Artigo

Complete genome sequence of human T-cell lymphotropic type 1 from patients with different clinical profiles, including infective dermatitis

The HTLV-1 is the first human retrovirus and is associated with several clinical syndromes, however, the pathogenesis of these clinical manifestations is still not fully understood. Furthermore, there are few complete genomes publicly available, about 0.12 complete genomes per 10,000 infected indivi...

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Autor principal: Ara?jo, Thessika Hialla Almeida
Outros Autores: Barreto, Fernanda Khouri, Menezes, Aline D?rea Luz, Lima, Clayton Pereira Silva de, Oliveira, Rodrigo Santos de, Lemos, Poliana da Silva, Galv?o-Castro, Bernardo, Kashima, Simone, Farre, Lourdes, Bittencourt, Achilea Lisboa, Carvalho, Edgar Marcelino de, Santos, Luciane Amorim, Rego, Filipe Ferreira de Almeida, Mota-Miranda, Aline Cristina Andrade, Nunes, M?rcio Roberto Teixeira, Alc?ntara, Luiz Carlos J?nior
Grau: Artigo
Idioma: eng
Publicado em: Elsevier 2020
Assuntos:
V?rus Linfotr?pico T Tipo 1 Humano / isolamento & purifica??o
V?rus Linfotr?pico T Tipo 1 Humano / patogenicidade
Genoma Viral
Genoma / gen?tica
Nucleot?deos / gen?tica
Intera??es Hospedeiro-Pat?geno
Acesso em linha: http://patua.iec.gov.br//handle/iec/4051
id ir-iec-4051
recordtype dspace
spelling ir-iec-40512020-02-19T18:27:31Z Complete genome sequence of human T-cell lymphotropic type 1 from patients with different clinical profiles, including infective dermatitis Ara?jo, Thessika Hialla Almeida Barreto, Fernanda Khouri Menezes, Aline D?rea Luz Lima, Clayton Pereira Silva de Oliveira, Rodrigo Santos de Lemos, Poliana da Silva Galv?o-Castro, Bernardo Kashima, Simone Farre, Lourdes Bittencourt, Achilea Lisboa Carvalho, Edgar Marcelino de Santos, Luciane Amorim Rego, Filipe Ferreira de Almeida Mota-Miranda, Aline Cristina Andrade Nunes, M?rcio Roberto Teixeira Alc?ntara, Luiz Carlos J?nior V?rus Linfotr?pico T Tipo 1 Humano / isolamento & purifica??o V?rus Linfotr?pico T Tipo 1 Humano / patogenicidade Genoma Viral Genoma / gen?tica Nucleot?deos / gen?tica Intera??es Hospedeiro-Pat?geno The HTLV-1 is the first human retrovirus and is associated with several clinical syndromes, however, the pathogenesis of these clinical manifestations is still not fully understood. Furthermore, there are few complete genomes publicly available, about 0.12 complete genomes per 10,000 infected individuals and the databases have a major deficiency of sequences information. This study generated and characterized 31 HTLV-1 complete genomes sequences derived from individuals with Tropical Spastic Paraparesis/HTLV-1-Associated Myelopathy (TSP/HAM), Adult T-cell leukemia/lymphoma (ATL), infective dermatitis associated to HTLV-1 (IDH) and asymptomatic patients. These sequences are associated to clinical and epidemiological information about the patients. The sequencing data generated on Ion Torrent PGM platform were assembled and mapped against the reference HTLV-1 genome. These sequences were genotyped as Cosmopolitan subtype, Transcontinental subgroup. We identified the variants in the coding regions of the genome of the different clinical profiles, however, no statistical relation was detected. This study contributed to increase of HTLV-1 complete genomes in the world. Furthermore, to better investigate the contribution of HTLV-1 mutations for the disease outcome it is necessary to evaluate the interaction of the viral genome and characteristics of the human host. 2020-02-19T18:01:24Z 2020-02-19T18:01:24Z 2020 Artigo ARA?JO, Thessika Hialla Almeida et al. Complete genome sequence of human T-cell lymphotropic type 1 from patients with different clinical profiles, including infective dermatitis. Infection, Genetics and Evolution, v. 79, n. xx, p. xx, Apr. 2020. 1567-7257 http://patua.iec.gov.br//handle/iec/4051 10.1016/j.meegid.2019.104166 eng Acesso Embargado application/pdf Elsevier
institution Instituto Evandro Chagas (IEC)
collection PATUA
language eng
topic V?rus Linfotr?pico T Tipo 1 Humano / isolamento & purifica??o
