IFN-? as a time-sensitive biomarker during Oropouche virus infection in early and late seroconverters

Oliveira, Euz?bio de; Azevedo, Raimunda do Socorro Silva; Coelho-dos-Reis, Jordana Grazziela; Antonelli, Lis Ribeiro do Valle; Ferreira, Milene Silveira; Campi-Azevedo, Ana Carolina; Costa-Silva, Matheus Fernandes; Martins, L?via Car?cio; Chiang, Jannifer Oliveira; Teixeira-Carvalho, Andr?a; Martins-Filho, Olindo Assis; Vasconcelos, Pedro Fernando da Costa

Artigo

IFN-? as a time-sensitive biomarker during Oropouche virus infection in early and late seroconverters

In the present study, patients with acute OROV fever were classified as early seroconverters (IgM/IgG positive at baseline) or late seroconverters (IgM/IgG negative at baseline) and the timeline kinetics of the production of chemokines and cytokines were assessed at 1-3, 4-7, 8-10 and ?11 days after...

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Autor principal:	Oliveira, Euz?bio de
Outros Autores:	Azevedo, Raimunda do Socorro Silva, Coelho-dos-Reis, Jordana Grazziela, Antonelli, Lis Ribeiro do Valle, Ferreira, Milene Silveira, Campi-Azevedo, Ana Carolina, Costa-Silva, Matheus Fernandes, Martins, L?via Car?cio, Chiang, Jannifer Oliveira, Teixeira-Carvalho, Andr?a, Martins-Filho, Olindo Assis, Vasconcelos, Pedro Fernando da Costa
Grau:	Artigo
Idioma:	eng
Publicado em:	Nature Research 2019
Assuntos:	Arbovirus / patogenicidade Febre Oropouche Virus Oropouche Quimiocinas Citocinas Interferon alfa-2 / an?lise
Acesso em linha:	http://patua.iec.gov.br//handle/iec/3992

