Sinu Virus, a novel and divergent orthomyxovirus related to members of the genus Thogotovirus isolated from mosquitoes in Colombia.
The genome and structural organization of a novel insect-specific orthomyxovirus, designated Sinu virus, is described. Sinu virus (SINUV) was isolated in cultures of C6/36 cells from a pool of mosquitoes collected in northwestern Colombia. The virus has six negative-sense ssRNA segments. Genetic ana...
| Autor principal: | Contreras-Guti?rrez, Mar?a Ang?lica |
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| Outros Autores: | Nunes, Marcio Roberto Teixeira, Guzman, Hilda, Uribe, Sandra, G?mez, Juan Carlos Gallego, Vasco, Juan David Suaza, Cardoso, Jedson Ferreira, Popov, Vsevolod Leonidovich, Widen, Steven G, Wood, Thomas G, Vasilakis, Nikos, Tesh, Robert B |
| Grau: | Artigo |
| Idioma: | eng |
| Publicado em: |
Elsevier
2019
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| Acesso em linha: |
http://patua.iec.gov.br//handle/iec/3856 |
| Resumo: |
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The genome and structural organization of a novel insect-specific orthomyxovirus, designated Sinu virus, is described. Sinu virus (SINUV) was isolated in cultures of C6/36 cells from a pool of mosquitoes collected in northwestern Colombia. The virus has six negative-sense ssRNA segments. Genetic analysis of each segment demonstrated the presence of six distinct ORFs encoding the following genes: PB2 (Segment 1), PB1, (Segment 2), PA protein (Segment 3), envelope GP gene (Segment 4), the NP (Segment 5), and M-like gene (Segment 6). Phylogenetically, SINUV appears to be most closed related to viruses in the genus Thogotovirus. |