Molecular characterization and epidemiological aspects of non-polio enteroviruses isolated from acute flaccid paralysis in Brazil: a historical series (2005?2017)

Sousa J?nior, Ivanildo Pedro de; Oliveira, Maria de Lourdes Aguiar; Burlandy, Fernanda M; Machado, Raiana Scerni; Oliveira, Silas S; Tavares, Fernando N; Gomes Neto, Francisco; Costa, Eliane V. da; Silva, Edson E. da

Artigo

Molecular characterization and epidemiological aspects of non-polio enteroviruses isolated from acute flaccid paralysis in Brazil: a historical series (2005?2017)

Due to the advanced stage of polio eradication, the possible role of non-polio enteroviruses (NPEVs) associated to acute flaccid paralysis (AFP) cases has been highlighted. In this study, we described epidemiological aspects of NPEVs infections associated to AFP and explore the viral genetic diversi...

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Autor principal:	Sousa J?nior, Ivanildo Pedro de
Outros Autores:	Oliveira, Maria de Lourdes Aguiar, Burlandy, Fernanda M, Machado, Raiana Scerni, Oliveira, Silas S, Tavares, Fernando N, Gomes Neto, Francisco, Costa, Eliane V. da, Silva, Edson E. da
Grau:	Artigo
Idioma:	eng
Publicado em:	Taylor & Francis 2020
Assuntos:	Enterovirus Poliomielite / patologia Epidemiologia Molecular Poliomielite / virologia Vigil?ncia
Acesso em linha:	http://patua.iec.gov.br//handle/iec/4208

