Reduced?Leishmania?(L.)?infantum chagasi?parasitic loads in humans exposed to?Lutzomyia longipalpis?bites in the Amazon region of Brazil
We performed a cross-sectional survey in humans to evaluate Lutzomyia longipalpis, i.e. sand fly vector, bite exposure association with Leishmania (Leishmania) infantum chagasi infection in Bujar? municipality, Northern Brazil, an endemic area for visceral leishmaniasis. In recruited individuals, w...
| Autor principal: | Laurenti, M?rcia Dalastra |
|---|---|
| Outros Autores: | Chaves, Luis Fernando, Tomokane, Tha?se Yumie, Abbasi, Ibrahim, Warburg, Alon, Silveira, Fernando Tobias |
| Grau: | Artigo |
| Idioma: | eng |
| Publicado em: |
Cambridge University Press
2019
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| Assuntos: | |
| Acesso em linha: |
http://patua.iec.gov.br//handle/iec/3699 |
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ir-iec-3699 |
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ir-iec-36992019-05-17T18:45:23Z Reduced?Leishmania?(L.)?infantum chagasi?parasitic loads in humans exposed to?Lutzomyia longipalpis?bites in the Amazon region of Brazil Laurenti, M?rcia Dalastra Chaves, Luis Fernando Tomokane, Tha?se Yumie Abbasi, Ibrahim Warburg, Alon Silveira, Fernando Tobias Leishmaniose Visceral / parasitologia Infec??es por Protozo?rios / parasitologia Psychodidae / parasitologia Vetores de Doen?as Leishmaniose / parasitologia T?cnicas Imunoenzim?ticas / m?todos Bujar? (PA) We performed a cross-sectional survey in humans to evaluate Lutzomyia longipalpis, i.e. sand fly vector, bite exposure association with Leishmania (Leishmania) infantum chagasi infection in Bujar? municipality, Northern Brazil, an endemic area for visceral leishmaniasis. In recruited individuals, which were stratified by sex and age, we measured L. (L.) i. chagasi parasitic loads with quantitative polymerase chain reaction (qPCR), exposure to sand fly bites with an anti-saliva immunoglobulin G enzyme-linked immunosorbent assay and performed immunological diagnostic tests, in order to evaluate the association between exposure to sand fly bites, and infection. The prevalence increased from 11% when using immunological diagnostic tests to 28% when using qPCR, being around that value for all age classes, but children below 5 years (40%) and people over 60 years (15%). The association between PCR-based L. (L.) i. chagasi prevalence and saliva exposure was convex, reflecting the fact that at both high and low saliva exposure the PCR-based L. (L.) i. chagasi prevalence decreases. This scenario indicates that low sand fly exposure is likely associated with low parasite transmission, while high anti-saliva prevalence, i.e. a large sand fly bite exposure could be associated with anti-Leishmania protective immune mechanisms driven by vector saliva and/or increased parasite exposure S?o Paulo Research Foundation-Hebrew University of Jerusalem (FAPESP-HUJ) collaborative grant #2011/ 51404-9, Brazilian Ministry of Health and LIM50 HCFMUSP. M.D.L. is a Research Fellows from CNPq, Brazil. L.F.C. was funded by Nagasaki University (Program for Nurturing Global Leaders in Tropical and Emerging Communicable Diseases). 2019-05-17T18:13:40Z 2019-05-17T18:13:40Z 2017 Artigo LAURENTI, M?rcia Dalastra et al. Reduced?Leishmania?(L.)?infantum chagasi?parasitic loads in humans exposed to?Lutzomyia longipalpis?bites in the Amazon region of Brazil. Parasitology Open, v. 3, n. 2, p. 1-10, Mar. 2017. 2055-7094 http://patua.iec.gov.br//handle/iec/3699 10.1017/pao.2017.2 eng Acesso Aberto application/pdf Cambridge University Press |
| institution |
Instituto Evandro Chagas (IEC) |
| collection |