V?rus Linfotr?pico T Tipo 1 Humano / patogenicidade
Genoma Viral
Genoma / gen?tica
Nucleot?deos / gen?tica
Intera??es Hospedeiro-Pat?geno
spellingShingle V?rus Linfotr?pico T Tipo 1 Humano / isolamento & purifica??o
V?rus Linfotr?pico T Tipo 1 Humano / patogenicidade
Genoma Viral
Genoma / gen?tica
Nucleot?deos / gen?tica
Intera??es Hospedeiro-Pat?geno
Ara?jo, Thessika Hialla Almeida
Complete genome sequence of human T-cell lymphotropic type 1 from patients with different clinical profiles, including infective dermatitis
topic_facet V?rus Linfotr?pico T Tipo 1 Humano / isolamento & purifica??o
V?rus Linfotr?pico T Tipo 1 Humano / patogenicidade
Genoma Viral
Genoma / gen?tica
Nucleot?deos / gen?tica
Intera??es Hospedeiro-Pat?geno
description The HTLV-1 is the first human retrovirus and is associated with several clinical syndromes, however, the pathogenesis of these clinical manifestations is still not fully understood. Furthermore, there are few complete genomes publicly available, about 0.12 complete genomes per 10,000 infected individuals and the databases have a major deficiency of sequences information. This study generated and characterized 31 HTLV-1 complete genomes sequences derived from individuals with Tropical Spastic Paraparesis/HTLV-1-Associated Myelopathy (TSP/HAM), Adult T-cell leukemia/lymphoma (ATL), infective dermatitis associated to HTLV-1 (IDH) and asymptomatic patients. These sequences are associated to clinical and epidemiological information about the patients. The sequencing data generated on Ion Torrent PGM platform were assembled and mapped against the reference HTLV-1 genome. These sequences were genotyped as Cosmopolitan subtype, Transcontinental subgroup. We identified the variants in the coding regions of the genome of the different clinical profiles, however, no statistical relation was detected. This study contributed to increase of HTLV-1 complete genomes in the world. Furthermore, to better investigate the contribution of HTLV-1 mutations for the disease outcome it is necessary to evaluate the interaction of the viral genome and characteristics of the human host.
format Artigo
author Ara?jo, Thessika Hialla Almeida
author2 Barreto, Fernanda Khouri
Menezes, Aline D?rea Luz
Lima, Clayton Pereira Silva de
Oliveira, Rodrigo Santos de
Lemos, Poliana da Silva
Galv?o-Castro, Bernardo
Kashima, Simone
Farre, Lourdes
Bittencourt, Achilea Lisboa
Carvalho, Edgar Marcelino de
Santos, Luciane Amorim
Rego, Filipe Ferreira de Almeida
Mota-Miranda, Aline Cristina Andrade
Nunes, M?rcio Roberto Teixeira
Alc?ntara, Luiz Carlos J?nior
author2Str Barreto, Fernanda Khouri
Menezes, Aline D?rea Luz
Lima, Clayton Pereira Silva de
Oliveira, Rodrigo Santos de
Lemos, Poliana da Silva
Galv?o-Castro, Bernardo
Kashima, Simone
Farre, Lourdes
Bittencourt, Achilea Lisboa
Carvalho, Edgar Marcelino de
Santos, Luciane Amorim
Rego, Filipe Ferreira de Almeida
Mota-Miranda, Aline Cristina Andrade
Nunes, M?rcio Roberto Teixeira
Alc?ntara, Luiz Carlos J?nior
title Complete genome sequence of human T-cell lymphotropic type 1 from patients with different clinical profiles, including infective dermatitis
title_short Complete genome sequence of human T-cell lymphotropic type 1 from patients with different clinical profiles, including infective dermatitis
title_full Complete genome sequence of human T-cell lymphotropic type 1 from patients with different clinical profiles, including infective dermatitis
title_fullStr Complete genome sequence of human T-cell lymphotropic type 1 from patients with different clinical profiles, including infective dermatitis
title_full_unstemmed Complete genome sequence of human T-cell lymphotropic type 1 from patients with different clinical profiles, including infective dermatitis
title_sort complete genome sequence of human t-cell lymphotropic type 1 from patients with different clinical profiles, including infective dermatitis
publisher Elsevier
publishDate 2020
url http://patua.iec.gov.br//handle/iec/4051
_version_ 1717584514407989248
score 11.674752

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