Short-lived immunity after 17DD Yellow Fever single dose indicates that booster vaccination may be required to guarantee protective immunity in children

Campi-Azevedo, Ana Carolina; Reis, Laise Rodrigues; Peruhype-Magalh?es, Venessa; Reis, Jordana Grazziela Coelho dos; Antonelli, Lis Ribeiro; Fonseca, Cristina Toscano; Costa-Pereira, Christiane; Souza-Fagundes, Elaine Maria; Costa-Rocha, Ismael Artur da; Mambrini, Juliana Vaz de Melo; Lemos, Jandira Aparecida Campos; Ribeiro, Jos? Geraldo Leite; Caldas, Iramaya Rodrigues; Camacho, Luiz Ant?nio Bastos; Maia, Maria de Lourdes de Sousa; Noronha, Tatiana Guimar?es de; Lima, Sheila Maria Barbosa de; Sim?es, Marisol; Freire, Marcos da Silva; Martins, Reinaldo de Menezes; Homma, Akira; Tauil, Pedro Luiz; Vasconcelos, Pedro Fernando da Costa; Romano, Alessandro Pecego Martins; Domingos, Carla Magda; Teixeira-Carvalho, Andr?a; Martins Filho, Olindo Assis

Artigo

Short-lived immunity after 17DD Yellow Fever single dose indicates that booster vaccination may be required to guarantee protective immunity in children

The Yellow Fever (YF) vaccination is recommended for people living in endemic areas and represents the most effective strategy to reduce the risk of infection. Previous studies have warned that booster regimens should be considered to guarantee the long-term persistence of 17DD-YF-specific memory co...

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Autor principal:	Campi-Azevedo, Ana Carolina
Outros Autores:	Reis, Laise Rodrigues, Peruhype-Magalh?es, Venessa, Reis, Jordana Grazziela Coelho dos, Antonelli, Lis Ribeiro, Fonseca, Cristina Toscano, Costa-Pereira, Christiane, Souza-Fagundes, Elaine Maria, Costa-Rocha, Ismael Artur da, Mambrini, Juliana Vaz de Melo, Lemos, Jandira Aparecida Campos, Ribeiro, Jos? Geraldo Leite, Caldas, Iramaya Rodrigues, Camacho, Luiz Ant?nio Bastos, Maia, Maria de Lourdes de Sousa, Noronha, Tatiana Guimar?es de, Lima, Sheila Maria Barbosa de, Sim?es, Marisol, Freire, Marcos da Silva, Martins, Reinaldo de Menezes, Homma, Akira, Tauil, Pedro Luiz, Vasconcelos, Pedro Fernando da Costa, Romano, Alessandro Pecego Martins, Domingos, Carla Magda, Teixeira-Carvalho, Andr?a, Martins Filho, Olindo Assis
Grau:	Artigo
Idioma:	eng
Publicado em:	Frontiers Media 2019
Assuntos:	Febre Amarela V?rus da Febre Amarela / patogenicidade Vacina??o Vacina 17DD Mem?ria celular Anticorpos Neutralizantes Imunidade Celular
Acesso em linha:	http://patua.iec.gov.br//handle/iec/3972

