Towards therapeutic alternatives for mercury neurotoxicity in the amazon: unraveling the pre-clinical effects of the superfruit a?a? (euterpe oleracea, mart.) as juice for human consumption

Crespo-L?pez, Maria Elena; Soares, Ericks Sousa; Macchi, Barbarella de Matos; Santos-Sacramento, Leticia; Takeda, Priscila Yuki; Lopes-Ara?jo, Amanda; Paraense, Ricardo Sousa de Oliveira; Souza-Monteiro, Jos? Rog?rio; Oliveira, Marcus Augusto de; Luz, Diandra Ara?jo; Maia, Cristiane do Socorro Ferraz; Rogez, Herv?; Lima, Marcelo de Oliveira; Pereira, Jo?o Paulo; Oliveira, Diomar Cavalcante; Burbano, Rommel Rodrigues; Lima, Rafael Rodrigues; Nascimento, Jos? Luiz Martins do; Arrifano, Gabriela de Paula

Artigo

Towards therapeutic alternatives for mercury neurotoxicity in the amazon: unraveling the pre-clinical effects of the superfruit a?a? (euterpe oleracea, mart.) as juice for human consumption

Methylmercury (MeHg) exposure is a serious problem of public health, especially in the Amazon. Exposure in riverine populations is responsible for neurobehavioral abnormalities. It was hypothesized that consumption of Amazonian fruits could protect by reducing mercury accumulation. This work analyze...

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Autor principal:	Crespo-L?pez, Maria Elena
Outros Autores:	Soares, Ericks Sousa, Macchi, Barbarella de Matos, Santos-Sacramento, Leticia, Takeda, Priscila Yuki, Lopes-Ara?jo, Amanda, Paraense, Ricardo Sousa de Oliveira, Souza-Monteiro, Jos? Rog?rio, Oliveira, Marcus Augusto de, Luz, Diandra Ara?jo, Maia, Cristiane do Socorro Ferraz, Rogez, Herv?, Lima, Marcelo de Oliveira, Pereira, Jo?o Paulo, Oliveira, Diomar Cavalcante, Burbano, Rommel Rodrigues, Lima, Rafael Rodrigues, Nascimento, Jos? Luiz Martins do, Arrifano, Gabriela de Paula
Grau:	Artigo
Idioma:	eng
Publicado em:	MDPI 2019
Assuntos:	Euterpe / metabolismo Euterpe / efeitos dos f?rmacos Ingest?o de Alimentos Sucos de Frutas e Vegetais Antioxidantes Sistema Nervoso Central / efeitos dos f?rmacos Intoxica??o do Sistema Nervoso por Merc?rio Compostos de Metilmerc?rio / toxicidade Envelhecimento / metabolismo
Acesso em linha:	http://patua.iec.gov.br//handle/iec/3976