id	ir-iec-3992
recordtype	dspace
spelling	ir-iec-39922019-12-10T19:40:31Z IFN-? as a time-sensitive biomarker during Oropouche virus infection in early and late seroconverters Oliveira, Euz?bio de Azevedo, Raimunda do Socorro Silva Coelho-dos-Reis, Jordana Grazziela Antonelli, Lis Ribeiro do Valle Ferreira, Milene Silveira Campi-Azevedo, Ana Carolina Costa-Silva, Matheus Fernandes Martins, L?via Car?cio Chiang, Jannifer Oliveira Teixeira-Carvalho, Andr?a Martins-Filho, Olindo Assis Vasconcelos, Pedro Fernando da Costa Arbovirus / patogenicidade Febre Oropouche Virus Oropouche Quimiocinas Citocinas Interferon alfa-2 / an?lise In the present study, patients with acute OROV fever were classified as early seroconverters (IgM/IgG positive at baseline) or late seroconverters (IgM/IgG negative at baseline) and the timeline kinetics of the production of chemokines and cytokines were assessed at 1-3, 4-7, 8-10 and ?11 days after patients have reported the first symptoms. Regardless immunoglobulin profile, all OROV fever patients presented higher levels of CXCL8, and IFN-? and lower levels of TNF and IL-10 at baseline as compared to healthy donors (HD). Lower levels of CCL2, CXCL10, and IFN-? and higher levels of CCL2, CXCL10, IL-6, and IL-17A were detected in early and late seroconverters, respectively, as compared to HD. While early seroconverters presented the increasing levels of CCL2 along the timeline, late seroconverters displayed decreasing levels of CCL2, CXCL10, and IL-6 following days of disease onset. Noteworthy was that IFN-? was revealed as universal biomarker of human OROV fever, while CXCL8 & IL-5 and CXCL10 & IL-17 were consistently observed in early and late seroconverters, respectively. Thus, our results suggest that the production of IFN-?, CXCL10, and IL-17 precede the seroconversion bringing novel insights on the immunological events triggered by the OROV disease. 2019-12-10T19:06:43Z 2019-12-10T19:06:43Z 2019 Artigo OLIVEIRA, Euz?bio de et al. IFN-? as a time-sensitive biomarker during Oropouche virus infection in early and late seroconverters. Scientific Reports, v. 9, n. 1, p. 17924, Nov. 2019. 2045-2322 http://patua.iec.gov.br//handle/iec/3992 10.1038/s41598-019-54223-w eng Acesso Aberto application/pdf Nature Research
institution	Instituto Evandro Chagas (IEC)
collection	PATUA
language	eng
topic	Arbovirus / patogenicidade Febre Oropouche Virus Oropouche Quimiocinas Citocinas Interferon alfa-2 / an?lise
spellingShingle	Arbovirus / patogenicidade Febre Oropouche Virus Oropouche Quimiocinas Citocinas Interferon alfa-2 / an?lise Oliveira, Euz?bio de IFN-? as a time-sensitive biomarker during Oropouche virus infection in early and late seroconverters
topic_facet	Arbovirus / patogenicidade Febre Oropouche Virus Oropouche Quimiocinas Citocinas Interferon alfa-2 / an?lise
description	In the present study, patients with acute OROV fever were classified as early seroconverters (IgM/IgG positive at baseline) or late seroconverters (IgM/IgG negative at baseline) and the timeline kinetics of the production of chemokines and cytokines were assessed at 1-3, 4-7, 8-10 and ?11 days after patients have reported the first symptoms. Regardless immunoglobulin profile, all OROV fever patients presented higher levels of CXCL8, and IFN-? and lower levels of TNF and IL-10 at baseline as compared to healthy donors (HD). Lower levels of CCL2, CXCL10, and IFN-? and higher levels of CCL2, CXCL10, IL-6, and IL-17A were detected in early and late seroconverters, respectively, as compared to HD. While early seroconverters presented the increasing levels of CCL2 along the timeline, late seroconverters displayed decreasing levels of CCL2, CXCL10, and IL-6 following days of disease onset. Noteworthy was that IFN-? was revealed as universal biomarker of human OROV fever, while CXCL8 & IL-5 and CXCL10 & IL-17 were consistently observed in early and late seroconverters, respectively. Thus, our results suggest that the production of IFN-?, CXCL10, and IL-17 precede the seroconversion bringing novel insights on the immunological events triggered by the OROV disease.
format	Artigo
author	Oliveira, Euz?bio de
author2	Azevedo, Raimunda do Socorro Silva Coelho-dos-Reis, Jordana Grazziela Antonelli, Lis Ribeiro do Valle Ferreira, Milene Silveira Campi-Azevedo, Ana Carolina Costa-Silva, Matheus Fernandes Martins, L?via Car?cio Chiang, Jannifer Oliveira Teixeira-Carvalho, Andr?a Martins-Filho, Olindo Assis Vasconcelos, Pedro Fernando da Costa
author2Str	Azevedo, Raimunda do Socorro Silva Coelho-dos-Reis, Jordana Grazziela Antonelli, Lis Ribeiro do Valle Ferreira, Milene Silveira Campi-Azevedo, Ana Carolina Costa-Silva, Matheus Fernandes Martins, L?via Car?cio Chiang, Jannifer Oliveira Teixeira-Carvalho, Andr?a Martins-Filho, Olindo Assis Vasconcelos, Pedro Fernando da Costa
title	IFN-? as a time-sensitive biomarker during Oropouche virus infection in early and late seroconverters
title_short	IFN-? as a time-sensitive biomarker during Oropouche virus infection in early and late seroconverters
title_full	IFN-? as a time-sensitive biomarker during Oropouche virus infection in early and late seroconverters
title_fullStr	IFN-? as a time-sensitive biomarker during Oropouche virus infection in early and late seroconverters
title_full_unstemmed	IFN-? as a time-sensitive biomarker during Oropouche virus infection in early and late seroconverters
title_sort	ifn-? as a time-sensitive biomarker during oropouche virus infection in early and late seroconverters
publisher	Nature Research
publishDate	2019
url	http://patua.iec.gov.br//handle/iec/3992
_version_	1717584352855982080
score	11.755432

IFN-? as a time-sensitive biomarker during Oropouche virus infection in early and late seroconverters

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