Genomic and phylogenetic characterization of brazilian yellow fever virus strains
Globally, yellow fever virus infects nearly 200,000 people, leading to 30,000 deaths annually. Although the virus is endemic to Latin America, only a single genome from this region has been sequenced. Here, we report 12 Brazilian yellow fever virus completegenomes, their genetic traits, phylogenetic...
| Autor principal: | Nunes, M?rcio Roberto Teixeira |
|---|---|
| Outros Autores: | Palacios, Gustavo, Cardoso, Jedson Ferreira, Martins, L?via Car?cio, Sousa Junior, Edivaldo C, Lima, Clayton P. S. de, Medeiros, Daniele Barbosa de Almeida, Savji, Nazir, Desai, Aaloki, Rodrigues, Sueli Guerreiro, Carvalho, Val?ria Lima, Lipkin, W. Ian |
| Grau: | Artigo |
| Idioma: | eng |
| Publicado em: |
American Society for Microbiology
2016
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| Assuntos: | |
| Acesso em linha: |
http://patua.iec.gov.br/handle/iec/378 |
| id |
ir-iec-378 |
|---|---|
| recordtype |
dspace |
| spelling |
ir-iec-3782019-08-19T17:10:07Z Genomic and phylogenetic characterization of brazilian yellow fever virus strains Nunes, M?rcio Roberto Teixeira Palacios, Gustavo Cardoso, Jedson Ferreira Martins, L?via Car?cio Sousa Junior, Edivaldo C Lima, Clayton P. S. de Medeiros, Daniele Barbosa de Almeida Savji, Nazir Desai, Aaloki Rodrigues, Sueli Guerreiro Carvalho, Val?ria Lima Lipkin, W. Ian Febre Amarela / transmiss?o V?rus da Febre Amarela Globally, yellow fever virus infects nearly 200,000 people, leading to 30,000 deaths annually. Although the virus is endemic to Latin America, only a single genome from this region has been sequenced. Here, we report 12 Brazilian yellow fever virus completegenomes, their genetic traits, phylogenetic characterization, and phylogeographic dynamics. Variable 3= noncoding region (3=NCR) patterns and specific mutations throughout the open reading frame altered predicted secondary structures. Our findingssuggest that whereas the introduction of yellow fever virus in Brazil led to genotype I-predominant dispersal throughout South and Central Americas, genotype II remained confined to Bolivia, Peru, and the western Brazilian Amazon. 2016-01-26T11:22:40Z 2016-01-26T11:22:40Z 2012 Artigo NUNES, M?rcio Roberto Teixeira et al. Genomic and phylogenetic characterization of brazilian yellow fever virus strains. Journal of Virology, v. 86, n. 24, p. 13263-13271, Dec. 2012 http://patua.iec.gov.br/handle/iec/378 10.1128/JVI.00565-12 eng Acesso Aberto application/pdf application/pdf American Society for Microbiology |
| institution |
Instituto Evandro Chagas (IEC) |
| collection |
PATUA |
| language |
eng |
| topic |
Febre Amarela / transmiss?o V?rus da Febre Amarela |
| spellingShingle |
Febre Amarela / transmiss?o V?rus da Febre Amarela Nunes, M?rcio Roberto Teixeira Genomic and phylogenetic characterization of brazilian yellow fever virus strains |
| topic_facet |
Febre Amarela / transmiss?o V?rus da Febre Amarela |
| description |
Globally, yellow fever virus infects nearly 200,000 people, leading to 30,000 deaths annually. Although the virus is endemic to Latin America, only a single genome from this region has been sequenced. Here, we report 12 Brazilian yellow fever virus completegenomes, their genetic traits, phylogenetic characterization, and phylogeographic dynamics. Variable 3= noncoding region (3=NCR) patterns and specific mutations throughout the open reading frame altered predicted secondary structures. Our findingssuggest that whereas the introduction of yellow fever virus in Brazil led to genotype I-predominant dispersal throughout South and Central Americas, genotype II remained confined to Bolivia, Peru, and the western Brazilian Amazon. |
| format |
Artigo |
| author |
Nunes, M?rcio Roberto Teixeira |
| author2 |
Palacios, Gustavo Cardoso, Jedson Ferreira Martins, L?via Car?cio Sousa Junior, Edivaldo C Lima, Clayton P. S. de Medeiros, Daniele Barbosa de Almeida Savji, Nazir Desai, Aaloki Rodrigues, Sueli Guerreiro Carvalho, Val?ria Lima Lipkin, W. Ian |
| author2Str |
Palacios, Gustavo Cardoso, Jedson Ferreira Martins, L?via Car?cio Sousa Junior, Edivaldo C Lima, Clayton P. S. de Medeiros, Daniele Barbosa de Almeida Savji, Nazir Desai, Aaloki Rodrigues, Sueli Guerreiro Carvalho, Val?ria Lima Lipkin, W. Ian |
| title |
Genomic and phylogenetic characterization of brazilian yellow fever virus strains |
| title_short |
Genomic and phylogenetic characterization of brazilian yellow fever virus strains |
| title_full |
Genomic and phylogenetic characterization of brazilian yellow fever virus strains |
| title_fullStr |
Genomic and phylogenetic characterization of brazilian yellow fever virus strains |
| title_full_unstemmed |
Genomic and phylogenetic characterization of brazilian yellow fever virus strains |
| title_sort |
genomic and phylogenetic characterization of brazilian yellow fever virus strains |
| publisher |
American Society for Microbiology |
| publishDate |
2016 |
| url |
http://patua.iec.gov.br/handle/iec/378 |
| _version_ |
1717584449342799872 |
| score |
11.755432 |