PATUA |
| language |
eng |
| topic |
Leishmaniose Visceral / parasitologia Infec??es por Protozo?rios / parasitologia Psychodidae / parasitologia Vetores de Doen?as Leishmaniose / parasitologia T?cnicas Imunoenzim?ticas / m?todos Bujar? (PA) |
| spellingShingle |
Leishmaniose Visceral / parasitologia Infec??es por Protozo?rios / parasitologia Psychodidae / parasitologia Vetores de Doen?as Leishmaniose / parasitologia T?cnicas Imunoenzim?ticas / m?todos Bujar? (PA) Laurenti, M?rcia Dalastra Reduced?Leishmania?(L.)?infantum chagasi?parasitic loads in humans exposed to?Lutzomyia longipalpis?bites in the Amazon region of Brazil |
| topic_facet |
Leishmaniose Visceral / parasitologia Infec??es por Protozo?rios / parasitologia Psychodidae / parasitologia Vetores de Doen?as Leishmaniose / parasitologia T?cnicas Imunoenzim?ticas / m?todos Bujar? (PA) |
| description |
We performed a cross-sectional survey in humans to evaluate Lutzomyia longipalpis, i.e. sand fly vector, bite exposure association with Leishmania (Leishmania) infantum chagasi infection in Bujar? municipality, Northern Brazil, an endemic area
for visceral leishmaniasis. In recruited individuals, which were stratified by sex and age, we measured L. (L.) i. chagasi
parasitic loads with quantitative polymerase chain reaction (qPCR), exposure to sand fly bites with an anti-saliva immunoglobulin G enzyme-linked immunosorbent assay and performed immunological diagnostic tests, in order to evaluate the
association between exposure to sand fly bites, and infection. The prevalence increased from 11% when using immunological diagnostic tests to 28% when using qPCR, being around that value for all age classes, but children below 5 years
(40%) and people over 60 years (15%). The association between PCR-based L. (L.) i. chagasi prevalence and saliva exposure
was convex, reflecting the fact that at both high and low saliva exposure the PCR-based L. (L.) i. chagasi prevalence
decreases. This scenario indicates that low sand fly exposure is likely associated with low parasite transmission, while
high anti-saliva prevalence, i.e. a large sand fly bite exposure could be associated with anti-Leishmania protective
immune mechanisms driven by vector saliva and/or increased parasite exposure |
| format |
Artigo |
| author |
Laurenti, M?rcia Dalastra |
| author2 |
Chaves, Luis Fernando Tomokane, Tha?se Yumie Abbasi, Ibrahim Warburg, Alon Silveira, Fernando Tobias |
| author2Str |
Chaves, Luis Fernando Tomokane, Tha?se Yumie Abbasi, Ibrahim Warburg, Alon Silveira, Fernando Tobias |
| title |
Reduced?Leishmania?(L.)?infantum chagasi?parasitic loads in humans exposed to?Lutzomyia longipalpis?bites in the Amazon region of Brazil |
| title_short |
Reduced?Leishmania?(L.)?infantum chagasi?parasitic loads in humans exposed to?Lutzomyia longipalpis?bites in the Amazon region of Brazil |
| title_full |
Reduced?Leishmania?(L.)?infantum chagasi?parasitic loads in humans exposed to?Lutzomyia longipalpis?bites in the Amazon region of Brazil |
| title_fullStr |
Reduced?Leishmania?(L.)?infantum chagasi?parasitic loads in humans exposed to?Lutzomyia longipalpis?bites in the Amazon region of Brazil |
| title_full_unstemmed |
Reduced?Leishmania?(L.)?infantum chagasi?parasitic loads in humans exposed to?Lutzomyia longipalpis?bites in the Amazon region of Brazil |
| title_sort |
reduced?leishmania?(l.)?infantum chagasi?parasitic loads in humans exposed to?lutzomyia longipalpis?bites in the amazon region of brazil |
| publisher |
Cambridge University Press |
| publishDate |
2019 |
| url |
http://patua.iec.gov.br//handle/iec/3699 |
| _version_ |
1717584477411082240 |
| score |
11.687526 |