Genetic characterization of the Patois Serogroup (Genus Orthobunyavirus; Family Peribunyaviridae) and evidence that Estero Real Virus is a member of the Genus Orthonairovirus

Aguilar, Patricia V; Souza, William Marciel de; Silvas, Jesus A; Wood, Thomas; Widen, Steven; Fumagalli, Marc?lio Jorge; Nunes, Marcio Roberto Teixeira

Artigo

Genetic characterization of the Patois Serogroup (Genus Orthobunyavirus; Family Peribunyaviridae) and evidence that Estero Real Virus is a member of the Genus Orthonairovirus

Estero Real virus (ERV) was isolated in 1980 from Ornithodoros tadaridae ticks collected in El Estero Real, Sancti Spiritus, Cuba. Antigenic characterization of the isolate based on serological methods found a relationship with Abras and Zegla viruses and, consequently, the virus was classified taxo...

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Autor principal:	Aguilar, Patricia V
Outros Autores:	Souza, William Marciel de, Silvas, Jesus A, Wood, Thomas, Widen, Steven, Fumagalli, Marc?lio Jorge, Nunes, Marcio Roberto Teixeira
Grau:	Artigo
Idioma:	eng
Publicado em:	American Society of Tropical Medicine and Hygiene 2019
Assuntos:	Arbovirus / classifica??o Genoma / gen?tica V?rus Estero Real Ornithodoros / gen?tica Filogenia / m?todos Sancti Sp?ritus (CU)
Acesso em linha:	http://patua.iec.gov.br//handle/iec/3860

