Macrophage polarization in the skin lesion caused by neotropical species of Leishmania sp

Pacheco, Carmen M. Sandoval; Flores, Gabriela Venicia Ara?jo; Gonzalez, Kadir; Gomes, Claudia M. de Castro; Passero, Luiz F. D; Tomokane, Thaise Yumie; Sosa-Ochoa, Wilfredo; Z?niga, Concepci?n; Calzada, Jose; Salda?a, Azael; Corbett, Carlos E. P; Silveira, Fernando Tobias; Laurenti, Marcia D

Artigo

Macrophage polarization in the skin lesion caused by neotropical species of Leishmania sp

Macrophages play important roles in the innate and acquired immune responses against Leishmania parasites. Depending on the subset and activation status, macrophages may eliminate intracellular parasites; however, these host cells also can offer a safe environment for Leishmania replication. In this...

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Autor principal:	Pacheco, Carmen M. Sandoval
Outros Autores:	Flores, Gabriela Venicia Ara?jo, Gonzalez, Kadir, Gomes, Claudia M. de Castro, Passero, Luiz F. D, Tomokane, Thaise Yumie, Sosa-Ochoa, Wilfredo, Z?niga, Concepci?n, Calzada, Jose, Salda?a, Azael, Corbett, Carlos E. P, Silveira, Fernando Tobias, Laurenti, Marcia D
Grau:	Artigo
Idioma:	eng
Publicado em:	Hindawi 2021
Assuntos:	Leishmania / parasitologia Macr?fagos / imunologia Desenluvamentos Cut?neos / parasitologia Pele / les?es Colora??o e Rotulagem
Acesso em linha:	http://patua.iec.gov.br//handle/iec/4308

