New record of preclinical diagnosis of American visceral leishmaniasis in Amazonian Brazil encourages optimizing disease control

Lima, Luciana; Santos, Thiago Vasconcelos dos; Campos, Marliane Batista; Ramos, Patr?cia Karla; Gomes, Claudia; Laurenti, Marcia; Matta, Vania da; Corbett, Carlos; Silveira, Fernando Tobias

Artigo

New record of preclinical diagnosis of American visceral leishmaniasis in Amazonian Brazil encourages optimizing disease control

The clinical-immunological spectrum of human Leishmania (L.) infantum chagasi-infection in Amazonian Brazil has recently been reviewed based on the combined use of the delayed-type hypersensitivity (DTH) and indirect fluorescence antibody test (IFAT-IgG/IgM), both with homologous L. (L.) infantum ch...

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Autor principal:	Lima, Luciana
Outros Autores:	Santos, Thiago Vasconcelos dos, Campos, Marliane Batista, Ramos, Patr?cia Karla, Gomes, Claudia, Laurenti, Marcia, Matta, Vania da, Corbett, Carlos, Silveira, Fernando Tobias
Grau:	Artigo
Idioma:	eng
Publicado em:	Elsevier 2020
Assuntos:	Leishmaniose Visceral / patologia Leishmaniose Visceral / parasitologia Leishmaniose Visceral / diagn?stico Controle de Doen?as Transmiss?veis
Acesso em linha:	http://patua.iec.gov.br//handle/iec/4092