id	ir-iec-3860
recordtype	dspace
spelling	ir-iec-38602019-08-28T13:06:36Z Genetic characterization of the Patois Serogroup (Genus Orthobunyavirus; Family Peribunyaviridae) and evidence that Estero Real Virus is a member of the Genus Orthonairovirus Aguilar, Patricia V Souza, William Marciel de Silvas, Jesus A Wood, Thomas Widen, Steven Fumagalli, Marc?lio Jorge Nunes, Marcio Roberto Teixeira Arbovirus / classifica??o Genoma / gen?tica V?rus Estero Real Ornithodoros / gen?tica Filogenia / m?todos Sancti Sp?ritus (CU) Estero Real virus (ERV) was isolated in 1980 from Ornithodoros tadaridae ticks collected in El Estero Real, Sancti Spiritus, Cuba. Antigenic characterization of the isolate based on serological methods found a relationship with Abras and Zegla viruses and, consequently, the virus was classified taxonomically within the Patois serogroup. Given the fact that genetic characterization of Patois serogroup viruses has not yet been reported and that ERV is the only virus within the Patois serogroup isolated from ticks, we recently conducted nearly complete genome sequencing in an attempt to gain further insight into the genetic relationship of ERV with other Patois serogroup viruses and members of Peribunyaviridae family (Bunyavirales order). With the exception of ERV, our sequencing and phylogenetic studies revealed the close relationship of the Patois serogroup viruses to each other, forming a clear divergent clade from other members of the Orthobunyavirus genus (Peribunyaviridae family). Notably, our analysis also revealed that ERV forms a monophyletic clade that is closely related to species of the Orthonairovirus genus (Nairoviridae family) in all the genome segments. In light of these findings, we believe that the taxonomic classification of ERV should be revised. F31 AI124662/AI/NIAID NIH HHS/United States R24 AI120942/AI/NIAID NIH HHS/United States 2019-08-28T12:59:19Z 2019-08-28T12:59:19Z 2018 Artigo AGUILAR, Patricia V. et al. Genetic characterization of the Patois Serogroup (Genus Orthobunyavirus; Family Peribunyaviridae) and evidence that Estero Real Virus is a member of the Genus Orthonairovirus. The American Journal of Tropical Medicine and Hygiene, v. 99, n. 2, p. 451-457, Aug. 2018. 0002-9637 http://patua.iec.gov.br//handle/iec/3860 10.4269/ajtmh.18-0201 eng Acesso Aberto application/pdf American Society of Tropical Medicine and Hygiene
institution	Instituto Evandro Chagas (IEC)
collection	PATUA
language	eng
topic	Arbovirus / classifica??o Genoma / gen?tica V?rus Estero Real Ornithodoros / gen?tica Filogenia / m?todos Sancti Sp?ritus (CU)
spellingShingle	Arbovirus / classifica??o Genoma / gen?tica V?rus Estero Real Ornithodoros / gen?tica Filogenia / m?todos Sancti Sp?ritus (CU) Aguilar, Patricia V Genetic characterization of the Patois Serogroup (Genus Orthobunyavirus; Family Peribunyaviridae) and evidence that Estero Real Virus is a member of the Genus Orthonairovirus
topic_facet	Arbovirus / classifica??o Genoma / gen?tica V?rus Estero Real Ornithodoros / gen?tica Filogenia / m?todos Sancti Sp?ritus (CU)
description	Estero Real virus (ERV) was isolated in 1980 from Ornithodoros tadaridae ticks collected in El Estero Real, Sancti Spiritus, Cuba. Antigenic characterization of the isolate based on serological methods found a relationship with Abras and Zegla viruses and, consequently, the virus was classified taxonomically within the Patois serogroup. Given the fact that genetic characterization of Patois serogroup viruses has not yet been reported and that ERV is the only virus within the Patois serogroup isolated from ticks, we recently conducted nearly complete genome sequencing in an attempt to gain further insight into the genetic relationship of ERV with other Patois serogroup viruses and members of Peribunyaviridae family (Bunyavirales order). With the exception of ERV, our sequencing and phylogenetic studies revealed the close relationship of the Patois serogroup viruses to each other, forming a clear divergent clade from other members of the Orthobunyavirus genus (Peribunyaviridae family). Notably, our analysis also revealed that ERV forms a monophyletic clade that is closely related to species of the Orthonairovirus genus (Nairoviridae family) in all the genome segments. In light of these findings, we believe that the taxonomic classification of ERV should be revised.
format	Artigo
author	Aguilar, Patricia V
author2	Souza, William Marciel de Silvas, Jesus A Wood, Thomas Widen, Steven Fumagalli, Marc?lio Jorge Nunes, Marcio Roberto Teixeira
author2Str	Souza, William Marciel de Silvas, Jesus A Wood, Thomas Widen, Steven Fumagalli, Marc?lio Jorge Nunes, Marcio Roberto Teixeira
title	Genetic characterization of the Patois Serogroup (Genus Orthobunyavirus; Family Peribunyaviridae) and evidence that Estero Real Virus is a member of the Genus Orthonairovirus
title_short	Genetic characterization of the Patois Serogroup (Genus Orthobunyavirus; Family Peribunyaviridae) and evidence that Estero Real Virus is a member of the Genus Orthonairovirus
title_full	Genetic characterization of the Patois Serogroup (Genus Orthobunyavirus; Family Peribunyaviridae) and evidence that Estero Real Virus is a member of the Genus Orthonairovirus
title_fullStr	Genetic characterization of the Patois Serogroup (Genus Orthobunyavirus; Family Peribunyaviridae) and evidence that Estero Real Virus is a member of the Genus Orthonairovirus
title_full_unstemmed	Genetic characterization of the Patois Serogroup (Genus Orthobunyavirus; Family Peribunyaviridae) and evidence that Estero Real Virus is a member of the Genus Orthonairovirus
title_sort	genetic characterization of the patois serogroup (genus orthobunyavirus; family peribunyaviridae) and evidence that estero real virus is a member of the genus orthonairovirus
publisher	American Society of Tropical Medicine and Hygiene
publishDate	2019
url	http://patua.iec.gov.br//handle/iec/3860
_version_	1717584511603048448
score	11.755432

Genetic characterization of the Patois Serogroup (Genus Orthobunyavirus; Family Peribunyaviridae) and evidence that Estero Real Virus is a member of the Genus Orthonairovirus

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