id	ir-iec-3976
recordtype	dspace
spelling	ir-iec-39762019-11-18T17:52:07Z Towards therapeutic alternatives for mercury neurotoxicity in the amazon: unraveling the pre-clinical effects of the superfruit a?a? (euterpe oleracea, mart.) as juice for human consumption Crespo-L?pez, Maria Elena Soares, Ericks Sousa Macchi, Barbarella de Matos Santos-Sacramento, Leticia Takeda, Priscila Yuki Lopes-Ara?jo, Amanda Paraense, Ricardo Sousa de Oliveira Souza-Monteiro, Jos? Rog?rio Oliveira, Marcus Augusto de Luz, Diandra Ara?jo Maia, Cristiane do Socorro Ferraz Rogez, Herv? Lima, Marcelo de Oliveira Pereira, Jo?o Paulo Oliveira, Diomar Cavalcante Burbano, Rommel Rodrigues Lima, Rafael Rodrigues Nascimento, Jos? Luiz Martins do Arrifano, Gabriela de Paula Euterpe / metabolismo Euterpe / efeitos dos f?rmacos Ingest?o de Alimentos Sucos de Frutas e Vegetais Antioxidantes Sistema Nervoso Central / efeitos dos f?rmacos Intoxica??o do Sistema Nervoso por Merc?rio Compostos de Metilmerc?rio / toxicidade Envelhecimento / metabolismo Methylmercury (MeHg) exposure is a serious problem of public health, especially in the Amazon. Exposure in riverine populations is responsible for neurobehavioral abnormalities. It was hypothesized that consumption of Amazonian fruits could protect by reducing mercury accumulation. This work analyzed the effects of commercial samples of Euterpe oleracea (EO) for human consumption (10 ?L/g) against MeHg i.p. exposure (2.5 mg/Kg), using neurobehavioral (open field, rotarod and pole tests), biochemical (lipid peroxidation and nitrite levels), aging-related (telomerase reverse transcriptase (TERT) mRNA expression) and toxicokinetic (MeHg content) parameters in mice. Both the pole and rotarod tests were the most sensitive tests accompanied by increased lipid peroxidation and nitrite levels in brains. MeHg reduced TERT mRNA about 50% demonstrating a strong pro-aging effect. The EO intake, similar to that of human populations, prevented all alterations, without changing the mercury content, but avoiding neurotoxicity and premature aging of the Central Nervous System (CNS). Contrary to the hypothesis found in the literature on the possible chelating properties of Amazonian fruits consumption, the effect of EO would be essentially pharmacodynamics, and possible mechanisms are discussed. Our data already support the regular consumption of EO as an excellent option for exposed Amazonian populations to have additional protection against MeHg intoxication Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico (CNPq, grant numbers 27724/2018-2 and 307564/2017-7), Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior (CAPES, grant numbers 88887.200500/2018-00 and 88881.172137/2018-01), and Pr?-reitoria de Pesquisa da Universidade Federal do Par? (PROPESP?UFPA, s/n) 2019-11-18T17:07:57Z 2019-11-18T17:07:57Z 2019 Artigo CRESPO-L?PEZ, Maria Elena et al. Towards therapeutic alternatives for mercury neurotoxicity in the amazon: unraveling the pre-clinical effects of the superfruit a?a? (euterpe oleracea, mart.) as juice for human consumption. Nutrients, v. 11, n. 11, p. 1-19, 2019. 2072-6643 http://patua.iec.gov.br//handle/iec/3976 10.3390/nu11112585 eng Acesso Aberto application/pdf MDPI
institution	Instituto Evandro Chagas (IEC)
collection	PATUA
language	eng
topic	Euterpe / metabolismo Euterpe / efeitos dos f?rmacos Ingest?o de Alimentos Sucos de Frutas e Vegetais Antioxidantes Sistema Nervoso Central / efeitos dos f?rmacos Intoxica??o do Sistema Nervoso por Merc?rio Compostos de Metilmerc?rio / toxicidade Envelhecimento / metabolismo
spellingShingle	Euterpe / metabolismo Euterpe / efeitos dos f?rmacos Ingest?o de Alimentos Sucos de Frutas e Vegetais Antioxidantes Sistema Nervoso Central / efeitos dos f?rmacos Intoxica??o do Sistema Nervoso por Merc?rio Compostos de Metilmerc?rio / toxicidade Envelhecimento / metabolismo Crespo-L?pez, Maria Elena Towards therapeutic alternatives for mercury neurotoxicity in the amazon: unraveling the pre-clinical effects of the superfruit a?a? (euterpe oleracea, mart.) as juice for human consumption
