Genetic divergence and dispersal of Yellow Fever Virus, Brazil
An analysis of 79 yellow fever virus(YFV) isolates collected from 1935 to 2001 in Brazil showed a single genotype (South America) circulating in the country, with the exception of a single strain from R?ndonia, wich represented South America genotype II. Brazilian YFV strains have diverged into two...
| Autor principal: | Vasconcelos, Pedro Fernando da Costa |
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| Outros Autores: | Bryant, Juliet E, Rosa, Am?lia Paes de Andrade Travassos da, Tesh, Robert B, Rodrigues, Sueli Guerreiro, Barrett, Alan D. T |
| Grau: | Artigo |
| Idioma: | eng |
| Publicado em: |
Centers for Disease Control and Prevention
2019
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| Acesso em linha: |
http://patua.iec.gov.br//handle/iec/3958 |
| Resumo: |
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An analysis of 79 yellow fever virus(YFV) isolates collected from 1935 to 2001 in Brazil showed a single genotype (South America) circulating in the country, with the exception of a single strain from R?ndonia, wich represented South America genotype II. Brazilian YFV strains have diverged into two clades; an older clade appears to have become extinct and another has become the dominant lineage in recent years. Pairwise nucleotide diversity between strains ranged from 0 per cent to 7.4 per cent, while amino acid divergence ranged from 0 per cent to 4.6 per cent. Phylogenetic analysis indicated traffic of virus variants through large geographic areas and suggested that migration of infected people may be an important mechanism of virus dispersal. Isolation of vaccine virus from a patient with a fatal case suggests that vaccine-related illness may have been misdiagnosed in the past. |