id	ir-iec-3972
recordtype	dspace
spelling	ir-iec-39722019-11-13T17:23:43Z Short-lived immunity after 17DD Yellow Fever single dose indicates that booster vaccination may be required to guarantee protective immunity in children Campi-Azevedo, Ana Carolina Reis, Laise Rodrigues Peruhype-Magalh?es, Venessa Reis, Jordana Grazziela Coelho dos Antonelli, Lis Ribeiro Fonseca, Cristina Toscano Costa-Pereira, Christiane Souza-Fagundes, Elaine Maria Costa-Rocha, Ismael Artur da Mambrini, Juliana Vaz de Melo Lemos, Jandira Aparecida Campos Ribeiro, Jos? Geraldo Leite Caldas, Iramaya Rodrigues Camacho, Luiz Ant?nio Bastos Maia, Maria de Lourdes de Sousa Noronha, Tatiana Guimar?es de Lima, Sheila Maria Barbosa de Sim?es, Marisol Freire, Marcos da Silva Martins, Reinaldo de Menezes Homma, Akira Tauil, Pedro Luiz Vasconcelos, Pedro Fernando da Costa Romano, Alessandro Pecego Martins Domingos, Carla Magda Teixeira-Carvalho, Andr?a Martins Filho, Olindo Assis Febre Amarela V?rus da Febre Amarela / patogenicidade Vacina??o Vacina 17DD Mem?ria celular Anticorpos Neutralizantes Imunidade Celular The Yellow Fever (YF) vaccination is recommended for people living in endemic areas and represents the most effective strategy to reduce the risk of infection. Previous studies have warned that booster regimens should be considered to guarantee the long-term persistence of 17DD-YF-specific memory components in adults living in areas with YF-virus circulation. Considering the lower seroconversion rates observed in children (9-12 months of age) as compared to adults, this study was designed in order to access the duration of immunity in single-dose vaccinated children in a 10-years cross-sectional time-span. The levels of neutralizing antibodies (PRNT) and the phenotypic/functional memory status of T and B-cells were measured at a baseline, 30-45 days, 1, 2, 4, 7, and 10 years following primary vaccination. The results revealed that a single dose induced 85% of seropositivity at 30-45 days and a progressive time-dependent decrease was observed as early as 2 years and declines toward critical values (below 60%) at time-spans of ?4-years. Moreover, short-lived YF-specific cellular immunity, mediated by memory T and B-cells was also observed after 4-years. Predicted probability and resultant memory analysis emphasize that correlates of protection (PRNT; effector memory CD8+ T-cells; non-classical memory B-cells) wane to critical values within ?4-years after primary vaccination. Together, these results clearly demonstrate the decline of 17DD-YF-specific memory response along time in children primarily vaccinated at 9-12 months of age and support the need of booster regimen to guarantee the long-term persistence of memory components for children living in areas with high risk of YF transmission. Funda??o de Amparo ? Pesquisa do Estado de Minas Gerais (FAPEMIG), BioManguinhos/FIOCRUZ, PROEP/IRR/FIOCRUZ, Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico-CNPq 2019-11-13T17:01:13Z 2019-11-13T17:01:13Z 2019 Artigo CAMPI-AZEVEDO, Ana Carolina et al. Short-lived immunity after 17DD Yellow Fever single dose indicates that booster vaccination may be required to guarantee protective immunity in children. Frontiers in Immunology, v. 10, p. 1-13, Sept. 2019. 1664-3224 http://patua.iec.gov.br//handle/iec/3972 10.3389/fimmu.2019.02192 eng Acesso Aberto application/pdf Frontiers Media
institution	Instituto Evandro Chagas (IEC)
collection	PATUA
language	eng
topic	Febre Amarela V?rus da Febre Amarela / patogenicidade Vacina??o Vacina 17DD Mem?ria celular Anticorpos Neutralizantes Imunidade Celular
spellingShingle	Febre Amarela V?rus da Febre Amarela / patogenicidade Vacina??o Vacina 17DD Mem?ria celular Anticorpos Neutralizantes Imunidade Celular Campi-Azevedo, Ana Carolina Short-lived immunity after 17DD Yellow Fever single dose indicates that booster vaccination may be required to guarantee protective immunity in children
topic_facet	Febre Amarela V?rus da Febre Amarela / patogenicidade Vacina??o Vacina 17DD Mem?ria celular Anticorpos Neutralizantes Imunidade Celular
