Comparative analysis of proliferative and genetic alterations in a primary chordoid meningioma and its recurrence using locus-specific probes and AgNOR
Meningiomas are generally slow-growing benign tumours; however, recurrent cases are associated with a poor prognosis. As these tumours are commonly grouped according to their grade of malignancy, it is difficult to define tumourspecific alterations involved in their genesis and evolution. Geneti...
| Autor principal: | CORDEIRO, Ana Patricia Barros |
|---|---|
| Outros Autores: | SILVA, Fábio Pacheco Estumano da, PIECZARKA, Júlio César, NAGAMACHI, Cleusa Yoshiko, ANSELMO, Nilson Praia, BRITO, José Reginaldo Nascimento, VASCONCELOS, Douglas S., LIEHR, Thomas, WEISE, Anja, OLIVEIRA, Edivaldo Herculano Correa de |
| Grau: | Artigo |
| Idioma: | eng |
| Publicado em: |
Spandidos Publications
2023
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| Assuntos: | |
| Acesso em linha: |
https://doi.org/10.3892/mmr_00000120 https://repositorio.ifpa.edu.br/jspui/handle/prefix/423 |
| Resumo: |
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Meningiomas are generally slow-growing benign
tumours; however, recurrent cases are associated with a poor
prognosis. As these tumours are commonly grouped according
to their grade of malignancy, it is difficult to define tumourspecific alterations involved in their genesis and evolution.
Genetic comparative studies of primary and recurrent tumours
are important for the identification of the chromosomal,
genetic and proliferative alterations that are possibly involved
in the process of malignancy in this class of tumour. We
performed interphase fluorescence in situ hybridization using
region-specific probes comprising the genes MYCN, ERBB4,
CDH1, ABR, ERBB2 and NF2 as well as AgNOR staining in
a sample of primary and relapsed chordoid meningiomas. Significant differences were found in these samples regarding
the genes NF2, MYCN, ABR and ERBB2. Cell proliferation
levels also showed a significant difference. The results
suggest the involvement of the MYCN gene in the evolution
of meningiomas. |