Mesenchymal stem cells in dogs with demyelinating leukoencephalitis as an experimental model of multiple sclerosis
Researchers have used dogs with neurological sequelae caused by distemper as an experimental model for multiple sclerosis, owing to the similarities of the neuropathological changes between distemper virus-induced demyelinating leukoencephalitis and multiple sclerosis in humans. However, little is k...
| Autor principal: | Pinheiro, Luane Lopes |
|---|---|
| Outros Autores: | Lima, Ana Rita de, Martins, Danielli Martinelli, Oliveira, Edivaldo Herculano Correa de, Souza, Michel Platini Caldas de, Miranda, Carla Maria Figueiredo de Carvalho, Beltr?o-Braga, Patr?cia Cristina Baleeiro, Russo, Fabiele Baldino, Pignatari, Graciela Concei??o, Silva filho, Ednaldo da, Branco, ?rika |
| Grau: | Artigo |
| Idioma: | eng |
| Publicado em: |
Elsevier
2019
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| Assuntos: | |
| Acesso em linha: |
http://patua.iec.gov.br//handle/iec/3795 |
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ir-iec-3795 |
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dspace |
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ir-iec-37952019-08-09T14:06:42Z Mesenchymal stem cells in dogs with demyelinating leukoencephalitis as an experimental model of multiple sclerosis Pinheiro, Luane Lopes Lima, Ana Rita de Martins, Danielli Martinelli Oliveira, Edivaldo Herculano Correa de Souza, Michel Platini Caldas de Miranda, Carla Maria Figueiredo de Carvalho Beltr?o-Braga, Patr?cia Cristina Baleeiro Russo, Fabiele Baldino Pignatari, Graciela Concei??o Silva filho, Ednaldo da Branco, ?rika Biologia Celular Neuroci?ncias Esclerose M?ltipla / patologia C?lulas-Tronco Mesenquimais / citologia Sistema Nervoso Central Cinomose C?es Researchers have used dogs with neurological sequelae caused by distemper as an experimental model for multiple sclerosis, owing to the similarities of the neuropathological changes between distemper virus-induced demyelinating leukoencephalitis and multiple sclerosis in humans. However, little is known about the role of mesenchymal stem cells in treating such clinical conditions. Therefore, we investigated the use of mesenchymal stem cells in four dogs with neurological lesions caused by the distemper virus. During the first year after cellular therapy, the animals did not demonstrate significant changes in their locomotive abilities. However, the intense (Grade V) myoclonus in three animals was reduced to a moderate (Grade IV) level. At one year after the mesenchymal stem cell infusions, three animals regained functional ambulation (Grade I), and all four dogs started to move independently (Grades I and II). In two animals, the myoclonic severity had become mild (Grade III). It was concluded that the use of mesenchymal stem cells could improve the quality of life of dogs with neurological sequelae caused by canine distemper, thus presenting hope for similar positive results in human patients with multiple sclerosis. Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior (CAPES), Brasil (Finance Code 001). 2019-06-27T14:15:38Z 2019-06-27T14:15:38Z 2019 Artigo PINHEIRO, Luane Lopes et al. Mesenchymal stem cells in dogs with demyelinating leukoencephalitis as an experimental model of multiple sclerosis. Heliyon, v. xx, n. xx, p. xx, 2019. 2405-8440 http://patua.iec.gov.br//handle/iec/3795 10.1016/j.heliyon.2019.e01857 eng Acesso Aberto application/pdf Elsevier |
| institution |
Instituto Evandro Chagas (IEC) |
| collection |
PATUA |
| language |
eng |
| topic |
Biologia Celular Neuroci?ncias Esclerose M?ltipla / patologia C?lulas-Tronco Mesenquimais / citologia Sistema Nervoso Central Cinomose C?es |
| spellingShingle |
Biologia Celular Neuroci?ncias Esclerose M?ltipla / patologia C?lulas-Tronco Mesenquimais / citologia Sistema Nervoso Central Cinomose C?es Pinheiro, Luane Lopes Mesenchymal stem cells in dogs with demyelinating leukoencephalitis as an experimental model of multiple sclerosis |
| topic_facet |
Biologia Celular Neuroci?ncias Esclerose M?ltipla / patologia C?lulas-Tronco Mesenquimais / citologia Sistema Nervoso Central Cinomose C?es |
| description |
Researchers have used dogs with neurological sequelae caused by distemper as an experimental model for multiple sclerosis, owing to the similarities of the neuropathological changes between distemper virus-induced demyelinating leukoencephalitis and multiple sclerosis in humans. However, little is known about the role of mesenchymal stem cells in treating such clinical conditions. Therefore, we investigated the use of mesenchymal stem cells in four dogs with neurological lesions caused by the distemper virus. During the first year after cellular therapy, the animals did not demonstrate significant changes in their locomotive abilities. However, the intense (Grade V) myoclonus in three animals was reduced to a moderate (Grade IV) level. At one year after the mesenchymal stem cell infusions, three animals regained functional ambulation (Grade I), and all four dogs started to move independently (Grades I and II). In two animals, the myoclonic severity had become mild (Grade III). It was concluded that the use of mesenchymal stem cells could improve the quality of life of dogs with neurological sequelae caused by canine distemper, thus presenting hope for similar positive results in human patients with multiple sclerosis. |
| format |
Artigo |
| author |
Pinheiro, Luane Lopes |
| author2 |
Lima, Ana Rita de Martins, Danielli Martinelli Oliveira, Edivaldo Herculano Correa de Souza, Michel Platini Caldas de Miranda, Carla Maria Figueiredo de Carvalho Beltr?o-Braga, Patr?cia Cristina Baleeiro Russo, Fabiele Baldino Pignatari, Graciela Concei??o Silva filho, Ednaldo da Branco, ?rika |
| author2Str |
Lima, Ana Rita de Martins, Danielli Martinelli Oliveira, Edivaldo Herculano Correa de Souza, Michel Platini Caldas de Miranda, Carla Maria Figueiredo de Carvalho Beltr?o-Braga, Patr?cia Cristina Baleeiro Russo, Fabiele Baldino Pignatari, Graciela Concei??o Silva filho, Ednaldo da Branco, ?rika |
| title |
Mesenchymal stem cells in dogs with demyelinating leukoencephalitis as an experimental model of multiple sclerosis |
| title_short |
Mesenchymal stem cells in dogs with demyelinating leukoencephalitis as an experimental model of multiple sclerosis |
| title_full |
Mesenchymal stem cells in dogs with demyelinating leukoencephalitis as an experimental model of multiple sclerosis |
| title_fullStr |
Mesenchymal stem cells in dogs with demyelinating leukoencephalitis as an experimental model of multiple sclerosis |
| title_full_unstemmed |
Mesenchymal stem cells in dogs with demyelinating leukoencephalitis as an experimental model of multiple sclerosis |
| title_sort |
mesenchymal stem cells in dogs with demyelinating leukoencephalitis as an experimental model of multiple sclerosis |
| publisher |
Elsevier |
| publishDate |
2019 |
| url |
http://patua.iec.gov.br//handle/iec/3795 |
| _version_ |
1717584478202757120 |
| score |
11.687526 |