Artigo

Low prevalence of human pegivirus 1 (HPgV-1) in HTLV-1 carriers from Bel?m, Par?, North Region of Brazil

Introduction - Human pegivirus 1 (HPgV-1) is a single-stranded, positive-sense RNA virus belonging to the Flaviviridae family with limited cause-effect evidence of the causation of human diseases. However, studies have shown a potential beneficial impact of HPgV-1 coinfection in HIV disease progress...

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Autor principal: Lima, Ana Beatriz Figueiredo de
Outros Autores: S?, Keyla Santos Guedes de, Torres, Maria Karoliny da Silva, Soares, Luana da Silva, Resques, Hugo Reis, Azevedo, V?nia Nakauth, Feitosa, Rosimar Neris Martins, Monteiro, Jacqueline Cortinhas, Silva, Andrea Nazar? Monteiro Rangel da, Ribeiro, Andre Luis Ribeiro, Oliveira-Filho, Aldemir Branco de, Vallinoto, Antonio Carlos Rosario, Machado, Luiz Fernando Almeida
Grau: Artigo
Idioma: eng
Publicado em: Public Library of Science 2020
Assuntos:
Flaviviridae / isolamento & purifica??o
Infec??es por Flaviviridae
Coinfec??o
V?rus Linfotr?pico T Tipo 1 Humano
Pegiv?rus Humano 1 (HPgV-1)
Acesso em linha: http://patua.iec.gov.br//handle/iec/4091
id ir-iec-4091
recordtype dspace
spelling ir-iec-40912020-05-20T00:53:34Z Low prevalence of human pegivirus 1 (HPgV-1) in HTLV-1 carriers from Bel?m, Par?, North Region of Brazil Lima, Ana Beatriz Figueiredo de S?, Keyla Santos Guedes de Torres, Maria Karoliny da Silva Soares, Luana da Silva Resques, Hugo Reis Azevedo, V?nia Nakauth Feitosa, Rosimar Neris Martins Monteiro, Jacqueline Cortinhas Silva, Andrea Nazar? Monteiro Rangel da Ribeiro, Andre Luis Ribeiro Oliveira-Filho, Aldemir Branco de Vallinoto, Antonio Carlos Rosario Machado, Luiz Fernando Almeida Flaviviridae / isolamento & purifica??o Infec??es por Flaviviridae Coinfec??o V?rus Linfotr?pico T Tipo 1 Humano Pegiv?rus Humano 1 (HPgV-1) Introduction - Human pegivirus 1 (HPgV-1) is a single-stranded, positive-sense RNA virus belonging to the Flaviviridae family with limited cause-effect evidence of the causation of human diseases. However, studies have shown a potential beneficial impact of HPgV-1 coinfection in HIV disease progression. Human T lymphotropic virus-1 (HTLV-1) is a retrovirus known for causing diseases, especially in muscle and white blood cells, in approximately 5% of patients. Thus, this study aimed to investigate the potential effects of an HPgV-1 infection in patients carrying HTLV-1 in the state of Par? in the North Region of Brazil. Methods - A group of HTLV-1 carriers was compared to healthy controls. Blood samples were collected, data from medical regards were collected, and a questionnaire was administered. HPgV-1 and HTLV-1 positivity was determined by quantitative polymerase chain reaction (qRT-PCR). The data were analyzed to correlate the effects of HPgV-1 coinfection in HTLV-1 carriers. Results - A total of 158 samples were included in the study: 74 HTLV-1-positive patients (46,8%) and 84 healthy controls (53,2%). The overall HPgV-1 positivity rate was 7.6% (12/158), resulting in a prevalence of 5.4% (4/74) and 9.5% (8/84) in HTLV-1 carriers and healthy controls, respectively. No significant differences were found when comparing any clinical or demographic data between groups. Conclusion - This study indicated that the prevalence of HPgV-1 infection is low in HTLV-1 carriers in Bel?m, Par?, and probably does not alter the clinical course of HTLV-1 infection, however, further studies are still needed. This study was financed in part by the Coordenac??o de Aperfeic?oamento de Pessoal de N??vel Superior - Brasil (CAPES) - Finance Code 001. 2020-05-19T20:56:46Z 2020-05-19T20:56:46Z 2020 Artigo LIMA, Ana Beatriz Figueiredo de et al. Low prevalence of human pegivirus 1 (HPgV-1) in HTLV-1 carriers from Bel?m, Par?, North Region of Brazil. PLoS ONE , v. 15, n. 5, e0232783, 2020. 1932-6203 http://patua.iec.gov.br//handle/iec/4091 10.1371/journal.pone.0232783 eng Acesso Aberto application/pdf Public Library of Science