topic_facet	Euterpe / metabolismo Euterpe / efeitos dos f?rmacos Ingest?o de Alimentos Sucos de Frutas e Vegetais Antioxidantes Sistema Nervoso Central / efeitos dos f?rmacos Intoxica??o do Sistema Nervoso por Merc?rio Compostos de Metilmerc?rio / toxicidade Envelhecimento / metabolismo
description	Methylmercury (MeHg) exposure is a serious problem of public health, especially in the Amazon. Exposure in riverine populations is responsible for neurobehavioral abnormalities. It was hypothesized that consumption of Amazonian fruits could protect by reducing mercury accumulation. This work analyzed the effects of commercial samples of Euterpe oleracea (EO) for human consumption (10 ?L/g) against MeHg i.p. exposure (2.5 mg/Kg), using neurobehavioral (open field, rotarod and pole tests), biochemical (lipid peroxidation and nitrite levels), aging-related (telomerase reverse transcriptase (TERT) mRNA expression) and toxicokinetic (MeHg content) parameters in mice. Both the pole and rotarod tests were the most sensitive tests accompanied by increased lipid peroxidation and nitrite levels in brains. MeHg reduced TERT mRNA about 50% demonstrating a strong pro-aging effect. The EO intake, similar to that of human populations, prevented all alterations, without changing the mercury content, but avoiding neurotoxicity and premature aging of the Central Nervous System (CNS). Contrary to the hypothesis found in the literature on the possible chelating properties of Amazonian fruits consumption, the effect of EO would be essentially pharmacodynamics, and possible mechanisms are discussed. Our data already support the regular consumption of EO as an excellent option for exposed Amazonian populations to have additional protection against MeHg intoxication
format	Artigo
author	Crespo-L?pez, Maria Elena
author2	Soares, Ericks Sousa Macchi, Barbarella de Matos Santos-Sacramento, Leticia Takeda, Priscila Yuki Lopes-Ara?jo, Amanda Paraense, Ricardo Sousa de Oliveira Souza-Monteiro, Jos? Rog?rio Oliveira, Marcus Augusto de Luz, Diandra Ara?jo Maia, Cristiane do Socorro Ferraz Rogez, Herv? Lima, Marcelo de Oliveira Pereira, Jo?o Paulo Oliveira, Diomar Cavalcante Burbano, Rommel Rodrigues Lima, Rafael Rodrigues Nascimento, Jos? Luiz Martins do Arrifano, Gabriela de Paula
author2Str	Soares, Ericks Sousa Macchi, Barbarella de Matos Santos-Sacramento, Leticia Takeda, Priscila Yuki Lopes-Ara?jo, Amanda Paraense, Ricardo Sousa de Oliveira Souza-Monteiro, Jos? Rog?rio Oliveira, Marcus Augusto de Luz, Diandra Ara?jo Maia, Cristiane do Socorro Ferraz Rogez, Herv? Lima, Marcelo de Oliveira Pereira, Jo?o Paulo Oliveira, Diomar Cavalcante Burbano, Rommel Rodrigues Lima, Rafael Rodrigues Nascimento, Jos? Luiz Martins do Arrifano, Gabriela de Paula
title	Towards therapeutic alternatives for mercury neurotoxicity in the amazon: unraveling the pre-clinical effects of the superfruit a?a? (euterpe oleracea, mart.) as juice for human consumption
title_short	Towards therapeutic alternatives for mercury neurotoxicity in the amazon: unraveling the pre-clinical effects of the superfruit a?a? (euterpe oleracea, mart.) as juice for human consumption
title_full	Towards therapeutic alternatives for mercury neurotoxicity in the amazon: unraveling the pre-clinical effects of the superfruit a?a? (euterpe oleracea, mart.) as juice for human consumption
title_fullStr	Towards therapeutic alternatives for mercury neurotoxicity in the amazon: unraveling the pre-clinical effects of the superfruit a?a? (euterpe oleracea, mart.) as juice for human consumption
title_full_unstemmed	Towards therapeutic alternatives for mercury neurotoxicity in the amazon: unraveling the pre-clinical effects of the superfruit a?a? (euterpe oleracea, mart.) as juice for human consumption
title_sort	towards therapeutic alternatives for mercury neurotoxicity in the amazon: unraveling the pre-clinical effects of the superfruit a?a? (euterpe oleracea, mart.) as juice for human consumption
publisher	MDPI
publishDate	2019
url	http://patua.iec.gov.br//handle/iec/3976
_version_	1717584401848598528
score	11.755432

Towards therapeutic alternatives for mercury neurotoxicity in the amazon: unraveling the pre-clinical effects of the superfruit a?a? (euterpe oleracea, mart.) as juice for human consumption

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