Increased relative delta bandpower and delta indices revealed by continuous qEEG monitoring in a rat model of ischemia-reperfusion
The present study describes the electroencephalographic changes that occur during cerebral ischemia and reperfusion in animals submitted to transient focal cerebral ischemia by middle cerebral artery occlusion (MCAO) for 30 min. For this, male Wistar rats were divided into two groups (n = 6 anima...
| Autor principal: | Ferreira, Luan Oliveira |
|---|---|
| Outros Autores: | Mattos, Bruna Gerrits, Mello, Vanessa J?ia de, Martins Filho, Arnaldo Jorge, Costa, Edmar Tavares da, Yamada, Elizabeth Sumi, Hamoy, Mois?s, Lopes, Dielly Catrina Favacho |
| Grau: | Artigo |
| Idioma: | eng |
| Publicado em: |
Frontiers Media
2021
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| Assuntos: | |
| Acesso em linha: |
http://patua.iec.gov.br//handle/iec/4295 |
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ir-iec-4295 |
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ir-iec-42952021-04-20T11:55:19Z Increased relative delta bandpower and delta indices revealed by continuous qEEG monitoring in a rat model of ischemia-reperfusion Ferreira, Luan Oliveira Mattos, Bruna Gerrits Mello, Vanessa J?ia de Martins Filho, Arnaldo Jorge Costa, Edmar Tavares da Yamada, Elizabeth Sumi Hamoy, Mois?s Lopes, Dielly Catrina Favacho Isquemia Encef?lica / veterin?ria Acidente Vascular Cerebral Infarto da Art?ria Cerebral M?dia Reperfus?o Les?es Encef?licas Eletroencefalografia / m?todos The present study describes the electroencephalographic changes that occur during cerebral ischemia and reperfusion in animals submitted to transient focal cerebral ischemia by middle cerebral artery occlusion (MCAO) for 30 min. For this, male Wistar rats were divided into two groups (n = 6 animals/group): (1) sham (control) group, and (2) ischemic/reperfusion group. The quantitative electroencephalography (qEEG) was recorded during the ischemic and immediate reperfusion (acute) phases, and then once a day for 7 days after the MCAO (subacute phase). The acute phase was characterized by a marked increase in the relative delta wave band power (p < 0.001), with a smaller, but significant increase in the relative alpha wave bandpower in the ischemic stroke phase, in comparison with the control group (p = 0.0054). In the immediate reperfusion phase, however, there was an increase in the theta, alpha, and beta waves bandpower (p < 0.001), but no alteration in the delta waves (p = 0.9984), in comparison with the control group. We also observed high values in the delta/theta ratio (DTR), the delta/alpha ratio (DAR), and the (delta+theta)/(alpha+beta) ratio (DTABR) indices during the ischemia (p < 0.05), with a major reduction in the reperfusion phase. In the subacute phase, the activity of all the waves was lower than that of the control group (p < 0.05), although the DTR, DAR, and DTABR indices remained relatively high. In conclusion, early and accurate identification of decreased delta wave bandpower, DTR, DAR, and DTABR indices, and an increase in the activity of other waves in the immediate reperfusion phase may represent an important advance for the recognition of the effectiveness of reperfusion therapy. This work was funded in part by PROPESP-UFPA. 2021-04-20T11:30:34Z 2021-04-20T11:30:34Z 2021 Artigo FERREIRA, Luan Oliveira et al. Increased relative delta bandpower and delta indices revealed by continuous qEEG monitoring in a rat model of ischemia-reperfusion. Frontiers in Neurology, v. 12, n. 645138, Apr. 2021. 1664-2295 http://patua.iec.gov.br//handle/iec/4295 10.3389/fneur.2021.645138 eng Acesso Aberto application/pdf Frontiers Media |
| institution |
Instituto Evandro Chagas (IEC) |
| collection |
PATUA |
| language |
eng |
| topic |
