell line HepG2

Holanda, Gustavo Moraes; Casseb, Samir Mansour Moraes; Quaresma, Juarez Antonio Sim?es; Vasconcelos, Pedro Fernando da Costa; cruz, Ana Cec?lia Ribeiro

Artigo

Yellow fever virus modulates cytokine mRNA expression and induces activation of caspase 3/7 in the human hepatocarcinoma cell line HepG2

Yellow fever virus (YFV) penetrates the skin through the bite of a vector mosquito and spreads to various organs, mainly the liver, where it causes lesions and induces necrosis and apoptosis. We evaluated the mRNA expression of various cytokines and the activation of caspases in HepG2 cells infected...

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Autor principal:	Holanda, Gustavo Moraes
Outros Autores:	Casseb, Samir Mansour Moraes, Quaresma, Juarez Antonio Sim?es, Vasconcelos, Pedro Fernando da Costa, cruz, Ana Cec?lia Ribeiro
Grau:	Artigo
Idioma:	eng
Publicado em:	Springer Verlag 2019
Assuntos:	Febre Amarela / virologia F?gado / patologia F?gado / les?es Macr?fagos do F?gado RNA Mensageiro / gen?tica Citocinas Receptores de Citocinas
Acesso em linha:	http://patua.iec.gov.br//handle/iec/3609

id	ir-iec-3609
recordtype	dspace
spelling	ir-iec-36092019-02-25T17:17:28Z Yellow fever virus modulates cytokine mRNA expression and induces activation of caspase 3/7 in the human hepatocarcinoma cell line HepG2 Holanda, Gustavo Moraes Casseb, Samir Mansour Moraes Quaresma, Juarez Antonio Sim?es Vasconcelos, Pedro Fernando da Costa cruz, Ana Cec?lia Ribeiro Febre Amarela / virologia F?gado / patologia F?gado / les?es Macr?fagos do F?gado RNA Mensageiro / gen?tica Citocinas Receptores de Citocinas Yellow fever virus (YFV) penetrates the skin through the bite of a vector mosquito and spreads to various organs, mainly the liver, where it causes lesions and induces necrosis and apoptosis. We evaluated the mRNA expression of various cytokines and the activation of caspases in HepG2 cells infected with YFV. We observed that interferon-? (IFN-?) expression decreased and IFN-?, transforming growth factor (TGF)-? IIIR, interleukin (IL)-6, and IL-8 expression increased in cells infected with genotype 1. In contrast, TNF-? expression increased in cells infected with genotype 2 but not with genotype 1. This provides insights into the role of cytokine regulation in yellow fever. 2019-02-25T17:04:05Z 2019-02-25T17:04:05Z 2019 Artigo HOLANDA, Gustavo Moraes et al. Yellow fever virus modulates cytokine mRNA expression and induces activation of caspase 3/7 in the human hepatocarcinoma cell line HepG2. Archives of Virology, v. xx, n. xx, p.xx, Feb. 2019. (Epub ahead of print) 0304-8608 http://patua.iec.gov.br//handle/iec/3609 10.1007/s00705-019-04171-7 eng Acesso Embargado application/pdf Springer Verlag
institution	Instituto Evandro Chagas (IEC)
collection	PATUA
language	eng
topic	Febre Amarela / virologia F?gado / patologia F?gado / les?es Macr?fagos do F?gado RNA Mensageiro / gen?tica Citocinas Receptores de Citocinas
spellingShingle	Febre Amarela / virologia F?gado / patologia F?gado / les?es Macr?fagos do F?gado RNA Mensageiro / gen?tica Citocinas Receptores de Citocinas Holanda, Gustavo Moraes Yellow fever virus modulates cytokine mRNA expression and induces activation of caspase 3/7 in the human hepatocarcinoma cell line HepG2
topic_facet	Febre Amarela / virologia F?gado / patologia F?gado / les?es Macr?fagos do F?gado RNA Mensageiro / gen?tica Citocinas Receptores de Citocinas
description	Yellow fever virus (YFV) penetrates the skin through the bite of a vector mosquito and spreads to various organs, mainly the liver, where it causes lesions and induces necrosis and apoptosis. We evaluated the mRNA expression of various cytokines and the activation of caspases in HepG2 cells infected with YFV. We observed that interferon-? (IFN-?) expression decreased and IFN-?, transforming growth factor (TGF)-? IIIR, interleukin (IL)-6, and IL-8 expression increased in cells infected with genotype 1. In contrast, TNF-? expression increased in cells infected with genotype 2 but not with genotype 1. This provides insights into the role of cytokine regulation in yellow fever.
format	Artigo
author	Holanda, Gustavo Moraes
author2	Casseb, Samir Mansour Moraes Quaresma, Juarez Antonio Sim?es Vasconcelos, Pedro Fernando da Costa cruz, Ana Cec?lia Ribeiro
author2Str	Casseb, Samir Mansour Moraes Quaresma, Juarez Antonio Sim?es Vasconcelos, Pedro Fernando da Costa cruz, Ana Cec?lia Ribeiro
title	Yellow fever virus modulates cytokine mRNA expression and induces activation of caspase 3/7 in the human hepatocarcinoma cell line HepG2
title_short	Yellow fever virus modulates cytokine mRNA expression and induces activation of caspase 3/7 in the human hepatocarcinoma cell line HepG2
title_full	Yellow fever virus modulates cytokine mRNA expression and induces activation of caspase 3/7 in the human hepatocarcinoma cell line HepG2
title_fullStr	Yellow fever virus modulates cytokine mRNA expression and induces activation of caspase 3/7 in the human hepatocarcinoma cell line HepG2
title_full_unstemmed	Yellow fever virus modulates cytokine mRNA expression and induces activation of caspase 3/7 in the human hepatocarcinoma cell line HepG2
title_sort	yellow fever virus modulates cytokine mrna expression and induces activation of caspase 3/7 in the human hepatocarcinoma cell line hepg2
publisher	Springer Verlag
publishDate	2019
url	http://patua.iec.gov.br//handle/iec/3609
_version_	1717584375643635712
score	11.653393

Yellow fever virus modulates cytokine mRNA expression and induces activation of caspase 3/7 in the human hepatocarcinoma cell line HepG2

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