In vivo evaluation of the potential protective effects of prolactin against damage caused by methylmercury
Non-biodegradable metals such as mercury accumulate in living organisms during life (bioaccumulation) and also within trophic webs (biomagnification) and may reach high concentrations in humans. The contamination of humans by mercury in drinking water and food may be common, in particular in river...
| Autor principal: | CUNHA, Lorena Araújo da |
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| Outros Autores: | BOFIM, L, LIMA, G, SILVA, R, SILVA, L, LIMA, P, OLIVEIRA-BAHIA, Veronica Regina Lobato de, FREITAS, J, BURBANO, Rommel Mario Rodríguez, ROCHA, Carlos Alberto Machado da |
| Grau: | Artigo |
| Idioma: | eng |
| Publicado em: |
Brasil
2022
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| Acesso em linha: |
https://doi.org/10.1590/1414-431X2022e11976 https://repositorio.ifpa.edu.br/jspui/handle/prefix/352 |
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oai:10.0.2.15:prefix-352 |
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oai:10.0.2.15:prefix-3522023-06-28T18:27:04Z In vivo evaluation of the potential protective effects of prolactin against damage caused by methylmercury CUNHA, Lorena Araújo da BOFIM, L LIMA, G SILVA, R SILVA, L LIMA, P OLIVEIRA-BAHIA, Veronica Regina Lobato de FREITAS, J BURBANO, Rommel Mario Rodríguez ROCHA, Carlos Alberto Machado da Mercury Prolactin Histological evaluation Biochemical parameter Genotoxicity CNPQ::CIENCIAS DA SAUDE Non-biodegradable metals such as mercury accumulate in living organisms during life (bioaccumulation) and also within trophic webs (biomagnification) and may reach high concentrations in humans. The contamination of humans by mercury in drinking water and food may be common, in particular in riverside communities that have a diet rich in fish. In vitro studies of human cell lines exposed to the cytotoxic and mutagenic effects of methylmercury have shown that prolactin has potential cytoprotective properties and may act as a co-mitogenic factor and inhibitor of apoptosis. The present in vivo study investigated the protective potential of prolactin against the toxic effects of methylmercury in the mammal Mus musculus. Histological and biochemical analyses, together with biomarker of genotoxicity, were used to verify the protective potential of prolactin in mice exposed to methylmercury. The reduction in kidney and liver tissue damage was not significant. However, results of biochemical and genotoxic analyses were excellent. After prolactin treatment, a significant reduction was observed in biochemical parameters and mutagenic effects of methylmercury. The study results therefore indicated that prolactin has protective effects against the toxicity of methylmercury and allowed us to suggest the continuation of research to propose prolactin in the future, as an alternative to prevent the damage caused by mercury, especially in populations that are more exposed. Pró-Reitoria de Pesquisa e Pós-Graduação UFPA Instituto Federal de Educação, Ciência e Tecnologia do Pará 2022-10-19T16:02:03Z 2022-10-19T16:02:03Z 2022-05-17 Artigo de Periódico CUNHA, L.; BOFIM, L.; LIMA, G.; SILVA, R.; SILVA, L.; LIMA, P.; OLIVEIRA-BAHIA, V; FREITAS, J.; BURBANO, R.; ROCHA, C. In vivo evaluation of the potential protective effects of prolactin against damage caused by methylmercury. Brazilian Journal of Medical and Biological Research, v. 55, n. e11976. 2022. Disponível em: https://repositorio.ifpa.edu.br/jspui/handle/prefix/352. Acesso em: . https://doi.org/10.1590/1414-431X2022e11976 1414-431X https://repositorio.ifpa.edu.br/jspui/handle/prefix/352 eng Brazilian Journal of Medical and Biological Research Acesso aberto Brasil https://www.scielo.br/j/bjmbr/a/sNB6FPw4GjqmMnJqrSL7bBK/?lang=en |
| institution |
Repositório Institucional - Instituto Federal de Educação, Ciência e Tecnologia do Pará |
| collection |
RI-IFPA |
| language |
eng |
| topic |
Mercury Prolactin Histological evaluation Biochemical parameter Genotoxicity CNPQ::CIENCIAS DA SAUDE |
| spellingShingle |
Mercury Prolactin Histological evaluation Biochemical parameter Genotoxicity CNPQ::CIENCIAS DA SAUDE CUNHA, Lorena Araújo da In vivo evaluation of the potential protective effects of prolactin against damage caused by methylmercury |
| topic_facet |
Mercury Prolactin Histological evaluation Biochemical parameter Genotoxicity CNPQ::CIENCIAS DA SAUDE |
| description |
Non-biodegradable metals such as mercury accumulate in living organisms during life (bioaccumulation) and also within trophic
webs (biomagnification) and may reach high concentrations in humans. The contamination of humans by mercury in drinking
water and food may be common, in particular in riverside communities that have a diet rich in fish. In vitro studies of human cell lines exposed to the cytotoxic and mutagenic effects of methylmercury have shown that prolactin has potential cytoprotective properties and may act as a co-mitogenic factor and inhibitor of apoptosis. The present in vivo study investigated the protective potential of prolactin against the toxic effects of methylmercury in the mammal Mus musculus. Histological and biochemical analyses, together with biomarker of genotoxicity, were used to verify the protective potential of prolactin in mice exposed to methylmercury. The reduction in kidney and liver tissue damage was not significant. However, results of biochemical and
genotoxic analyses were excellent. After prolactin treatment, a significant reduction was observed in biochemical parameters
and mutagenic effects of methylmercury. The study results therefore indicated that prolactin has protective effects against the
toxicity of methylmercury and allowed us to suggest the continuation of research to propose prolactin in the future, as an
alternative to prevent the damage caused by mercury, especially in populations that are more exposed. |
| format |
Artigo |
| author |
CUNHA, Lorena Araújo da |
| author2 |
BOFIM, L LIMA, G SILVA, R SILVA, L LIMA, P OLIVEIRA-BAHIA, Veronica Regina Lobato de FREITAS, J BURBANO, Rommel Mario Rodríguez ROCHA, Carlos Alberto Machado da |
| author2Str |
BOFIM, L LIMA, G SILVA, R SILVA, L LIMA, P OLIVEIRA-BAHIA, Veronica Regina Lobato de FREITAS, J BURBANO, Rommel Mario Rodríguez ROCHA, Carlos Alberto Machado da |
| title |
In vivo evaluation of the potential protective effects of prolactin against damage caused by methylmercury |
| title_short |
In vivo evaluation of the potential protective effects of prolactin against damage caused by methylmercury |
| title_full |
In vivo evaluation of the potential protective effects of prolactin against damage caused by methylmercury |
| title_fullStr |
In vivo evaluation of the potential protective effects of prolactin against damage caused by methylmercury |
| title_full_unstemmed |
In vivo evaluation of the potential protective effects of prolactin against damage caused by methylmercury |
| title_sort |
in vivo evaluation of the potential protective effects of prolactin against damage caused by methylmercury |
| publisher |
Brasil |
| publishDate |
2022 |
| url |
https://doi.org/10.1590/1414-431X2022e11976 https://repositorio.ifpa.edu.br/jspui/handle/prefix/352 |
| _version_ |
1799147364804460544 |
| score |
11.755432 |