id	ir-iec-4092
recordtype	dspace
spelling	ir-iec-40922020-05-26T20:07:21Z New record of preclinical diagnosis of American visceral leishmaniasis in Amazonian Brazil encourages optimizing disease control Lima, Luciana Santos, Thiago Vasconcelos dos Campos, Marliane Batista Ramos, Patr?cia Karla Gomes, Claudia Laurenti, Marcia Matta, Vania da Corbett, Carlos Silveira, Fernando Tobias Leishmaniose Visceral / patologia Leishmaniose Visceral / parasitologia Leishmaniose Visceral / diagn?stico Controle de Doen?as Transmiss?veis The clinical-immunological spectrum of human Leishmania (L.) infantum chagasi-infection in Amazonian Brazil has recently been reviewed based on the combined use of the delayed-type hypersensitivity (DTH) and indirect fluorescence antibody test (IFAT-IgG/IgM), both with homologous L. (L.) infantum chagasi-antigens, and associated with the clinical evaluation of infected individuals. This diagnostic approach has allowed to identify the broadest clinical-immunological spectrum of human L. (L.) infantum chagasi-infection composed by five clinical-immunological profiles of infection: three asymptomatic, 1) Asymptomatic Infection (AI) [DTH+/++++, IFAT?], 2) Subclinical Resistant Infection (SRI) [DTH+/++++, IFAT+/++], and 3) Indeterminate Initial Infection (III) [DTH?, IFAT+/++], and two symptomatic ones, 4) Symptomatic Infection (SI) [=American visceral leishmaniasis - AVL] and, 5) Subclinical Oligosymptomatic Infection (SOI), both with the same immune profile [DTH?, IFAT+++/++++]. Herein, we confirm for the third time the preclinical diagnosis of AVL through IgM-antibody response in an early asymptomatic case of infection (profile III), a 17-year-old boy who evolved to AVL (=profile SI) six weeks after the initial infection diagnosis, confirming that the combined use of DTH and IFAT-(IgG/IgM) assays associated with the clinical evaluation of infected individuals is potentially useful for monitoring human L. (L.) infantum chagasi-infection in endemic areas as well as optimizing AVL control. This work was supported by Instituto Evandro Chagas (Secretaria de Vigil?ncia em Sa?de, Minist?rio da Sa?de, Brazil); N?cleo de Medicina Tropical (Universidade Federal do Par?, Brazil); Laborat?rio de Investiga??o M?dica (LIM)-50 (Hospital de Cl?nicasFaculdade de Medicina-Universidade de S?o Paulo (USP), Brazil) and, Funda??o de Amparo a Pesquisa do Estado de S?o Paulo (FAPESP: 2014/50315-0). 2020-05-26T19:14:33Z 2020-05-26T19:14:33Z 2020 Artigo LIMA, Luciana et al. New record of preclinical diagnosis of American visceral leishmaniasis in Amazonian Brazil encourages optimizing disease control. Parasite Epidemiology and Control, v. 10, e00154, p. 1-6, Aug. 2020. 2405-6731 http://patua.iec.gov.br//handle/iec/4092 10.1016/j.parepi.2020.e00154 eng Acesso Aberto application/pdf Elsevier
institution	Instituto Evandro Chagas (IEC)
collection	PATUA
language	eng
topic	Leishmaniose Visceral / patologia Leishmaniose Visceral / parasitologia Leishmaniose Visceral / diagn?stico Controle de Doen?as Transmiss?veis
spellingShingle	Leishmaniose Visceral / patologia Leishmaniose Visceral / parasitologia Leishmaniose Visceral / diagn?stico Controle de Doen?as Transmiss?veis Lima, Luciana New record of preclinical diagnosis of American visceral leishmaniasis in Amazonian Brazil encourages optimizing disease control
topic_facet	Leishmaniose Visceral / patologia Leishmaniose Visceral / parasitologia Leishmaniose Visceral / diagn?stico Controle de Doen?as Transmiss?veis
description	The clinical-immunological spectrum of human Leishmania (L.) infantum chagasi-infection in Amazonian Brazil has recently been reviewed based on the combined use of the delayed-type hypersensitivity (DTH) and indirect fluorescence antibody test (IFAT-IgG/IgM), both with homologous L. (L.) infantum chagasi-antigens, and associated with the clinical evaluation of infected individuals. This diagnostic approach has allowed to identify the broadest clinical-immunological spectrum of human L. (L.) infantum chagasi-infection composed by five clinical-immunological profiles of infection: three asymptomatic, 1) Asymptomatic Infection (AI) [DTH+/++++, IFAT?], 2) Subclinical Resistant Infection (SRI) [DTH+/++++, IFAT+/++], and 3) Indeterminate Initial Infection (III) [DTH?, IFAT+/++], and two symptomatic ones, 4) Symptomatic Infection (SI) [=American visceral leishmaniasis - AVL] and, 5) Subclinical Oligosymptomatic Infection (SOI), both with the same immune profile [DTH?, IFAT+++/++++]. Herein, we confirm for the third time the preclinical diagnosis of AVL through IgM-antibody response in an early asymptomatic case of infection (profile III), a 17-year-old boy who evolved to AVL (=profile SI) six weeks after the initial infection diagnosis, confirming that the combined use of DTH and IFAT-(IgG/IgM) assays associated with the clinical evaluation of infected individuals is potentially useful for monitoring human L. (L.) infantum chagasi-infection in endemic areas as well as optimizing AVL control.
format	Artigo
author	Lima, Luciana
author2	Santos, Thiago Vasconcelos dos Campos, Marliane Batista Ramos, Patr?cia Karla Gomes, Claudia Laurenti, Marcia Matta, Vania da Corbett, Carlos Silveira, Fernando Tobias
author2Str	Santos, Thiago Vasconcelos dos Campos, Marliane Batista Ramos, Patr?cia Karla Gomes, Claudia Laurenti, Marcia Matta, Vania da Corbett, Carlos Silveira, Fernando Tobias
title	New record of preclinical diagnosis of American visceral leishmaniasis in Amazonian Brazil encourages optimizing disease control
title_short	New record of preclinical diagnosis of American visceral leishmaniasis in Amazonian Brazil encourages optimizing disease control
title_full	New record of preclinical diagnosis of American visceral leishmaniasis in Amazonian Brazil encourages optimizing disease control
title_fullStr	New record of preclinical diagnosis of American visceral leishmaniasis in Amazonian Brazil encourages optimizing disease control
title_full_unstemmed	New record of preclinical diagnosis of American visceral leishmaniasis in Amazonian Brazil encourages optimizing disease control
title_sort	new record of preclinical diagnosis of american visceral leishmaniasis in amazonian brazil encourages optimizing disease control
publisher	Elsevier
publishDate	2020
url	http://patua.iec.gov.br//handle/iec/4092
_version_	1717584353764048896
score	11.755432

New record of preclinical diagnosis of American visceral leishmaniasis in Amazonian Brazil encourages optimizing disease control

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