Isquemia Encef?lica / veterin?ria Acidente Vascular Cerebral Infarto da Art?ria Cerebral M?dia Reperfus?o Les?es Encef?licas Eletroencefalografia / m?todos |
| spellingShingle |
Isquemia Encef?lica / veterin?ria Acidente Vascular Cerebral Infarto da Art?ria Cerebral M?dia Reperfus?o Les?es Encef?licas Eletroencefalografia / m?todos Ferreira, Luan Oliveira Increased relative delta bandpower and delta indices revealed by continuous qEEG monitoring in a rat model of ischemia-reperfusion |
| topic_facet |
Isquemia Encef?lica / veterin?ria Acidente Vascular Cerebral Infarto da Art?ria Cerebral M?dia Reperfus?o Les?es Encef?licas Eletroencefalografia / m?todos |
| description |
The present study describes the electroencephalographic changes that occur during
cerebral ischemia and reperfusion in animals submitted to transient focal cerebral
ischemia by middle cerebral artery occlusion (MCAO) for 30 min. For this, male Wistar
rats were divided into two groups (n = 6 animals/group): (1) sham (control) group, and
(2) ischemic/reperfusion group. The quantitative electroencephalography (qEEG) was
recorded during the ischemic and immediate reperfusion (acute) phases, and then once a
day for 7 days after the MCAO (subacute phase). The acute phase was characterized by
a marked increase in the relative delta wave band power (p < 0.001), with a smaller, but
significant increase in the relative alpha wave bandpower in the ischemic stroke phase,
in comparison with the control group (p = 0.0054). In the immediate reperfusion phase,
however, there was an increase in the theta, alpha, and beta waves bandpower (p <
0.001), but no alteration in the delta waves (p = 0.9984), in comparison with the control
group. We also observed high values in the delta/theta ratio (DTR), the delta/alpha ratio
(DAR), and the (delta+theta)/(alpha+beta) ratio (DTABR) indices during the ischemia (p
< 0.05), with a major reduction in the reperfusion phase. In the subacute phase, the
activity of all the waves was lower than that of the control group (p < 0.05), although
the DTR, DAR, and DTABR indices remained relatively high. In conclusion, early and
accurate identification of decreased delta wave bandpower, DTR, DAR, and DTABR
indices, and an increase in the activity of other waves in the immediate reperfusion
phase may represent an important advance for the recognition of the effectiveness of
reperfusion therapy. |
| format |
Artigo |
| author |
Ferreira, Luan Oliveira |
| author2 |
Mattos, Bruna Gerrits Mello, Vanessa J?ia de Martins Filho, Arnaldo Jorge Costa, Edmar Tavares da Yamada, Elizabeth Sumi Hamoy, Mois?s Lopes, Dielly Catrina Favacho |
| author2Str |
Mattos, Bruna Gerrits Mello, Vanessa J?ia de Martins Filho, Arnaldo Jorge Costa, Edmar Tavares da Yamada, Elizabeth Sumi Hamoy, Mois?s Lopes, Dielly Catrina Favacho |
| title |
Increased relative delta bandpower and delta indices revealed by continuous qEEG monitoring in a rat model of ischemia-reperfusion |
| title_short |
Increased relative delta bandpower and delta indices revealed by continuous qEEG monitoring in a rat model of ischemia-reperfusion |
| title_full |
Increased relative delta bandpower and delta indices revealed by continuous qEEG monitoring in a rat model of ischemia-reperfusion |
| title_fullStr |
Increased relative delta bandpower and delta indices revealed by continuous qEEG monitoring in a rat model of ischemia-reperfusion |
| title_full_unstemmed |
Increased relative delta bandpower and delta indices revealed by continuous qEEG monitoring in a rat model of ischemia-reperfusion |
| title_sort |
increased relative delta bandpower and delta indices revealed by continuous qeeg monitoring in a rat model of ischemia-reperfusion |
| publisher |
Frontiers Media |
| publishDate |
2021 |
| url |
http://patua.iec.gov.br//handle/iec/4295 |
| _version_ |
1717584430871085056 |
| score |
11.674752 |