id	ir-iec-4208
recordtype	dspace
spelling	ir-iec-42082020-12-15T17:52:45Z Molecular characterization and epidemiological aspects of non-polio enteroviruses isolated from acute flaccid paralysis in Brazil: a historical series (2005?2017) Sousa J?nior, Ivanildo Pedro de Oliveira, Maria de Lourdes Aguiar Burlandy, Fernanda M Machado, Raiana Scerni Oliveira, Silas S Tavares, Fernando N Gomes Neto, Francisco Costa, Eliane V. da Silva, Edson E. da Enterovirus Poliomielite / patologia Epidemiologia Molecular Poliomielite / virologia Vigil?ncia Due to the advanced stage of polio eradication, the possible role of non-polio enteroviruses (NPEVs) associated to acute flaccid paralysis (AFP) cases has been highlighted. In this study, we described epidemiological aspects of NPEVs infections associated to AFP and explore the viral genetic diversity, information still scarce in Brazil. From 2005 to 2017, 6707 stool samples were collected in the scope of the Brazilian Poliomyelitis Surveillance Program. NPEVs were isolated in 359 samples (5.3%) and 341 (94.9%) were genotyped. About 46 different NPEV types were identified with the following detection pattern EV-B?>?EV-A?>?EV-C. The major EV-types were CVA2, CV4, EV-A71, CVB3, CVB5, E6, E7, E11, CVA13 and EV-C99, which corresponds to 51.6% of the total. Uncommon types, such as CVA12, EV-90 and CVA11, were also identified. Different E6 genogroups were observed, prevailing the GenIII, despite periods of co-circulation, and replacement of genogroups along time. CVA2 sequences were classified as genotype C and data suggested its dispersion in South-American countries. CVA13 viruses belonged to cluster B and Venezuelan viruses composed a new putative cluster. This study provides extensive information on enterovirus diversity associated with AFP, reinforcing the need of tailoring current surveillance strategies to timely monitor emergence/re-emergence of NPEVs. 2020-12-15T17:33:44Z 2020-12-15T17:33:44Z 2020 Artigo SOUSA JR., Ivanildo Pedro de et al. Molecular characterization and epidemiological aspects of non-polio enteroviruses isolated from acute flaccid paralysis in Brasil: a historical series (2005-2017). Emerging Microbes & Infections, v. 9, p. 2536-2546, Dec. 2020. 2222-1751 http://patua.iec.gov.br//handle/iec/4208 10.1080/22221751.2020.1850181 eng Acesso Aberto application/pdf Taylor & Francis
institution	Instituto Evandro Chagas (IEC)
collection	PATUA
language	eng
topic	Enterovirus Poliomielite / patologia Epidemiologia Molecular Poliomielite / virologia Vigil?ncia
spellingShingle	Enterovirus Poliomielite / patologia Epidemiologia Molecular Poliomielite / virologia Vigil?ncia Sousa J?nior, Ivanildo Pedro de Molecular characterization and epidemiological aspects of non-polio enteroviruses isolated from acute flaccid paralysis in Brazil: a historical series (2005?2017)
topic_facet	Enterovirus Poliomielite / patologia Epidemiologia Molecular Poliomielite / virologia Vigil?ncia
description	Due to the advanced stage of polio eradication, the possible role of non-polio enteroviruses (NPEVs) associated to acute flaccid paralysis (AFP) cases has been highlighted. In this study, we described epidemiological aspects of NPEVs infections associated to AFP and explore the viral genetic diversity, information still scarce in Brazil. From 2005 to 2017, 6707 stool samples were collected in the scope of the Brazilian Poliomyelitis Surveillance Program. NPEVs were isolated in 359 samples (5.3%) and 341 (94.9%) were genotyped. About 46 different NPEV types were identified with the following detection pattern EV-B?>?EV-A?>?EV-C. The major EV-types were CVA2, CV4, EV-A71, CVB3, CVB5, E6, E7, E11, CVA13 and EV-C99, which corresponds to 51.6% of the total. Uncommon types, such as CVA12, EV-90 and CVA11, were also identified. Different E6 genogroups were observed, prevailing the GenIII, despite periods of co-circulation, and replacement of genogroups along time. CVA2 sequences were classified as genotype C and data suggested its dispersion in South-American countries. CVA13 viruses belonged to cluster B and Venezuelan viruses composed a new putative cluster. This study provides extensive information on enterovirus diversity associated with AFP, reinforcing the need of tailoring current surveillance strategies to timely monitor emergence/re-emergence of NPEVs.
format	Artigo
author	Sousa J?nior, Ivanildo Pedro de
author2	Oliveira, Maria de Lourdes Aguiar Burlandy, Fernanda M Machado, Raiana Scerni Oliveira, Silas S Tavares, Fernando N Gomes Neto, Francisco Costa, Eliane V. da Silva, Edson E. da
author2Str	Oliveira, Maria de Lourdes Aguiar Burlandy, Fernanda M Machado, Raiana Scerni Oliveira, Silas S Tavares, Fernando N Gomes Neto, Francisco Costa, Eliane V. da Silva, Edson E. da
title	Molecular characterization and epidemiological aspects of non-polio enteroviruses isolated from acute flaccid paralysis in Brazil: a historical series (2005?2017)
title_short	Molecular characterization and epidemiological aspects of non-polio enteroviruses isolated from acute flaccid paralysis in Brazil: a historical series (2005?2017)
title_full	Molecular characterization and epidemiological aspects of non-polio enteroviruses isolated from acute flaccid paralysis in Brazil: a historical series (2005?2017)
title_fullStr	Molecular characterization and epidemiological aspects of non-polio enteroviruses isolated from acute flaccid paralysis in Brazil: a historical series (2005?2017)
title_full_unstemmed	Molecular characterization and epidemiological aspects of non-polio enteroviruses isolated from acute flaccid paralysis in Brazil: a historical series (2005?2017)
title_sort	molecular characterization and epidemiological aspects of non-polio enteroviruses isolated from acute flaccid paralysis in brazil: a historical series (2005?2017)
publisher	Taylor & Francis
publishDate	2020
url	http://patua.iec.gov.br//handle/iec/4208
_version_	1717584484051714048
score	11.653393

Molecular characterization and epidemiological aspects of non-polio enteroviruses isolated from acute flaccid paralysis in Brazil: a historical series (2005?2017)

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