description	The Yellow Fever (YF) vaccination is recommended for people living in endemic areas and represents the most effective strategy to reduce the risk of infection. Previous studies have warned that booster regimens should be considered to guarantee the long-term persistence of 17DD-YF-specific memory components in adults living in areas with YF-virus circulation. Considering the lower seroconversion rates observed in children (9-12 months of age) as compared to adults, this study was designed in order to access the duration of immunity in single-dose vaccinated children in a 10-years cross-sectional time-span. The levels of neutralizing antibodies (PRNT) and the phenotypic/functional memory status of T and B-cells were measured at a baseline, 30-45 days, 1, 2, 4, 7, and 10 years following primary vaccination. The results revealed that a single dose induced 85% of seropositivity at 30-45 days and a progressive time-dependent decrease was observed as early as 2 years and declines toward critical values (below 60%) at time-spans of ?4-years. Moreover, short-lived YF-specific cellular immunity, mediated by memory T and B-cells was also observed after 4-years. Predicted probability and resultant memory analysis emphasize that correlates of protection (PRNT; effector memory CD8+ T-cells; non-classical memory B-cells) wane to critical values within ?4-years after primary vaccination. Together, these results clearly demonstrate the decline of 17DD-YF-specific memory response along time in children primarily vaccinated at 9-12 months of age and support the need of booster regimen to guarantee the long-term persistence of memory components for children living in areas with high risk of YF transmission.
format	Artigo
author	Campi-Azevedo, Ana Carolina
author2	Reis, Laise Rodrigues Peruhype-Magalh?es, Venessa Reis, Jordana Grazziela Coelho dos Antonelli, Lis Ribeiro Fonseca, Cristina Toscano Costa-Pereira, Christiane Souza-Fagundes, Elaine Maria Costa-Rocha, Ismael Artur da Mambrini, Juliana Vaz de Melo Lemos, Jandira Aparecida Campos Ribeiro, Jos? Geraldo Leite Caldas, Iramaya Rodrigues Camacho, Luiz Ant?nio Bastos Maia, Maria de Lourdes de Sousa Noronha, Tatiana Guimar?es de Lima, Sheila Maria Barbosa de Sim?es, Marisol Freire, Marcos da Silva Martins, Reinaldo de Menezes Homma, Akira Tauil, Pedro Luiz Vasconcelos, Pedro Fernando da Costa Romano, Alessandro Pecego Martins Domingos, Carla Magda Teixeira-Carvalho, Andr?a Martins Filho, Olindo Assis
author2Str	Reis, Laise Rodrigues Peruhype-Magalh?es, Venessa Reis, Jordana Grazziela Coelho dos Antonelli, Lis Ribeiro Fonseca, Cristina Toscano Costa-Pereira, Christiane Souza-Fagundes, Elaine Maria Costa-Rocha, Ismael Artur da Mambrini, Juliana Vaz de Melo Lemos, Jandira Aparecida Campos Ribeiro, Jos? Geraldo Leite Caldas, Iramaya Rodrigues Camacho, Luiz Ant?nio Bastos Maia, Maria de Lourdes de Sousa Noronha, Tatiana Guimar?es de Lima, Sheila Maria Barbosa de Sim?es, Marisol Freire, Marcos da Silva Martins, Reinaldo de Menezes Homma, Akira Tauil, Pedro Luiz Vasconcelos, Pedro Fernando da Costa Romano, Alessandro Pecego Martins Domingos, Carla Magda Teixeira-Carvalho, Andr?a Martins Filho, Olindo Assis
title	Short-lived immunity after 17DD Yellow Fever single dose indicates that booster vaccination may be required to guarantee protective immunity in children
title_short	Short-lived immunity after 17DD Yellow Fever single dose indicates that booster vaccination may be required to guarantee protective immunity in children
title_full	Short-lived immunity after 17DD Yellow Fever single dose indicates that booster vaccination may be required to guarantee protective immunity in children
title_fullStr	Short-lived immunity after 17DD Yellow Fever single dose indicates that booster vaccination may be required to guarantee protective immunity in children
title_full_unstemmed	Short-lived immunity after 17DD Yellow Fever single dose indicates that booster vaccination may be required to guarantee protective immunity in children
title_sort	short-lived immunity after 17dd yellow fever single dose indicates that booster vaccination may be required to guarantee protective immunity in children
publisher	Frontiers Media
publishDate	2019
url	http://patua.iec.gov.br//handle/iec/3972
_version_	1717584452846092288
score	11.755432

Short-lived immunity after 17DD Yellow Fever single dose indicates that booster vaccination may be required to guarantee protective immunity in children

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