id	ir-iec-4308
recordtype	dspace
spelling	ir-iec-43082021-05-13T17:10:10Z Macrophage polarization in the skin lesion caused by neotropical species of Leishmania sp Pacheco, Carmen M. Sandoval Flores, Gabriela Venicia Ara?jo Gonzalez, Kadir Gomes, Claudia M. de Castro Passero, Luiz F. D Tomokane, Thaise Yumie Sosa-Ochoa, Wilfredo Z?niga, Concepci?n Calzada, Jose Salda?a, Azael Corbett, Carlos E. P Silveira, Fernando Tobias Laurenti, Marcia D Leishmania / parasitologia Macr?fagos / imunologia Desenluvamentos Cut?neos / parasitologia Pele / les?es Colora??o e Rotulagem Macrophages play important roles in the innate and acquired immune responses against Leishmania parasites. Depending on the subset and activation status, macrophages may eliminate intracellular parasites; however, these host cells also can offer a safe environment for Leishmania replication. In this sense, the fate of the parasite may be influenced by the phenotype of the infected macrophage, linked to the subtype of classically activated (M1) or alternatively activated (M2) macrophages. In the present study, M1 and M2 macrophage subsets were analyzed by double-staining immunohistochemistry in skin biopsies from patients with American cutaneous leishmaniasis (ACL) caused by L. (L.) amazonensis, L. (V.) braziliensis, L. (V.) panamensis ,and L. (L.) infantum chagasi. High number of M1 macrophages was detected in nonulcerated cutaneous leishmaniasis (NUCL) caused by L. (L.) infantum chagasi (M1 = 112 ? 12, M2 = 43 ? 12 cells/mm2). On the other side, high density of M2 macrophages was observed in the skin lesions of patients with anergic diffuse cutaneous leishmaniasis (ADCL) (M1 = 195 ? 25, M2 = 616 ? 114), followed by cases of localized cutaneous leishmaniasis (LCL) caused by L. (L.) amazonensis (M1 = 97 ? 24, M2 = 219 ? 29), L. (V.) panamensis (M1 = 71 ? 14, M2 = 164 ? 14), and L. (V.) braziliensis (M1 = 50 ? 13, M2 = 53 ? 10); however, low density of M2 macrophages was observed in NUCL. The data presented herein show the polarization of macrophages in skin lesions caused by different Leishmania species that may be related with the outcome of the disease. This study was supported by the Sao Paulo Research Foundation (FAPESP) grants #2014/50315-0, #2015/01154-7, #2017/24834-9, #2018/04698-6 and GVAF and CMSP Scholarship from CAPES (Social Demand) and Laborat?rio de Patologia de Mol?stias Infecciosas (LIM50 HC-FMUSP). MDL is a research fellow from the National Research Council-CNPq, Brazil, grant #302174/2017-6. 2021-05-13T16:06:23Z 2021-05-13T16:06:23Z 2021 Artigo PACHECO, Carmen M. Sandoval et al. Macrophage polarization in the skin lesion caused by neotropical species of Leishmania sp. Journal of Immunology Research, v. 2021, n. ID 5596876, p. 1-8, 2021. 2314-7156 http://patua.iec.gov.br//handle/iec/4308 10.1155/2021/5596876 eng Acesso Aberto application/pdf Hindawi
institution	Instituto Evandro Chagas (IEC)
collection	PATUA
language	eng
topic	Leishmania / parasitologia Macr?fagos / imunologia Desenluvamentos Cut?neos / parasitologia Pele / les?es Colora??o e Rotulagem
spellingShingle	Leishmania / parasitologia Macr?fagos / imunologia Desenluvamentos Cut?neos / parasitologia Pele / les?es Colora??o e Rotulagem Pacheco, Carmen M. Sandoval Macrophage polarization in the skin lesion caused by neotropical species of Leishmania sp
topic_facet	Leishmania / parasitologia Macr?fagos / imunologia Desenluvamentos Cut?neos / parasitologia Pele / les?es Colora??o e Rotulagem
description	Macrophages play important roles in the innate and acquired immune responses against Leishmania parasites. Depending on the subset and activation status, macrophages may eliminate intracellular parasites; however, these host cells also can offer a safe environment for Leishmania replication. In this sense, the fate of the parasite may be influenced by the phenotype of the infected macrophage, linked to the subtype of classically activated (M1) or alternatively activated (M2) macrophages. In the present study, M1 and M2 macrophage subsets were analyzed by double-staining immunohistochemistry in skin biopsies from patients with American cutaneous leishmaniasis (ACL) caused by L. (L.) amazonensis, L. (V.) braziliensis, L. (V.) panamensis ,and L. (L.) infantum chagasi. High number of M1 macrophages was detected in nonulcerated cutaneous leishmaniasis (NUCL) caused by L. (L.) infantum chagasi (M1 = 112 ? 12, M2 = 43 ? 12 cells/mm2). On the other side, high density of M2 macrophages was observed in the skin lesions of patients with anergic diffuse cutaneous leishmaniasis (ADCL) (M1 = 195 ? 25, M2 = 616 ? 114), followed by cases of localized cutaneous leishmaniasis (LCL) caused by L. (L.) amazonensis (M1 = 97 ? 24, M2 = 219 ? 29), L. (V.) panamensis (M1 = 71 ? 14, M2 = 164 ? 14), and L. (V.) braziliensis (M1 = 50 ? 13, M2 = 53 ? 10); however, low density of M2 macrophages was observed in NUCL. The data presented herein show the polarization of macrophages in skin lesions caused by different Leishmania species that may be related with the outcome of the disease.
format	Artigo
author	Pacheco, Carmen M. Sandoval
author2	Flores, Gabriela Venicia Ara?jo Gonzalez, Kadir Gomes, Claudia M. de Castro Passero, Luiz F. D Tomokane, Thaise Yumie Sosa-Ochoa, Wilfredo Z?niga, Concepci?n Calzada, Jose Salda?a, Azael Corbett, Carlos E. P Silveira, Fernando Tobias Laurenti, Marcia D
author2Str	Flores, Gabriela Venicia Ara?jo Gonzalez, Kadir Gomes, Claudia M. de Castro Passero, Luiz F. D Tomokane, Thaise Yumie Sosa-Ochoa, Wilfredo Z?niga, Concepci?n Calzada, Jose Salda?a, Azael Corbett, Carlos E. P Silveira, Fernando Tobias Laurenti, Marcia D
title	Macrophage polarization in the skin lesion caused by neotropical species of Leishmania sp
title_short	Macrophage polarization in the skin lesion caused by neotropical species of Leishmania sp
title_full	Macrophage polarization in the skin lesion caused by neotropical species of Leishmania sp
title_fullStr	Macrophage polarization in the skin lesion caused by neotropical species of Leishmania sp
title_full_unstemmed	Macrophage polarization in the skin lesion caused by neotropical species of Leishmania sp
title_sort	macrophage polarization in the skin lesion caused by neotropical species of leishmania sp
publisher	Hindawi
publishDate	2021
url	http://patua.iec.gov.br//handle/iec/4308
_version_	1717584406350135296
score	11.653393

Macrophage polarization in the skin lesion caused by neotropical species of Leishmania sp

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