institution Instituto Evandro Chagas (IEC)
collection PATUA
language eng
topic Flaviviridae / isolamento & purifica??o
Infec??es por Flaviviridae
Coinfec??o
V?rus Linfotr?pico T Tipo 1 Humano
Pegiv?rus Humano 1 (HPgV-1)
spellingShingle Flaviviridae / isolamento & purifica??o
Infec??es por Flaviviridae
Coinfec??o
V?rus Linfotr?pico T Tipo 1 Humano
Pegiv?rus Humano 1 (HPgV-1)
Lima, Ana Beatriz Figueiredo de
Low prevalence of human pegivirus 1 (HPgV-1) in HTLV-1 carriers from Bel?m, Par?, North Region of Brazil
topic_facet Flaviviridae / isolamento & purifica??o
Infec??es por Flaviviridae
Coinfec??o
V?rus Linfotr?pico T Tipo 1 Humano
Pegiv?rus Humano 1 (HPgV-1)
description Introduction - Human pegivirus 1 (HPgV-1) is a single-stranded, positive-sense RNA virus belonging to the Flaviviridae family with limited cause-effect evidence of the causation of human diseases. However, studies have shown a potential beneficial impact of HPgV-1 coinfection in HIV disease progression. Human T lymphotropic virus-1 (HTLV-1) is a retrovirus known for causing diseases, especially in muscle and white blood cells, in approximately 5% of patients. Thus, this study aimed to investigate the potential effects of an HPgV-1 infection in patients carrying HTLV-1 in the state of Par? in the North Region of Brazil. Methods - A group of HTLV-1 carriers was compared to healthy controls. Blood samples were collected, data from medical regards were collected, and a questionnaire was administered. HPgV-1 and HTLV-1 positivity was determined by quantitative polymerase chain reaction (qRT-PCR). The data were analyzed to correlate the effects of HPgV-1 coinfection in HTLV-1 carriers. Results - A total of 158 samples were included in the study: 74 HTLV-1-positive patients (46,8%) and 84 healthy controls (53,2%). The overall HPgV-1 positivity rate was 7.6% (12/158), resulting in a prevalence of 5.4% (4/74) and 9.5% (8/84) in HTLV-1 carriers and healthy controls, respectively. No significant differences were found when comparing any clinical or demographic data between groups. Conclusion - This study indicated that the prevalence of HPgV-1 infection is low in HTLV-1 carriers in Bel?m, Par?, and probably does not alter the clinical course of HTLV-1 infection, however, further studies are still needed.
format Artigo
author Lima, Ana Beatriz Figueiredo de
author2 S?, Keyla Santos Guedes de
Torres, Maria Karoliny da Silva
Soares, Luana da Silva
Resques, Hugo Reis
Azevedo, V?nia Nakauth
Feitosa, Rosimar Neris Martins
Monteiro, Jacqueline Cortinhas
Silva, Andrea Nazar? Monteiro Rangel da
Ribeiro, Andre Luis Ribeiro
Oliveira-Filho, Aldemir Branco de
Vallinoto, Antonio Carlos Rosario
Machado, Luiz Fernando Almeida
author2Str S?, Keyla Santos Guedes de
Torres, Maria Karoliny da Silva
Soares, Luana da Silva
Resques, Hugo Reis
Azevedo, V?nia Nakauth
Feitosa, Rosimar Neris Martins
Monteiro, Jacqueline Cortinhas
Silva, Andrea Nazar? Monteiro Rangel da
Ribeiro, Andre Luis Ribeiro
Oliveira-Filho, Aldemir Branco de
Vallinoto, Antonio Carlos Rosario
Machado, Luiz Fernando Almeida
title Low prevalence of human pegivirus 1 (HPgV-1) in HTLV-1 carriers from Bel?m, Par?, North Region of Brazil
title_short Low prevalence of human pegivirus 1 (HPgV-1) in HTLV-1 carriers from Bel?m, Par?, North Region of Brazil
title_full Low prevalence of human pegivirus 1 (HPgV-1) in HTLV-1 carriers from Bel?m, Par?, North Region of Brazil
title_fullStr Low prevalence of human pegivirus 1 (HPgV-1) in HTLV-1 carriers from Bel?m, Par?, North Region of Brazil
title_full_unstemmed Low prevalence of human pegivirus 1 (HPgV-1) in HTLV-1 carriers from Bel?m, Par?, North Region of Brazil
title_sort low prevalence of human pegivirus 1 (hpgv-1) in htlv-1 carriers from bel?m, par?, north region of brazil
publisher Public Library of Science
publishDate 2020
url http://patua.iec.gov.br//handle/iec/4091
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score 11.755432

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