Severe anemia affects both splenectomized and nonsplenectomized plasmodium falciparum-infected Aotus infulatus monkeys
Severe anemia is the earliest and a frequently fatal complication of Plasmodium falciparum infection. Here we describe Aotus infulatus as a primate model suitable to study this malaria complication. Both non-splenectomized and splenectomized monkeys receiving different inocula of P. falciparum FVO s...
| Autor principal: | Carvalho, Leonardo J. de Moura |
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| Outros Autores: | Alves, Francisco Ac?cio, Oliveira, Salma Gomes de, Valle, Rodrigo del Rio do, Fernandes, Andr?a A. Morais, Muniz, Jos? Augusto Pereira Carneiro, Daniel-Ribeiro, Cl?udio Tadeu |
| Grau: | Artigo |
| Idioma: | eng |
| Publicado em: |
Instituto Oswaldo Cruz
2019
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| Acesso em linha: |
http://patua.iec.gov.br//handle/iec/3738 |
| Resumo: |
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Severe anemia is the earliest and a frequently fatal complication of Plasmodium falciparum infection. Here we describe Aotus infulatus as a primate model suitable to study this malaria complication. Both non-splenectomized and splenectomized monkeys receiving different inocula of P. falciparum FVO strain presented large (> 50%) decreases in hematocrit values during infection. Non-splenectomized animals were able to control parasite growth (parasitemia did not exceed 4%), but they had to be treated because of severe anemia. Three of 4 splenectomized monkeys did not control parasitemia and were treated, but developed severe anemia after treatment when presenting a negative blood film. Destruction of parasitized red blood cells alone cannot account for the degree of anemia. Non-splenectomized monkeys repeatedly infected with homologous parasites became rapidly and progressively resistant to reinfection and to the development of severe anemia. The data presented here point to A. infulatus as a suitable model for studying the pathogenesis of severe malarial infection. |