The complexity of respiratory disease associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection: from immunopathogenesis to respiratory therapy

Falc?o, Luiz F?bio Magno; Pontes, Lucieny da Silva; Silva, Bruno Giovanni Afonso da; Franco, Karen Margarete Vieira da Silva; Costa, Luiz Adriano Araujo da; Rocha, Rodrigo Santiago Barbosa; Quaresma, Juarez Ant?nio Sim?es

Artigo

The complexity of respiratory disease associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection: from immunopathogenesis to respiratory therapy

Covid-19, a disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, may present with polymorphic symptomatology and subclinical, neurological, gastrointestinal, dermatological, renal and severe acute respiratory manifestations. The diffuse alveolar damage caused by...

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Autor principal:	Falc?o, Luiz F?bio Magno
Outros Autores:	Pontes, Lucieny da Silva, Silva, Bruno Giovanni Afonso da, Franco, Karen Margarete Vieira da Silva, Costa, Luiz Adriano Araujo da, Rocha, Rodrigo Santiago Barbosa, Quaresma, Juarez Ant?nio Sim?es
Grau:	Artigo
Idioma:	eng
Publicado em:	Wiley 2020
Assuntos:	S?ndrome Respirat?ria Aguda Grave / imunologia V?rus da SARS / isolamento & purifica??o Coronavirus / patogenicidade Infec??es por Coronavirus Sistema Nervoso Les?o Pulmonar / patologia Manuseio das Vias A?reas
Acesso em linha:	http://patua.iec.gov.br//handle/iec/4179

id	ir-iec-4179
recordtype	dspace
spelling	ir-iec-41792021-03-22T19:09:54Z The complexity of respiratory disease associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection: from immunopathogenesis to respiratory therapy Falc?o, Luiz F?bio Magno Pontes, Lucieny da Silva Silva, Bruno Giovanni Afonso da Franco, Karen Margarete Vieira da Silva Costa, Luiz Adriano Araujo da Rocha, Rodrigo Santiago Barbosa Quaresma, Juarez Ant?nio Sim?es S?ndrome Respirat?ria Aguda Grave / imunologia V?rus da SARS / isolamento & purifica??o Coronavirus / patogenicidade Infec??es por Coronavirus Sistema Nervoso Les?o Pulmonar / patologia Manuseio das Vias A?reas Covid-19, a disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, may present with polymorphic symptomatology and subclinical, neurological, gastrointestinal, dermatological, renal and severe acute respiratory manifestations. The diffuse alveolar damage caused by the disease presents with fibrin deposition, oedema, lymphocytic inflammatory infiltrate, destruction of epithelial cells, hyaline membrane formation and occasional angiogenesis formation of microthrombi. A common radiological finding is bilateral ground glass opacity, present even in mild cases. Severe cases occur mainly among the elderly and individuals with underlying comorbidities. Here, we provide an overview of the pathophysiology of the disease associated with SARS-CoV-2 infection, interaction of the virus with the immune system, and subsequent dysfunctional immune response, essential for progression of Covid-19. We also discuss the role of the nervous system as a possible aggravating agent of the respiratory condition and propose a protocol for airway management based on the pathophysiological and immunological characteristics of the disease. Finally, we highlight the implications of such approaches for future therapeutic intervention. Amazon Foundation 2020-10-13T13:22:21Z 2020-10-13T13:22:21Z 2020 Artigo FAL??O, Luiz F?bio Magno et al. The complexity of respiratory disease associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection: from immunopathogenesis to respiratory therapy. Reviews in Medical Virology, v. 31, n. 2, e2167, Mar. 2021. 1052-9276 http://patua.iec.gov.br//handle/iec/4179 10.1002/rmv.2167 eng Acesso Embargado application/pdf Wiley
institution	Instituto Evandro Chagas (IEC)
collection	PATUA
language	eng
topic	S?ndrome Respirat?ria Aguda Grave / imunologia V?rus da SARS / isolamento & purifica??o Coronavirus / patogenicidade Infec??es por Coronavirus Sistema Nervoso Les?o Pulmonar / patologia Manuseio das Vias A?reas
spellingShingle	S?ndrome Respirat?ria Aguda Grave / imunologia V?rus da SARS / isolamento & purifica??o Coronavirus / patogenicidade Infec??es por Coronavirus Sistema Nervoso Les?o Pulmonar / patologia Manuseio das Vias A?reas Falc?o, Luiz F?bio Magno The complexity of respiratory disease associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection: from immunopathogenesis to respiratory therapy
topic_facet	S?ndrome Respirat?ria Aguda Grave / imunologia V?rus da SARS / isolamento & purifica??o Coronavirus / patogenicidade Infec??es por Coronavirus Sistema Nervoso Les?o Pulmonar / patologia Manuseio das Vias A?reas
description	Covid-19, a disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, may present with polymorphic symptomatology and subclinical, neurological, gastrointestinal, dermatological, renal and severe acute respiratory manifestations. The diffuse alveolar damage caused by the disease presents with fibrin deposition, oedema, lymphocytic inflammatory infiltrate, destruction of epithelial cells, hyaline membrane formation and occasional angiogenesis formation of microthrombi. A common radiological finding is bilateral ground glass opacity, present even in mild cases. Severe cases occur mainly among the elderly and individuals with underlying comorbidities. Here, we provide an overview of the pathophysiology of the disease associated with SARS-CoV-2 infection, interaction of the virus with the immune system, and subsequent dysfunctional immune response, essential for progression of Covid-19. We also discuss the role of the nervous system as a possible aggravating agent of the respiratory condition and propose a protocol for airway management based on the pathophysiological and immunological characteristics of the disease. Finally, we highlight the implications of such approaches for future therapeutic intervention.
format	Artigo
author	Falc?o, Luiz F?bio Magno
author2	Pontes, Lucieny da Silva Silva, Bruno Giovanni Afonso da Franco, Karen Margarete Vieira da Silva Costa, Luiz Adriano Araujo da Rocha, Rodrigo Santiago Barbosa Quaresma, Juarez Ant?nio Sim?es
author2Str	Pontes, Lucieny da Silva Silva, Bruno Giovanni Afonso da Franco, Karen Margarete Vieira da Silva Costa, Luiz Adriano Araujo da Rocha, Rodrigo Santiago Barbosa Quaresma, Juarez Ant?nio Sim?es
title	The complexity of respiratory disease associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection: from immunopathogenesis to respiratory therapy
title_short	The complexity of respiratory disease associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection: from immunopathogenesis to respiratory therapy
title_full	The complexity of respiratory disease associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection: from immunopathogenesis to respiratory therapy
title_fullStr	The complexity of respiratory disease associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection: from immunopathogenesis to respiratory therapy
title_full_unstemmed	The complexity of respiratory disease associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection: from immunopathogenesis to respiratory therapy
title_sort	complexity of respiratory disease associated with severe acute respiratory syndrome coronavirus 2 (sars-cov-2) infection: from immunopathogenesis to respiratory therapy
publisher	Wiley
publishDate	2020
url	http://patua.iec.gov.br//handle/iec/4179
_version_	1717584538661552128
score	11.653393

The complexity of respiratory disease associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection: from immunopathogenesis to respiratory therapy

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